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Fukui, Roman*; Saga, Ryo*; Matsuya, Yusuke; Tomita, Kazuo*; Kuwahara, Yoshikazu*; Ouchi, Kentaro*; Sato, Tomoaki*; Okumura, Kazuhiko*; Date, Hiroyuki*; Fukumoto, Manabu*; et al.
Scientific Reports (Internet), 12(1), p.1056_1 - 1056_12, 2022/01
Times Cited Count：11 Percentile：92.45(Multidisciplinary Sciences)Alive cancer cells after fractionated irradiations with 2 Gy X-rays per day for more than 30 days show clinically relevant radioresistant. Such radioresistance is experimentally interpreted to attributed to the increment of stem-like cell content. However, only an experimental approach cannot clarify the cell responses (DNA damage and cell death induction) of cancer stem cells, so the radioresistant mechanisms remain uncertain. In addition to the conventional cell experiments using radio-resistant cell lines established after fractionated irradiations, in this study we developed a mathematical model (so called integrated microdosimetric-kinetic (IMK) model) explicitly considering cancer stem-like cell content and DNA damage responses and investigated radioresistant mechanisms acquired after fractionated irradiations. The IMK model analysis suggested that the changes of stem-like cell fraction and DNA repair efficiency play important roles of radioresisitance acquired after irradiations. Considering these into the IMK model, we successfully reproduced the experimental survival of various cell lines and various irradiation conditions. This work would contribute to not only the precise understanding of the radioresistant mechanisms induced after irradiation but also predicting curative effects with high precision.
Nakashima, Yosuke*; Takeda, Hisahito*; Ichimura, Kazuya*; Hosoi, Katsuhiro*; Oki, Kensuke*; Sakamoto, Mizuki*; Hirata, Mafumi*; Ichimura, Makoto*; Ikezoe, Ryuya*; Imai, Tsuyoshi*; et al.
Journal of Nuclear Materials, 463, p.537 - 540, 2015/08
Times Cited Count：20 Percentile：84.82(Materials Science, Multidisciplinary)Nakashima, Yosuke*; Sakamoto, Mizuki*; Yoshikawa, Masayuki*; Oki, Kensuke*; Takeda, Hisahito*; Ichimura, Kazuya*; Hosoi, Katsuhiro*; Hirata, Mafumi*; Ichimura, Makoto*; Ikezoe, Ryuya*; et al.
Proceedings of 25th IAEA Fusion Energy Conference (FEC 2014) (CD-ROM), 8 Pages, 2014/10
Kanamori, Masashi; Hashimoto, Kazuichiro; Terunuma, Hiroshi; Ikeda, Takeshi; Omura, Akiko; Terakado, Naoya; Nagakura, Tomohiro; Fukumoto, Masahiro; Watanabe, Fumitaka; Yamamoto, Kazuya; et al.
JAEA-Review 2009-023, 61 Pages, 2009/09
JAEA-Review-2009-023.pdf:8.49MB
When a nuclear emergency occurs in Japan, the Japan Atomic Energy Agency (JAEA) provides technical support to the National government, local governments, police, fire station and license holder etc. They are Designated Public Organizations conforming to the Basic Law on Emergency Preparedness and the Basic Plan for Disaster Countermeasures. The Nuclear Emergency Assistance and Training Center (NEAT) of JAEA provides a comprehensive range of technical support activities to an Off-Site Center in case of a nuclear emergency. Specifically, NEAT gives technical advice and information, provides for the dispatch of specialist as required, supplies emergency equipments and materials to the Joint Council of Nuclear Disaster Countermeasures, which meets at the Off-Site Center. NEAT provide various lectures and training course concerning nuclear disaster prevention for those personnel taking an active part in emergency response organizations at normal time. And NEAT researches on nuclear disaster prevention and also cooperate with international organizations. This annual report summarized the activities of JAEA/NEAT in the fiscal year 2008.
Auguste, T.*; Faenov, A. Y.*; Fukumoto, Ichiro; Hulin, S.*; Magunov, A. I.*; Monot, P.*; D'Oliveira, P.*; Pikuz, T. A.*; Sasaki, Akira; Sharkov, B. Y.*; et al.
Journal of Quantitative Spectroscopy & Radiative Transfer, 71(2-6), p.147 - 156, 2001/10
Times Cited Count：14 Percentile：57.87(Optics)no abstracts in English
Zhidkov, A. G.; Sasaki, Akira; Fukumoto, Ichiro; Tajima, Toshiki; Auguste, T.*; D'Oliveira, P.*; Hulin, S.*; Monot, P.*; Faenov, A. Y.*; Pikuz, T. A.*; et al.
Physics of Plasmas, 8(8), p.3718 - 3723, 2001/08
Times Cited Count：44 Percentile：76.83(Physics, Fluids & Plasmas)no abstracts in English
Fukumoto, Ichiro; Omura, Etsuji*
Seimitsu Kogakkai-Shi, 67(6), p.916 - 921, 2001/06
no abstracts in English
Zhidkov, A. G.; Sasaki, Akira; Utsumi, Takayuki*; Fukumoto, Ichiro; Tajima, Toshiki; Saito, Fumikazu*; Hironaka, Yoichiro*; Nakamura, Kazutaka*; Kondo, Kenichi*; Yoshida, Masataka*
Physical Review E, 62(5), p.7232 - 7240, 2000/11
Times Cited Count：51 Percentile：85.86(Physics, Fluids & Plasmas)no abstracts in English
Nakashima, Yosuke*; Ichimura, Kazuya*; Takeda, Hisahito*; Iwamoto, Miki*; Hosoda, Yasunari*; Shimizu, Keita*; Oki, Kensuke*; Sakamoto, Mizuki*; Ono, Noriyasu*; Kado, Shinichiro*; et al.
no journal, ,
no abstracts in English
