Initialising ...
Initialising ...
Initialising ...
Initialising ...
Initialising ...
Initialising ...
Initialising ...
亀崎 文彦; 園田 信成*; 中田 靖*; 尾辻 豊*
Journal of UOEH, 32(3), p.211 - 220, 2010/09
Direct measurement by homogenous assays has recently been applied to measuring low-density lipoprotein-cholesterol (LDL-C) and has replaced the Friedewald calculation in Japan, but it remains unclear how direct measurement compares with the Friedewald calculation in evaluating hypercholesterolemia. The aim of this study was to determine the effect of the two methods on the diagnosis of hypercholesterolemia. In a total of 1,655 workers from our institution, we investigated the LDL-C levels by the direct and Friedewald methods. Direct LDL-C showed a significantly positive correlation with Friedewald LDL-C (R
=0.975, P
0.0001). On the other hand, the mean direct LDL-C was 5.9 mg/dl higher than mean Friedewald LDL-C (126.7
30.6 mg/dl vs. 120.830.5 mg/dl, P0.0001), and direct LDL-C was higher in 89.1% of the study population. The frequency of study subjects diagnosed with hypercholesterolemia, defined as LDL-C 
140 mg/dl, was significantly higher in the direct measurement than in the Friedewald calculation (31.7% vs. 25.1%, P0.0001). In conclusion, we demonstrated that the direct measurement showed a higher rate of hypercholesterolemia prevalence than the Friedewald calculation indicated. This result suggests that we have to give careful consideration to the method for measuring LDL-C in the clinical diagnosis and management decisions of hypercholesterolemia.
亀崎 文彦; 園田 信成*; 友常 祐介; 湯中 弘美; 尾辻 豊*
Journal of Atherosclerosis and Thrombosis, 17(6), p.638 - 643, 2010/07
被引用回数：22 パーセンタイル：48.15(Peripheral Vascular Disease)Seasonal variation in serum lipid levels in Japanese population remains unclear. The aim of this study was to determine whether the variation in lipid levels exists in Japanese workers. We investigated a total of 1,331 employees in our institution (1,192 men, 4410 years; 139 women, 3811 years) who underwent health checkups in both June (summer) and December (winter), 2008. Serum levels of low-density lipoprotein (LDL) and high-density lipoprotein (HDL) cholesterol, and triglyceride were significantly higher in winter than in summer (129.131.2 mg/dL versus 125.230.2 mg/dL, 
0.0001; 65.916.8 mg/dL versus 63.516.1 mg/dL, 0.0001; 110.467.5 mg/dL versus 107.570.4 mg/dL, 0.05; respectively), although the ratio of LDL to HDL cholesterol was comparable (2.110.81 in summer versus 2.120.81 in winter). Frequency of study subjects diagnosed hypercholesterolemia defined as LDL cholesterol 140 mg/dL was significantly higher in winter than in summer (34.5% versus 30.9%, 0.0001). In Japanese workers, we demonstrated that there is seasonal variation in serum lipid levels and prevalence of hypercholesterolemia. This result indicates that we have to give careful consideration to the season of blood sampling in clinical diagnosis and management decisions of hypercholesterolemia.
亀崎 文彦; 園田 信成*; 友常 祐介; 湯中 弘美; 尾辻 豊*
Hypertension Research, 33(6), p.568 - 572, 2010/06
被引用回数：48 パーセンタイル：72.67(Peripheral Vascular Disease)Accumulating evidences have demonstrated that seasonal variations exist in metabolic syndrome parameters. The aim of this study was to examine the hypothesis that there is seasonal variation in metabolic syndrome prevalence in Japanese subjects. We investigated a total of 1,202 male workers in our institution (44 10 years), who underwent health checkups in both June (summer) and December (winter), 2008. In this study, metabolic syndrome was defined according to the criteria proposed by National Cholesterol Education Program (NCEP), International Diabetes Federation (IDF), and Japanese Society of Internal Medicine (JSIM). Serum levels of high-density lipoprotein-cholesterol and fasting glucose, and blood pressure (BP) were significantly higher in winter than in summer, whereas waist circumference and serum levels of triglyceride were little changed. Prevalence of NCEP-, IDF-, and JSIM- metabolic syndrome in this study was 3.8, 15.1 and 12.4% in winter, 3.2, 10.7 and 8.4% in summer, respectively. Out of the metabolic syndrome components, elevated BP component was mainly connected with the seasonal variation of metabolic syndrome prevalence. The present study demonstrated the seasonal variation in metabolic syndrome prevalence in Japanese male workers. This result indicates that season of health checkups may affect a clinical diagnosis and management of metabolic syndrome.
亀崎 文彦; 園田 信成*; 尾辻 豊*
no journal, ,
Aim: The aim of this study was to determine whether elevated depressive symptoms are associated with metabolic syndrome and its parameters in Japanese population. Methods: Of 1,386 male workers who were measured variables of the metabolic parameters in their health checkup, 1,186 (44.59.6 years) answered the Zung self-rating depression scale (ZSDS). In this study, metabolic syndrome was defined according to the joint scientific statement proposed by 6 major organizations. Results: Of the 1,186 subjects, 42.1% had elevated depressive symptoms (ZSDS scores 40). The prevalence rate of metabolic syndrome was significantly higher in subjects with elevated depressive symptoms than in those without (13.2% vs 8.9%, p0.05). Of all metabolic parameters, serum levels of triglyceride were significantly higher in subjects with elevated depressive symptoms (124.779.1 mg/dL vs 111.558.4 mg/dL, p0.001), and consequently hypertriglyceridemia (28.9% vs 21.0%, p0.01) was the main component correlated with the between-group difference of metabolic syndrome prevalence. Moreover, depressive symptoms for metabolic syndrome were confusion (OR: 1.46; p0.05) and emptiness (OR: 1.50; p0.05). Conclusion: This study suggested that elevated depressive symptoms might increase metabolic syndrome prevalence through a higher occurrence of hypertriglyceridemia in Japanese male workers.
