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Yano, Masahiro; Kubo, Shinji; Yasuda, Satoshi
Chemical Engineering Journal, 528, p.172423_1 - 172423_9, 2026/01
Times Cited Count：0 Percentile：0.00(Engineering, Environmental)Shibazaki, Chie; Oku, Takayuki; 5 of others*
Bioengineering (Internet), 12(9), p.981_1 - 981_19, 2025/09
Times Cited Count：0 Percentile：0.00(Biotechnology & Applied Microbiology)Proteins and peptides are vital biomolecules, and deuterated amino acids are increasingly applied in areas such as drug discovery, metabolic tracing, and neutron scattering studies. In this study, we performed deuteration on all 20 proteinogenic amino acids, including their side chains, and established efficient methods for 13 amino acids. Using a Pt/C-catalyzed hydrogen-deuterium exchange reaction, the reaction parameters were optimized to achieve the selective and stable incorporation of deuterium. In addition, the resulting deuterated compounds, focusing on tryptophan, were characterized in order to assess their physicochemical properties. Because the deuteration reaction caused significant racemization of amino acids, deuterated D/L-tryptophan was isolated using a chiral separation method. Deuterated tryptophan characterization studies confirmed that the photostability was markedly enhanced by deuteration, whereas the acid stability showed no clear isotopic effect. The X-ray crystal structure analyses revealed minimal changes upon the hydrogen-to-deuterium substitution. These results provide a robust platform for the supply of deuterated amino acids, facilitating their application in drug development, structural analysis, and creation of advanced functional biomaterials.
He, X.*; Kagi, Hiroyuki*; Komatsu, Kazuki*; Iizuka, Riko*; Okajima, Hajime*; Hattori, Takanori; Sano, Asami; Machida, Shinichi*; Abe, Jun*; Goto, Hirotada*; et al.
Journal of Molecular Structure, 1310, p.138271_1 - 138271_8, 2024/08
Times Cited Count：0 Percentile：0.00(Chemistry, Physical)High-pressure responses of the O-D
F hydrogen bonds in deuterated magnesium hydroxyfluoride were investigated using neutron powder diffraction and Raman spectroscopy. The Rietveld analysis at ambient conditions revealed a chemical formula of Mg(OD)
F
and hydroxyl group/fluorine disorder (OD/F disorder) in the crystal structure, which gave rise to two hydrogen-bonding configurations. The Rietveld analysis showed the hydrogen-bonding geometries remains up to 9.8 GPa, indicating no pressure-induced strengthening of hydrogen bonds. The Raman spectra at ambient conditions showed three hydroxyl stretching bands at 2613, 2694, and 2718 cm
. The high frequencies of the O-D stretching modes indicated that the hydroxyls should be involved in weak or none hydrogen-bonding interactions. Up to 20.2 GPa, the mode initially centered at 2694 cm displayed a pressure-induced blue shift, revealing no strengthening of hydrogen bonds under compression. We discuss the existence of hydrogen bonds and the causes of the blue-shifting hydroxyls at ambient and at high pressures.
Micheau, C.; Ueda, Yuki; Akutsu, Kazuhiro*; Bourgeois, D.*; Motokawa, Ryuhei
Solvent Extraction and Ion Exchange, 41(2), p.221 - 240, 2023/02
Times Cited Count：5 Percentile：32.44(Chemistry, Multidisciplinary)Hirade, Tetsuya; Furuta, Hikaru*; Torikai, Yuji*; Fujimura, Yuki; Michishio, Koji*
JJAP Conference Proceedings (Internet), 9, p.011106_1 - 011106_7, 2023/00
Positron annihilation lifetime (PAL) measurements by use of a positron source of 
Na were performed for polycrystalline ITER-grade tungsten samples exposed to low-energy deuterium plasma. The energy of deuterium plasma was low and then it was expected that it would affect just near-surface region. However, we obtained the longer mean positron annihilation lifetime in the tungsten samples exposed to the low-energy deuterium plasma than the virgin tungsten samples. Moreover, almost same longer values were obtained even on the other (no exposed) side of the samples, although the thickness of the samples were about 2 mm. Although, there has been no report of observation of defect formation by existence of hydrogen or deuterium in tungsten, the results indicated that deuterium existence in tungsten can be one of reasons of defects formation.
Matsumoto, Takahiro*; Nomata, Ikumi*; Ohara, Takashi; Kanemitsu, Yoshihiko*
Physical Review Materials (Internet), 5(6), p.066003_1 - 066003_9, 2021/06
Times Cited Count：4 Percentile：14.36(Materials Science, Multidisciplinary)Takiya, Hiroaki; Kadowaki, Haruhiko; Matsushima, Akira; Matsuo, Hidehiko; Ishiyama, Masahiro; Aratani, Kenta; Tezuka, Masashi
JAEA-Technology 2020-001, 76 Pages, 2020/05
JAEA-Technology-2020-001.pdf:6.06MB
Advanced Thermal Reactor (ATR) FUGEN was operated for about 25 years, and now has been proceeding decommissioning after the approval of the decommissioning plan in Feb. 2008. The reactor, heavy water system and helium system are contaminated by tritium because of neutron absorption of heavy water, which is a moderator. Before dismantling these facilities, it is necessary to remove tritium from them for not only reducing the amount of tritium released to surrounding environment and the risk of internal exposure by tritium but also ensuring the workability. In first phase of decommissioning (Heavy Water and Other system Decontamination Period), tritium decontamination of the reactor, heavy water system and helium system started in 2008 and completed in 2018. This report shows the results of tritium decontamination of the reactor, heavy water system and helium system.
O in Fe
O
film on Fe formed in an NaOH solution containing oxidantsHaruna, Takumi*; Miyataki, Yuki*; Hirohata, Yohei*; Shibata, Toshio*; Taniguchi, Naoki; Tachikawa, Hirokazu*
Zairyo To Kankyo, 67(9), p.375 - 380, 2018/09
This research aimed to confirm the formation of FeO film on Fe immersed in aqueous 45 mass% NaOH solution containing some oxidants at the boiling temperature, to recognize the optimum immersion time for the formation of thick and protective film, and to reveal the absorption behavior of DO in the FeO film at room temperature. The results were obtained as follows. It was confirmed that FeO film was formed on Fe immersed in the NaOH solution for a time more than 0.6 ks, and the film thickness increased parabolically with an increase in the immersion time. DO absorption test was carried out to the films formed in the NaOH solution for immersion times of 1.2 and 3.6 ks. An amount of DO absorbed into the film increased with an increase in an absorption time up to 1000 ks, and an absorption time more than 1000 ks made an amount of DO constant. The constant amount of DO was larger for the film formed on Fe immersed in the NaOH solution for 3.6 ks than that for 1.2 ks. The transient of the amount of DO absorbed into the film was analyzed on the basis of Fick's law for diffusion, and diffusion coefficients of DO were obtained to be 5.1
10
cm
s and 9.910 cm s for the films formed for 1.2 and 3.6 ks, respectively. Therefore it was estimated that the diffusion coefficient of the FeO film was in the region from 5.110 cm s to 9.910 cm s.
Akutsu, Kazuhiro*; Adachi, Motoyasu*; Kawakita, Yukinobu
JAEA-Review 2018-002, 36 Pages, 2018/03
JAEA-Review-2018-002.pdf:4.67MB
Since J-PARC started operation for user programs with high-intensity pulsed neutron beams, many material and life science studies have been carried out at J-PARC. Since partial or complete deuteration of organic compounds for contrast variation in the scattering length densities of materials is one of the most effective techniques in the application of neutron scattering analysis, deuterated materials have led to significant progress in our understanding of the structure of novel organic materials. Aiming at accelerating development of deuteration activities in our country, an international workshop "Deuterated Materials Enhancing Neutron Science for Structure Function Applications" was held as a J-PARC Workshop at Ibaraki Quantum Beam Research Center from 19th October to 20th October in 2017. In this workshop, the chemical/biological deuteration activities and recent scientific results of deuterated materials enhancing neutron study in Japan and other countries were discussed by domestic/foreign deuteration and neutron scientists. This is a report of the workshop summarized by organizers.
Kadowaki, Haruhiko; Matsushima, Akira; Nakajima, Yoshiaki
Proceedings of 24th International Conference on Nuclear Engineering (ICONE-24) (DVD-ROM), 6 Pages, 2016/06
Advanced thermal reactor "FUGEN" is a heavy water-moderated boiling light water-cooled pressure tube-type reactor. Because tritium had been generated in the heavy water during the reactor operation, the heavy water system and helium system were contaminated by tritium. The chemical form of the tritium was water molecule in FUGEN. Air-through drying and vacuum drying were applied to the system drying, and it was demonstrated that both methods were effective for drying treatment of heavy water in system. Helium system, low-contamination and non inclusion, could finish the vacuum drying rapidly. However, Heavy water purification system needed long period for drying treatment. The result showed that it needed long period to dry up if the objects include the adsorbent of water such as alumina pellet, resin and silica gel. But it can be accelerated by replacement absorbed heavy water to light water from the result of drying treatment of the rotary type dehumidifier.
Yamanishi, Toshihiko; Iwai, Yasunori; Kawamura, Yoshinori; Nishi, Masataka
Fusion Engineering and Design, 81(1-7), p.797 - 802, 2006/02
Times Cited Count：9 Percentile：51.61(Nuclear Science & Technology)no abstracts in English
stateAkagi, Hiroshi; Fukazawa, Hiroshi; Yokoyama, Keiichi; Yokoyama, Atsushi
Journal of Chemical Physics, 123(18), p.184305_1 - 184305_7, 2005/11
Times Cited Count：22 Percentile：57.17(Chemistry, Physical)Vibrationally excited HOD in the fourth overtone state of the OD-stretching mode (5) has been photodissociated by ultraviolet photolysis at ca. 243.1 nm. Branching ratio between the OH- and OD-bond dissociation channels has been determined by detecting the H and D atoms. The OD-bond dissociation is the dominant channel, with the yield of H atom generated by the photolysis being below the detection limit.
Tanabe, Tetsuo*; Sugiyama, Kazuyoshi*; Coad, P.*; Bekris, N.*; Glugla, M.*; Miya, Naoyuki
Journal of Nuclear Materials, 345(2-3), p.89 - 95, 2005/10
Times Cited Count：18 Percentile：73.23(Materials Science, Multidisciplinary)no abstracts in English
Aihara, Jun; Sawa, Kazuhiro; Furuya, Yoshio*; Hojo, Tomohiro*; Furuno, Shigemi*; Yamamoto, Hiroyuki; Hojo, Kiichi; Ishihara, Masahiro
Journal of the American Ceramic Society, 88(8), p.2319 - 2321, 2005/08
Times Cited Count：0 Percentile：0.00(Materials Science, Ceramics)no abstracts in English
Sekiguchi, Tetsuhiro; Baba, Yuji; Shimoyama, Iwao; Nath, K. G.
Journal of Electron Spectroscopy and Related Phenomena, 144-147, p.437 - 441, 2005/06
Times Cited Count：3 Percentile：16.89(Spectroscopy)no abstracts in English
Suzuki, Takeshi; Nakano, Masahiro; Okawa, Hiroshi; Terunuma, Akihiro; Kishimoto, Katsumi; Yano, Masaaki
JAERI-Tech 2005-018, 84 Pages, 2005/03
JAERI-Tech-2005-018.pdf:27.52MB
no abstracts in English
Kaminaga, Atsushi; Nakamura, Hirofumi; Isobe, Kanetsugu; Arai, Takashi
Heisei-16-Nendo Osaka Daigaku Sogo Gijutsu Kenkyukai Hokokushu (CD-ROM), 4 Pages, 2005/03
no abstracts in English
Masaki, Kei; Sugiyama, Kazuyoshi*; Hayashi, Takao; Ochiai, Kentaro; Goto, Yoshitaka*; Shibahara, Takahiro*; Hirohata, Yuko*; Oya, Yasuhisa*; Miya, Naoyuki; Tanabe, Tetsuo*
Journal of Nuclear Materials, 337-339, p.553 - 559, 2005/03
Times Cited Count：26 Percentile：82.43(Materials Science, Multidisciplinary)no abstracts in English
Matsunaga, Takeshi; Yanase, Nobuyuki; Hanzawa, Yukiko; Tsuzuki, Katsunori; Naganawa, Hirochika
Journal of Water and Environment Technology (Internet), 3(2), p.243 - 252, 2005/00
In a tributary watershed of the Kuji River of Japan, the hydrological components of runoff associated with a rain storm event were investigated using isotope tracers of hydrogen (H) and oxygen (
O) in precipitations and stream water. The runoff was separated into either "old water" (pre-existing in the ground before the storm) and "new water"(from the storm precipitation). It was found that the discharge of several hazardous trace elements (Sb, Cu, Cr) was largely (24-54%) attributable to that of the new water in spite of its small contribution to the total water discharge. These investigations suggest that the new water may play an important role in the migration of atmospherically derived, hazardous trace elements to streams during rain storms.
Kusama, Yoshinori; Ishikawa, Masao; Takechi, Manabu; Nishitani, Takeo; Morioka, Atsuhiko; Sasao, Mamiko*; Isobe, Mitsutaka*; Krasilnikov, A.*; Kaschuck, Y.*
Proceedings of Plasma Science Symposium 2005/22nd Symposium on Plasma Processing (PSS-2005/SPP-22), p.395 - 396, 2005/00
The energetic neutral particles have been successfully measured with a natural diamond detector in the neutron and 
ray radiation circumstance of the JT-60U deuterium discharges. The diamond detector was covered with polyethylene and lead in order to reduce the neutron and ray background. The shield has shown expected shielding capability. A rapid increase in neutral particles has been observed at the onset of the Toroidal Alfven Eigenmode (TAE) excited by the negative-ion-based neutral beam injection. The energy range of increased neutral particles has agreed well with that predicted from the resonant interaction between the energetic ions and the TAE.
