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論文

Simultaneous measurement of neutron-induced fission and capture cross sections for $$^{241}$$Am at neutron energies below fission threshold

廣瀬 健太郎; 西尾 勝久; 牧井 宏之; 西中 一朗*; 太田 周也*; 永山 達郎*; 田村 信行*; 後藤 真一*; Andreyev, A.; Vermeulen, M. J.; et al.

Nuclear Instruments and Methods in Physics Research A, 856, p.133 - 138, 2017/06

 被引用回数:3 パーセンタイル:49.25(Instruments & Instrumentation)

Fission and capture reactions were simultaneously measured in the neutron-induced reactions of $$^{241}$$Am at J-PARC. Data were taken with the TOF method in $$E_n$$ = 0.1$$sim$$20 eV. The fission events were observed by detecting prompt fission neutrons using liquid organic scintillators. The capture reaction was measured by detecting $$gamma$$ rays from the compound nuclei using the same detectors, where the prompt fission neutrons and capture $$gamma$$ rays were separated by a pulse shape analysis. The cross sections were obtained by normalizing the relative yields at the first resonance to evaluations or other experimental data. The ratio of the fission to capture cross sections at each resonance is compared with those from an evaluated nuclear data library and other experimental data. Some differences were found between the present values and the library/literature values at several resonances.

論文

Application of laser-accelerated protons to the demonstration of DNA double-strand breaks in human cancer cells

余語 覚文; 佐藤 克俊; 錦野 将元; 森 道昭; 手島 昭樹*; 沼崎 穂高*; 村上 昌雄*; 出水 祐介*; 赤城 卓*; 永山 伸一*; et al.

Applied Physics Letters, 94(18), p.181502_1 - 181502_3, 2009/05

 被引用回数:86 パーセンタイル:5.89(Physics, Applied)

We report the demonstrated irradiation effect of laser-accelerated protons on human cancer cells. ${it In-vitro}$ (living) A549 cells are irradiated with quasi-monoenergetic proton bunches of 0.8-2.4 MeV with a single bunch duration of 15 ns. Irradiation with the proton dose of 20 Gy results in a distinct formation of $$gamma$$-H2AX foci as an indicator of DNA double-strand breaks generated in the cancer cells. This is a pioneering result in view of future investigations on the radiobiological effects of laser-driven ion beams. Unique high-current and short-bunch features make laser-driven proton bunches an excitation source for time-resolved determination of radical yields.

口頭

Current status of the HIBMC, providing particle beam radiation therapy for more than 2,600 patients, and the prospects of laser-driven proton radiotherapy

村上 昌雄*; 出水 祐介*; 丹羽 康江*; 永山 伸一*; 前田 拓也*; 馬場 理師*; 宮脇 大輔*; 寺嶋 千貴*; 有村 健*; 美馬 正幸*; et al.

no journal, , 

The Hyogo Ion Beam Medical Center was established in May 2001, a leading project of the "Hyogo Cancer Strategy". The accelerator is a synchrotron that can accelerate proton and carbon ion beams at a maximum of 230 and 320 MeV/u, respectively, and the maximum ranges in water are 300 and 200 mm, respectively. Three irradiation rooms installed with 45-degree, horizontal/vertical, and horizontal fixed ports can be used for carbon ion radiation therapy, and 2 gantry rooms can be additionally used for proton beams. Particle beam radiation therapy had been performed in 2,639 patients as of the end of March 2009. The diseases treated were prostate cancer, head and neck tumors, liver cancer, lung cancer, and bone soft tissue tumors, in decreasing order of frequency, and these 5 major diseases accounted for 87% of the cases. As the current problems of particle beam radiation therapy, the effect of the differential use of proton and carbon ion beams is unclear, adverse events, such as skin disorders, may occur due to the limitation of the broad beam method, and the necessity to install large-scale devices is an obstacle to its dissemination. We are aiming at the development and clinical application of a laser-driven proton radiotherapy device in cooperation with the Japan Atomic Energy Agency.

口頭

The Integrated laser-driven ion accelerator system; Concept and requirements for laser-driven ion beam radiotherapy

Bolton, P.; 阿部 光幸*; 赤城 卓*; Nuesslin, F.*; 堀 利彦; 岩下 芳久*; 河西 俊一; 近藤 公伯; 前田 拓也; Molls, M.*; et al.

no journal, , 

The rapid advancement of high power laser technology combined with laser-accelerated ion yields from intense laser-plasma interactions sustains a strong interest in the development of integrated laser-driven ion accelerator systems (ILDIAS) that can be used for laser-driven ion beam radiotherapy (L-IBRT). A prime motivation is the promise of significantly reduced size and cost that would afford much greater patient access. Bunch duration of several nanoseconds and high peak current (with a low duty factor) make laser-driven ion irradiation unique. En route to a compact laser-driven "clinical" radiotherapeutic facility it is essential to develop multipurpose "preclinical" or test beamlines that can be used for (1) testing suitable transport optics, diagnostics and control instrumentation, (2) medical and radiobiological studies at the cellular level and in tissue to validate the radiobiological effectiveness of laser-driven ion beam radiotherapy and (3) applications to nonmedical science and technology. Preclinical and clinical beamline development calls for delivering proton energies near 50 MeV and at least 80 MeV respectively with beam energy spread and dose accuracy at one to few percent levels. Control instrumentation and diagnostics capable of single bunch resolution at required repetition rates will be essential to verify and optimize ILDIAS machine performance and capability. In the context of L-IBRT we will discuss the ILDIAS concept as well as beam delivery and instrumentation requirements.

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