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Application of laser-accelerated protons to the demonstration of DNA double-strand breaks in human cancer cells

レーザー加速陽子線照射によるヒト由来がん細胞DNA2本鎖切断の実証

余語 覚文; 佐藤 克俊; 錦野 将元; 森 道昭; 手島 昭樹*; 沼崎 穂高*; 村上 昌雄*; 出水 祐介*; 赤城 卓*; 永山 伸一*; 小倉 浩一; 匂坂 明人; 織茂 聡; 西内 満美子; Pirozhkov, A. S.; 池上 将弘*; 反保 元伸; 榊 泰直; 鈴木 将之; 大東 出; 大石 祐嗣*; 杉山 博則*; 桐山 博光; 岡田 大; 金沢 修平; 近藤 修司; 下村 拓也; 中井 善基; 田上 学*; 笹尾 一; 若井 大介*; Bolton, P.; 大道 博行

Yogo, Akifumi; Sato, Katsutoshi; Nishikino, Masaharu; Mori, Michiaki; Teshima, Teruki*; Numasaki, Hodaka*; Murakami, Masao*; Demizu, Yusuke*; Akagi, Takashi*; Nagayama, Shinichi*; Ogura, Koichi; Sagisaka, Akito; Orimo, Satoshi; Nishiuchi, Mamiko; Pirozhkov, A. S.; Ikegami, Masahiro*; Tampo, Motonobu; Sakaki, Hironao; Suzuki, Masayuki; Daito, Izuru; Oishi, Yuji*; Sugiyama, Hironori*; Kiriyama, Hiromitsu; Okada, Hajime; Kanazawa, Shuhei; Kondo, Shuji; Shimomura, Takuya; Nakai, Yoshiki; Tanoue, Manabu*; Sasao, Hajime; Wakai, Daisuke*; Bolton, P.; Daido, Hiroyuki

We report the demonstrated irradiation effect of laser-accelerated protons on human cancer cells. ${it In-vitro}$ (living) A549 cells are irradiated with quasi-monoenergetic proton bunches of 0.8-2.4 MeV with a single bunch duration of 15 ns. Irradiation with the proton dose of 20 Gy results in a distinct formation of $$gamma$$-H2AX foci as an indicator of DNA double-strand breaks generated in the cancer cells. This is a pioneering result in view of future investigations on the radiobiological effects of laser-driven ion beams. Unique high-current and short-bunch features make laser-driven proton bunches an excitation source for time-resolved determination of radical yields.

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パーセンタイル:6.06

分野:Physics, Applied

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