Generality assessment of a model considering heterogeneous cancer cells for predicting tumor control probability for stereotactic body radiotherapy against non-small cell lung cancer

Saga, Ryo*; Matsuya, Yusuke; Obara, Hideki*; Komai, Fumio*; Yoshino, Hironori*; Aoki, Masahiko*; Hosokawa, Yoichiro*

Advances in Radiation Oncology (Internet), 9 Pages, 2024/00

https://doi.org/10.1016/j.adro.2023.101437

The curative effects after radiotherapy are evaluated by the index of tumor control probability (TCP), and the treatment regimen has been determined empirically based on clinical experiences. In recent years, in order to determine TCP for any treatment regimens based on cell experiments, it is necessary to consider the existence of radioresistant cancer stem cells, which are included in tumors at from a few to several tens of percent. Our previous study has proposed an integrated microdosimetric-kinetic (IMK) model that explicitly considers cancer stem cells, and successfully reproduced cancer cell death obtained from cell experiments and clinical TCP. However, the verification so far has been limited to comparison with the clinical data of Hirosaki University Hospital, and comparative verification with clinical data of other facilities has not been performed. In this study, we focused on the stereotactic radiotherapy against non-small cell lung cancer that prescribes a large dose at once, and compared the public data collected by meta-analysis with the IMK model. As a result, it was found that the IMK model considering cancer stem cells well reproduced the clinical TCP regardless of the observed facility type. This work would contribute to the development of technology for predicting curative effects of radiotherapy with high precision.

Microphase separation of cationic homopolymers bearing alkyl ammonium salts into sub-4 nm lamellar materials with water intercalation channels

Sujita, Ryota*; Imai, Sahori*; Ouchi, Makoto*; Aoki, Hiroyuki; Terashima, Takaya*

Macromolecules, 56(23), p.9738 - 9749, 2023/12

https://doi.org/10.1021/acs.macromol.3c01722

Longitudinal spin fluctuations driving field-reinforced superconductivity in UTe

Tokunaga, Yo; Sakai, Hironori; Kambe, Shinsaku; Opletal, P.; Tokiwa, Yoshifumi; Haga, Yoshinori; Kitagawa, Shunsaku*; Ishida, Kenji*; Aoki, Dai*; Knebel, G.*; et al.

Physical Review Letters, 131(22), p.226503_1 - 226503_7, 2023/12

https://doi.org/10.1103/PhysRevLett.131.226503

Magnetic and fermi surface properties of semimetals EuAs and Eu(AsP)

Onuki, Yoshichika*; Karube, Kosuke*; Aoki, Dai*; Nakamura, Ai*; Homma, Yoshiya*; Matsuda, Tatsuma*; Haga, Yoshinori; Takeuchi, Tetsuya*

Journal of the Physical Society of Japan, 92(11), p.114703_1 - 114703_12, 2023/11

https://doi.org/10.7566/JPSJ.92.114703

Strain-induced crystallization and phase separation used for fabricating a tough and stiff slide-ring solid polymer electrolyte

Hashimoto, Kei*; Shiwaku, Toru*; Aoki, Hiroyuki; Yokoyama, Hideaki*; Mayumi, Koichi*; Ito, Kozo*

Science Advances (Internet), 9(47), p.eadi8505_1 - eadi8505_8, 2023/11

https://doi.org/10.1126/sciadv.adi8505

Fuel unloading work in decommissioning of the prototype fast breeder reactor Monju; First stage of Monju decommissioning project

Shiota, Yuki; Kudo, Junki; Tsuno, Hiromi; Takeuchi, Ryotaro; Ariyoshi, Hideo; Shiohama, Yasutaka; Hamano, Tomoharu; Takagi, Tsuyohiko; Nagaoki, Yoshihiro

JAEA-Technology 2023-002, 87 Pages, 2023/06

JAEA-Technology-2023-002.pdf:8.53MB

In the first stage of Monju decommissioning project, fuel unload work began to be carried out. There are two tasks in this work. One is Fuel Treatment and Storage work that gets rid of sodium on the fuel assemblies unloaded from Ex-Vessel fuel Storage Tank (EVST) and carries it in the storage pool, and the other is Fuel Unloading that the fuel assemblies in the reactor core is replaced with dummy fuels and stored in EVST. Fuel Treatment and Storage work and Fuel Unloading work are performed alternately, and 370 fuel assemblies in the core and 160 fuel assemblies in EVST are all carried to the storage pool. Monju had a large amount of sodium in the reactor vessel and EVST, and there was a residual risk of fuel failure due to the superposition of a large scale sodium fire. Therefore, in the first stage of the Monju decommissioning project, it was decided to take about 5.5 years to remove the residual risk by storing all the fuel rods in the fuel storage pool. There are few Fuel handling system of Sodium Fast Reactor in the world, so the driving record and experience are not enough. So, events that occur even if taken measure are assumed. The following three events apply to this; first, events that are difficult to prevent, events. Second, that are due to lack of experience, and final, events optimization of system is not enough. Plans were taken to suppress these events. This report summarizes the "Monju decommissioning project" work conducted so far in all four campaigns.

Low-temperature magnetic fluctuations investigated by Te-NMR on the uranium-based superconductor UTe

Fujibayashi, Hiroki*; Kinjo, Katsuki*; Nakamine, Genki*; Kitagawa, Shunsaku*; Ishida, Kenji*; Tokunaga, Yo; Sakai, Hironori; Kambe, Shinsaku; Nakamura, Ai*; Shimizu, Yusei*; et al.

Journal of the Physical Society of Japan, 92(5), p.053702_1 - 053702_5, 2023/05

https://doi.org/10.7566/JPSJ.92.053702

Field induced multiple superconducting phases in UTe along hard magnetic axis

Sakai, Hironori; Tokiwa, Yoshifumi; Opletal, P.; Kimata, Motoi*; Awaji, Satoshi*; Sasaki, Takahiko*; Aoki, Dai*; Kambe, Shinsaku; Tokunaga, Yo; Haga, Yoshinori

Physical Review Letters, 130(19), p.196002_1 - 196002_6, 2023/05

https://doi.org/10.1103/PhysRevLett.130.196002

The superconducting (SC) phase diagram in uranium ditelluride is explored under magnetic fields () along the hard magnetic -axis using a high-quality single crystal with = 2.1 K. Simultaneous electrical resistivity and AC magnetic susceptibility measurements discern low- and high-field SC (LFSC and HFSC, respectively) phases with contrasting field-angular dependence. Crystal quality increases the upper critical field of the LFSC phase, but the of T, at which the HFSC phase appears, is always the same through the various crystals. A phase boundary signature is also observed inside the LFSC phase near , indicating an intermediate SC phase characterized by small flux pinning forces.

Development of safety design philosophy of HTTR-Heat Application Test Facility

Aoki, Takeshi; Shimizu, Atsushi; Noguchi, Hiroki; Kurahayashi, Kaoru; Yasuda, Takanori; Nomoto, Yasunobu; Iigaki, Kazuhiko; Sato, Hiroyuki; Sakaba, Nariaki

Proceedings of 30th International Conference on Nuclear Engineering (ICONE30) (Internet), 9 Pages, 2023/05

The safety design philosophy is developed for the HTTR (High Temperature Engineering Test Reactor) heat application test facility connecting high temperature gas-cooled reactor (HTGR) and the hydrogen production plant. The philosophy was proposed to apply proven conventional chemical plant standards to the hydrogen production facility for ensuring public safety against anticipated disasters caused by high pressure and combustible gases. The present study also proposed the safety design philosophy to meet specific safety requirements identified to the nuclear facilities with coupling to the hydrogen production facility such as measures to ensure a capability of normal operation of the nuclear facility against a fire and/or explosion of leaked combustible material, and fluctuation of amount of heat removal occurred in the hydrogen production plant. The safety design philosophy will be utilized to establish its basic and detailed designs of the HTTR-heat application test facility.

Development plan for coupling technology between high temperature gas-cooled reactor HTTR and Hydrogen Production Facility, 2; Development plan for coupling equipment between HTTR and Hydrogen Production Facility

Mizuta, Naoki; Morita, Keisuke; Aoki, Takeshi; Okita, Shoichiro; Ishii, Katsunori; Kurahayashi, Kaoru; Yasuda, Takanori; Tanaka, Masato; Isaka, Kazuyoshi; Noguchi, Hiroki; et al.

Proceedings of 30th International Conference on Nuclear Engineering (ICONE30) (Internet), 6 Pages, 2023/05