Battery-free, skin-interfaced microfluidic/electronic systems for simultaneous electrochemical, colorimetric, and volumetric analysis of sweat

Bandodkar, A. J.*; Gutruf, P.*; Choi, J.*; Lee, K.-H.*; Sekine, Yurina; Reeder, J. T.*; Jeang, W. J.*; Aranyosi, A. J.*; Lee, S. P.*; Model, J. B.*; et al.

Science Advances (Internet), 5(1), p.eaav3294_1 - eaav3294_15, 2019/01

https://doi.org/10.1126/sciadv.aav3294

Interest in advanced wearable technologies increasingly extends beyond systems for biophysical measurements to those that enable continuous, non-invasive monitoring of biochemical markers in biofluids. Here, we introduce battery-free, wireless microelectronic platforms that perform sensing via schemes inspired by the operation of biofuel cells. Combining these systems in a magnetically releasable manner with chrono-sampling microfluidic networks that incorporate assays based on colorimetric sensing yields thin, flexible, lightweight, skin-interfaced technologies with broad functionality in sweat analysis. A demonstration device allows simultaneous monitoring of sweat rate/loss, along with quantitative measurements of pH and of lactate, glucose and chloride concentrations using biofuel cell and colorimetric approaches.

Projection imaging with directional electron and proton beams emitted from an ultrashort intense laser-driven thin foil target

Nishiuchi, Mamiko; Choi, I. W.*; Daido, Hiroyuki; Nakamura, Tatsufumi*; Pirozhkov, A. S.; Yogo, Akifumi*; Ogura, Koichi; Sagisaka, Akito; Orimo, Satoshi; Daito, Izuru*; et al.

Plasma Physics and Controlled Fusion, 57(2), p.025001_1 - 025001_9, 2015/02

https://doi.org/10.1088/0741-3335/57/2/025001

Projection images of a metal mesh produced by directional MeV electron beam together with directional proton beam, emitted simultaneously from a thin foil target irradiated by an ultrashort intense laser. The mesh patterns are projected to each detector by the electron beam and the proton beam originated from tiny virtual sources of 20 micron meter and 10 micron meter diameters, respectively. Based on the observed quality and magnification of the projection images, we estimate sizes and locations of the virtual sources for both beams and characterize their directionalities. To carry out physical interpretation of the directional electron beam qualitatively, we perform 2D particle-in-cell simulation which reproduces a directional escaping electron component, together with a non-directional dragged-back electron component, the latter mainly contributes to building a sheath electric field for proton acceleration.

Laser-driven proton generation with a thin-foil target

Sagisaka, Akito; Pirozhkov, A. S.; Mori, Michiaki; Yogo, Akifumi; Ogura, Koichi; Orimo, Satoshi; Nishiuchi, Mamiko; Ma, J.*; Kiriyama, Hiromitsu; Kanazawa, Shuhei; et al.

NIFS-PROC-85, p.30 - 33, 2011/02

http://www.nifs.ac.jp/report/nifs-proc85.html

The experiment of proton generation is performed for developing the laser-driven ion source. We observe proton signals in the laser-plasma interaction by using a thin-foil target. To get higher energy protons the size of the preformed plasma is reduced by changing the laser contrast level. In the high-contrast laser pulse case the maximum energy of the protons generated at rear side of the target increases.

New method to measure the rise time of a fast pulse slicer for laser ion acceleration research

Mori, Michiaki; Yogo, Akifumi; Kiriyama, Hiromitsu; Nishiuchi, Mamiko; Ogura, Koichi; Orimo, Satoshi; Ma, J.*; Sagisaka, Akito; Kanazawa, Shuhei; Kondo, Shuji; et al.

IEEE Transactions on Plasma Science, 36(4), p.1872 - 1877, 2008/08

https://doi.org/10.1109/TPS.2008.2000886

A dependence of cut-off proton kinetic energy on laser prepulse duration has been observed. ASE pedestal duration is controlled by a fast electro-optic pulse slicer where the risetime is estimated to be 130 ps. We demonstrate a new correlated spectral technique for determining this risetime using a stretched, frequency chirped pulse.

Laser prepulse dependency of proton-energy distributions in ultraintense laser-foil interactions with an online time-of-flight technique

Yogo, Akifumi; Daido, Hiroyuki; Fukumi, Atsushi*; Li, Z.*; Ogura, Koichi; Sagisaka, Akito; Pirozhkov, A. S.; Nakamura, Shu*; Iwashita, Yoshihisa*; Shirai, Toshiyuki*; et al.

Physics of Plasmas, 14(4), p.043104_1 - 043104_6, 2007/04

https://doi.org/10.1063/1.2721066

Fast protons are observed by a newly-developed time-of-flight spectrometer, which provides proton-energy distributions immediately after the irradiation of a laser pulse having an intensity of W/cm onto a 5-m-thick copper foil. The maximum proton energy is found to increase when the intensity of a fs-prepulse arriving 9 ns before the main pulse increases from 10 to 10 W/cm. Interferometric measurement indicates that the preformed-plasma expansion at the front surface is smaller than 15 m, which corresponds to the spatial resolution of the diagnostics. This sharp gradient of the plasma makes a beneficial effect on increasing the absorption efficiency of the main-pulse energy, resulting in the increase in the proton energy. This is supported by the result that the X-ray intensity from the laser plasma clearly increases with the prepulse intensity.

Resonant photoemission spectroscopy study of impurity-induced melting in Cr- and Ru-doped NdAMnO (A=Ca,Sr)

Kang, J.-S.*; Kim, J. H.*; Sekiyama, Akira*; Kasai, Shuichi*; Suga, Shigemasa*; Han, S. W.*; Kim, K. H.*; Choi, E. J.*; Kimura, Tsuyoshi*; Muro, Takayuki*; et al.

Physical Review B, 68(1), p.012410_1 - 012410_4, 2003/07

A2003-0329.pdf:0.49MB

https://doi.org/10.1103/PhysRevB.68.012410

no abstracts in English

Simultaneous imaging with a proton beam and an X-ray driven by a fs-intense laser

Orimo, Satoshi; Yogo, Akifumi; Ogura, Koichi; Sagisaka, Akito; Mori, Michiaki; Kiriyama, Hiromitsu; Kondo, Shuji; Yamamoto, Yoichi*; Shimomura, Takuya*; Tanoue, Manabu*; et al.

no journal, , 

We are investigating an intense fs-laser driven MeV proton source using a thin foil, and its applications. Simultaneous imaging of a sample with a proton and an X-ray beams has been demonstrated by a ultra-short pulse higt intensity Ti:Sapphire laser systems at JAEA and GIST. For generating a short-pulse proton beams and X-rays, an intense laser pulse irradiates a tape targets. The p-polarized laser pulse with 50 mm diameter is focused onto the cupper tape target at 45 degree incident angle with focal length of 238 mm (F/4.8), giving an intensity on target of 3-910W/cm10. The cupper and polyimide tape was 5, 7.5 micron in thickness and 20 mm in width. The target system supplies a fresh surface to the focus spot at every shot. We obtained simultaneously the projection image of a Ni mesh pattern having a periodically structured pattern by the proton detected CR39 and X-rays detected on imaging plate.

Activity produced by laser induced proton beams

Ogura, Koichi; Shizuma, Toshiyuki; Hayakawa, Takehito; Orimo, Satoshi; Sagisaka, Akito; Nishiuchi, Mamiko; Mori, Michiaki; Yogo, Akifumi; Pirozhkov, A. S.; Sugiyama, Hironori*; et al.

no journal, , 

Ultrashort and high intensity laser can induce high energy protons. Proton beams have a wide range of applications such as in the production of radioisotopes and proton therapy. An energy of the proton beam has a wide distribution. The distribution of activity in depth is calculated while laser induced protons are injected into an iron plate.