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Journal Articles

Radon inhalation decreases DNA damage induced by oxidative stress in mouse organs via the activation of antioxidative functions

Kataoka, Takahiro*; Shuto, Hina*; Naoe, Shota*; Yano, Junki*; Kanzaki, Norie; Sakoda, Akihiro; Tanaka, Hiroshi; Hanamoto, Katsumi*; Mitsunobu, Fumihiro*; Terato, Hiroaki*; et al.

Journal of Radiation Research (Internet), 62(5), p.861 - 867, 2021/09

 Times Cited Count:5 Percentile:55.27(Biology)

Journal Articles

Evaluation of the redox state in mouse organs following radon inhalation

Kataoka, Takahiro*; Kanzaki, Norie; Sakoda, Akihiro; Shuto, Hina*; Yano, Junki*; Naoe, Shota*; Tanaka, Hiroshi; Hanamoto, Katsumi*; Terato, Hiroaki*; Mitsunobu, Fumihiro*; et al.

Journal of Radiation Research (Internet), 62(2), p.206 - 216, 2021/03

AA2020-0273.pdf:1.2MB

 Times Cited Count:6 Percentile:61.83(Biology)

Radon inhalation activates antioxidative functions in mouse organs, thereby contributing to inhibition of oxidative stress-induced damage. Therefore, in this study, we evaluated the redox state of various organs in mice following radon inhalation. Mice inhaled radon at concentrations of 2 or 20 kBq/m$$^{3}$$ for 1, 3, or 10 days. The relationship between antioxidative function and oxidative stress was evaluated by principal component analysis (PCA) and correlation coefficient compared with control mice subjected to sham inhalation. These findings suggested that radon inhalation altered the redox state in organs, but that the characteristics varied depending on the redox state in organs.

JAEA Reports

Clearance of concrete generated from modification activities of JRR-3; Results for measuring and evaluating radioactivity concentration

Ogoshi, Yurie; Satoyama, Tomonori; Kishimoto, Katsumi; Nanri, Tomohiro; Suzuki, Takeshi; Tomioka, Osamu; Takaizumi, Hirohide*; Kanno, Tomoyuki*; Maruyama, Tatsuya*

JAEA-Technology 2017-017, 152 Pages, 2017/08

JAEA-Technology-2017-017.pdf:15.97MB

At Nuclear Science Research Institute, clearance works for about 4,000 tons of extremely low-level radioactive concrete debris, which were generated from the modification activities of JRR-3 from FY 1985 to FY 1989 and stored in the waste storage facility NL, carried out. First of this clearance works, method for measuring and evaluating radioactivity concentration was approved by Minister of MEXT on July 25, 2008. And then, clearance works were started from FY 2009. Measuring and evaluating radioactivity concentration was achieved by using the approved method, and was confirmed by government. And then, clearance works were completed in FY 2014. The clearance concrete was recycled as a material for restoration works of the 2011 off the Pacific coast of Tohoku Earthquake. This report summarizes the results of measuring and evaluating radioactivity concentration, achievement of confirmation by government, recycling of cleared concrete and cost for clearance works.

Journal Articles

Resonant X-ray diffraction study of multipole ordering in the ferromagnetic compound CePd$$_3$$S$$_4$$

Michimura, Shinji*; Inami, Toshiya; Matsuoka, Eiichi*; Watahiki, Masanori*; Tanigaki, Katsumi*; Onodera, Hideya*

Journal of the Physical Society of Japan, 81(4), p.044711_1 - 044711_5, 2012/04

 Times Cited Count:4 Percentile:32.96(Physics, Multidisciplinary)

Resonant X-ray diffraction experiments on CePd$$_3$$S$$_4$$ were performed at the Ce-$$L$$$$_{3}$$ absorption edge to study the states of quadrupolar ordering below the ferromagnetic transition temperature $$T_{rm C}$$ = 6.3 K. The magnetic structure of CePd$$_3$$S$$_4$$ was reported as a canted ferromagnetic structure with a canting angle of 51$$^circ$$. It has therefore been pointed out that the complex magnetic structure arises from the simultaneous ordering of quadrupole moments. We observed the azimuthal angle dependence of the diffraction intensity of the two forbidden reflections 003 and 104 reflections for both $$pi$$-$$pi$$' and $$pi$$-$$sigma$$' scattering processes. The results revealed that $$O$$$$_2$$$$^{0}$$-type antiferroquadrupolar ordering coexists with magnetic ordering. We infer that the magnetic structure of CePd$$_3$$S$$_4$$ is not a canted structure but a ferrimagnetic structure and that the quadrupole moment is also a primary-order parameter.

Journal Articles

Basic study on positive effects of radon inhalation on pet's health

Kataoka, Takahiro*; Tokunaga, Rikizo*; Sakoda, Akihiro; Kawabe, Atsushi*; Hanamoto, Katsumi*; Yamaoka, Kiyonori*

Radioisotopes, 61(1), p.1 - 8, 2012/01

Radon inhalation using our radon exposure device activated anti-oxidative function in some organs of mouse. To assess the possibility of its application to veterinary care, healthy dogs and cats with chronic renal failure were inhaled radon at a concentration of 5500 Bq/m$$^{3}$$ for 30 minutes every 2 days for 30 days. In result, radon inhalation within a relatively long time period significantly decreased the triglyceride level of dogs. On the other hand, some cats increased the volume of drinking water by radon inhalation and the creatinine level in blood of these cats was decreased to normal level. These findings suggest that radon inhalation may have curative properties against chronic renal failure.

Journal Articles

A Comparative study on effect of continuous radon inhalation on several-time acute alcohol-induced oxidative damages of liver and brain in mouse

Kataoka, Takahiro*; Sakoda, Akihiro*; Yoshimoto, Masaaki*; Toyota, Teruaki*; Yamamoto, Yuki*; Ishimori, Yuu; Hanamoto, Katsumi*; Kawabe, Atsushi*; Mitsunobu, Fumihiro*; Yamaoka, Kiyonori*

Radiation Safety Management, 10(1), p.1 - 7, 2011/12

We examined the effect of continuous radon inhalation on acute alcohol-induced oxidative damage of mouse liver and brain. Assay of antioxidative functions indicated that lipid peroxide levels in both the liver and brain of the alcohol-treated mice were significantly higher than those of the saline-treated mice. However, the lipid peroxide level in the liver, but not in the brain, of alcohol-treated mice was significantly decreased by radon inhalation whereas that in the brain of saline-treated mice, but not in the liver of saline-treated mice, was significantly increased by radon inhalation. These findings suggest that radon inhalation inhibits alcohol-induced oxidative damage of liver due to activation of antioxidative functions and that radon inhalation exert only a week effect on the brains in comparing with the livers. They further suggest that alcohol administration protects against oxidative damage of the brain that is induced by radon inhalation.

Journal Articles

Studies on possibility for alleviation of lifestyle diseases by low-dose irradiation or radon inhalation

Kataoka, Takahiro*; Sakoda, Akihiro*; Yoshimoto, Masaaki*; Nakagawa, Shinya*; Toyota, Teruaki*; Nishiyama, Yuichi*; Yamato, Keiko*; Ishimori, Yuu; Kawabe, Atsushi*; Hanamoto, Katsumi*; et al.

Radiation Protection Dosimetry, 146(1-3), p.360 - 363, 2011/07

 Times Cited Count:6 Percentile:44.28(Environmental Sciences)

Our previous studies showed the possibility that activation of the antioxidative function alleviates various oxidative damages, which are related to lifestyle diseases. Results showed that, low-dose X-ray irradiation activated superoxide dismutase and inhibits oedema following ischaemia-reperfusion. To alleviate ischaemia-reperfusion injury with transplantation, the changes of the antioxidative function in liver graft using low-dose X-ray irradiation immediately after exenteration were examined. Results showed that liver grafts activate the antioxidative function as a result of irradiation. In addition, radon inhalation enhances the antioxidative function in some organs, and alleviates alcohol-induced oxidative damage of mouse liver. Moreover, in order to determine the most effective condition of radon inhalation, mice inhaled radon before or after carbon tetrachloride (CCl$$_{4}$$) administration. Results showed that radon inhalation alleviates CCl$$_{4}$$-induced hepatopathy, especially prior inhalation. It is highly possible that adequate activation of antioxidative functions induced by low-dose irradiation can contribute to preventing or reducing oxidative damages, which are related to lifestyle diseases.

Journal Articles

Applicability and performance of an imaging plate at subzero temperatures

Sakoda, Akihiro*; Ishimori, Yuu; Hanamoto, Katsumi*; Kawabe, Atsushi*; Kataoka, Takahiro*; Nagamatsu, Tomohiro*; Yamaoka, Kiyonori*

Applied Radiation and Isotopes, 68(10), p.2013 - 2015, 2010/10

 Times Cited Count:1 Percentile:9.99(Chemistry, Inorganic & Nuclear)

The performance of IPs has not been studied at temperatures lower than 0$$^{circ}$$C. In the present study, an IP was irradiated with $$gamma$$ rays emitted from the mineral monazite at temperatures between -80 and 30$$^{circ}$$C to determine its fundamental properties. The IP response as a function of irradiation time was found to be linear, suggesting that the IP works properly at low temperatures. Fading, an effect which should be considered at temperatures of more than 0$$^{circ}$$C, was not observed at -30 and -80$$^{circ}$$C. Furthermore, the fading-corrected PSL value of the IP irradiated at -80$$^{circ}$$C was lower than at other temperatures (30, 5 and -30$$^{circ}$$C). This can be explained by TSL. Since the only intensive TSL peak in the temperature range from -80 to 30$$^{circ}$$C is present at about -43$$^{circ}$$C, some of the electrons trapped at F centers recombine with holes through the process of TSL before the stored radiation image is read out at room temperature.

Journal Articles

Physiologically based pharmacokinetic modeling of inhaled radon to calculate absorbed doses in mice, rats, and humans

Sakoda, Akihiro*; Ishimori, Yuu; Kawabe, Atsushi*; Kataoka, Takahiro*; Hanamoto, Katsumi*; Yamaoka, Kiyonori*

Journal of Nuclear Science and Technology, 47(8), p.731 - 738, 2010/08

 Times Cited Count:42 Percentile:93.07(Nuclear Science & Technology)

This is the first report to provide radiation doses, arising from inhalation of radon itself, in mice and rats. To quantify absorbed doses to organs and tissues in mice, rats, and humans, we computed the behavior of inhaled radon in their bodies on the basis of a physiologically based pharmacokinetic (PBPK) model. It was assumed that radon dissolved in blood entering the gas exchange compartment is transported to any tissue by the blood circulation to be instantaneously distributed according to a tissue/blood partition coefficient. The calculated concentrations of radon in the adipose tissue and red bone marrow following its inhalation were much higher than those in the others, because of the higher partition coefficients. Compared with a previous experimental data for rats and model calculation for humans, the present calculation was proved to be valid. Absorbed dose rates to organs and tissues were estimated to be within the range of 0.04 - 1.4 nGy/(Bq/m$$^{-3}$$)/day for all the species.

Journal Articles

First model of the effect of grain size on radon emanation

Sakoda, Akihiro*; Hanamoto, Katsumi*; Ishimori, Yuu; Kataoka, Takahiro*; Kawabe, Atsushi*; Yamaoka, Kiyonori*

Applied Radiation and Isotopes, 68(6), p.1169 - 1172, 2010/06

 Times Cited Count:31 Percentile:88.56(Chemistry, Inorganic & Nuclear)

The present model represents an improvement on previous models of radon emanation from soil by incorporating soil grain size in addition to moisture. Monte Carlo simulation was employed in the calculation since it was difficult to mathematically express the radon emanation fraction for the present soil model. Grain size is one of the most important factors in describing the properties of soil. Grain size was demonstrated to affect the radon emanation fraction, depending on moisture content. Although the emanation fraction is generally considered to be proportional to grain size, the result of the model calculation suggested that the effect of grain size is not so simple. This study should serve as an initial step toward improving the modeling of this radon emanation.

Journal Articles

Differences of natural radioactivity and radon emanation fraction among constituent minerals of rock or soil

Sakoda, Akihiro*; Nishiyama, Yuichi*; Hanamoto, Katsumi*; Ishimori, Yuu; Yamamoto, Yuki*; Kataoka, Takahiro*; Kawabe, Atsushi*; Yamaoka, Kiyonori*

Applied Radiation and Isotopes, 68(6), p.1180 - 1184, 2010/06

 Times Cited Count:53 Percentile:95.31(Chemistry, Inorganic & Nuclear)

We examined differences in the radioactive characteristics among the main minerals forming granite materials. Using a non-toxic high-density agent, minerals were separated from rock (granite-gneiss) and soil (weathered granite) samples. The natural radioactivity ($$^{238}$$U and $$^{226}$$Ra) and radon emanation fraction of the minerals were then studied by $$gamma$$-ray spectrometry. The radon emanation fractions (27-43%) of the minerals from the soil were much higher than those (0.6-4.6%) of the rock minerals. Additionally, the emanation fractions differed greatly among the minerals separated from both the bulk rock and soil. These results were discussed in terms of the differences of surface area and radium distribution in the mineral grains. It was noticeable that a higher emanation fraction than expected for quartz was commonly observed in the rock and soil samples. We then estimated the contribution of each constituent mineral to the total radon exhalation from the bulk samples. The result depended not only on the radon emanation fraction, but also on the $$^{226}$$Ra activity and the mineral content. Furthermore, using the obtained data, we also discussed the effect of grain size on radon emanation and why this has been reported to vary markedly in previous studies.

Journal Articles

Recent progress in the energy recovery linac project in Japan

Sakanaka, Shogo*; Akemoto, Mitsuo*; Aoto, Tomohiro*; Arakawa, Dai*; Asaoka, Seiji*; Enomoto, Atsushi*; Fukuda, Shigeki*; Furukawa, Kazuro*; Furuya, Takaaki*; Haga, Kaiichi*; et al.

Proceedings of 1st International Particle Accelerator Conference (IPAC '10) (Internet), p.2338 - 2340, 2010/05

Future synchrotron light source using a 5-GeV energy recovery linac (ERL) is under proposal by our Japanese collaboration team, and we are conducting R&D efforts for that. We are developing high-brightness DC photocathode guns, two types of cryomodules for both injector and main superconducting (SC) linacs, and 1.3 GHz high CW-power RF sources. We are also constructing the Compact ERL (cERL) for demonstrating the recirculation of low-emittance, high-current beams using above-mentioned critical technologies.

Journal Articles

Experimental and modeling studies of grain size and moisture content effects on radon emanation

Sakoda, Akihiro*; Ishimori, Yuu; Hanamoto, Katsumi*; Kataoka, Takahiro*; Kawabe, Atsushi*; Yamaoka, Kiyonori*

Radiation Measurements, 45(2), p.204 - 210, 2010/02

 Times Cited Count:61 Percentile:96.44(Nuclear Science & Technology)

Some models have already been developed to explain the effect of moisture content on the radon emanation fraction of soil. For this purpose, "microscopic" soil models, which are easy to deal with mathematically but cannot take grain size into consideration, have been designed. These previous models consist basically of two opposite grain surfaces and pores between the grains. In the present study, in order to study the effect of not only moisture content but also grain size, we present a simple modeling approach based on two "macroscopic" soil models: (1) a single-grain model and (2) a multiple-grain model. The latter model represents a configuration of spherical grains packed in a simple cubic structure. Based on these soil models and general assumptions, the radon emanation fraction was calculated as a function of grain size or moisture content by Monte Carlo simulation. The results for the multiple-grain model show that the radon emanation fraction is markedly increased with grain sizes ranging from 10 to 100 mm and reaches a constant value of 50% when moisture content is 0% and the radium is uniformly distributed on the grain surface. Moreover, a drastic increase is seen at smaller grain sizes with increasing moisture content. From these results, we concluded that the calculation of radon emanation depends greatly on the pore size between a Ra-bearing grain and a neighboring grain. The validity of the model was also evaluated by comparison to experimental data.

Journal Articles

Dynamics of ion internal transport barrier in LHD heliotron and JT-60U tokamak plasmas

Ida, Katsumi*; Sakamoto, Yoshiteru; Yoshinuma, Mikiro*; Takenaga, Hidenobu; Nagaoka, Kenichi*; Hayashi, Nobuhiko; Oyama, Naoyuki; Osakabe, Masaki*; Yokoyama, Masayuki*; Funaba, Hisamichi*; et al.

Nuclear Fusion, 49(9), p.095024_1 - 095024_9, 2009/09

 Times Cited Count:29 Percentile:72.01(Physics, Fluids & Plasmas)

Dynamics of ion internal transport barrier (ITB) formation and impurity transport both in the Large Helical Device (LHD) heliotron and JT-60U tokamak are described. Significant differences between heliotron and tokamak plasmas are observed. The location of the ITB moves outward during the ITB formation regardless of the sign of magnetic shear in JT-60U and the ITB becomes more localized in the plasma with negative magnetic shear. In LHD, the low Te/Ti ratio ($$<$$ 1) of the target plasma for the high power heating is found to be necessary condition to achieve the ITB plasma and the ITB location tends to expand outward or inward depending on the condition of the target plasmas. Associated with the formation of ITB, the carbon density tends to be peaked due to inward convection in JT-60U, while the carbon density becomes hollow due to outward convection in LHD. The outward convection observed in LHD contradicts the prediction by neoclassical theory.

JAEA Reports

Modification of the drift ducts reionization loss estimation for JT-60U NBI

Kawai, Mikito; Akino, Noboru; Ikeda, Yoshitaka; Ebisawa, Noboru; Honda, Atsushi; Kazawa, Minoru; Kikuchi, Katsumi; Mogaki, Kazuhiko; Noto, Katsuya; Oshima, Katsumi; et al.

JAEA-Technology 2008-069, 32 Pages, 2008/10

JAEA-Technology-2008-069.pdf:6.75MB

The neutral beam injection system for JT-60U consists of positive-ion based type(P-NBI) and negative-ion based type(N-NBI). The reionization losses of neutral beams in the drift ducts of both P-NBI and N-NBI are estimated using the data of ambient pressure and gas flow rate into the beamlines. This system was not enough to obtain detail injection power for a long pulse operation. Modifications of the system to obtain reionization loss for a long pulse operation have been conducted. The new system has a capability to measure the pressures of drift duct during operation. The system can calculate the reionization loss automatically during the pulse from the measured pressure. More acurate injection power can be obtained by this new system.

Journal Articles

Experimental investigation of particle pinch associated with turbulence in LHD heliotron and JT-60U tokamak plasmas

Tanaka, Kenji*; Takenaga, Hidenobu; Muraoka, Katsunori*; Michael, C.*; Vyacheslavov, L. N.*; Yokoyama, Masayuki*; Yamada, Hiroshi*; Oyama, Naoyuki; Urano, Hajime; Kamada, Yutaka; et al.

Proceedings of 22nd IAEA Fusion Energy Conference (FEC 2008) (CD-ROM), 8 Pages, 2008/10

Comparative studies were carried out in LHD heliotron and JT-60U tokamak plasmas to elucidate the most essential parameter(s) for control of density profiles in toroidal systems. A difference in the collisionality dependence was found between the two devices. In LHD, the density peaking factor decreased with decrease of the collisionality at the magnetic axis position (R$$_{rm au}$$) 3.6 m, while the density peaking factor gradually increased with a decreased of collisionality at R$$_{rm au}$$ = 3.5 m. On the other hand, in JT-60U, the density peaking factor clearly increased with a decrease of the collisionality. The difference in the collisionality dependence between R$$_{rm au}$$ = 3.5 and R$$_{rm au}$$ = 3.6 m is likely due to the contribution of the anomalous transport. At R$$_{rm au}$$ = 3.5 m, larger anomalous transport caused a similar collisionality dependence. Change of the fluctuation property was observed with different density profiles in the plasma core region on both devices. In JT-60U, the increase of the radial coherence was observed with higher density peaking profile suggesting enhanced diffusion and inward directed pinch. For a magnetic axis positions (R$$_{rm au}$$) at 3.6 m in LHD, the increase of the fluctuation power with an increase in P$$_{rm NB}$$ was observed for a hollow density profile suggesting an increase on diffusion due to anomalous processes. Change of density profiles from peaked to hollow indicates change in the convection direction. This is due to increase in neoclassical processes. The reduction of the density peaking factor with increase of P$$_{rm NB}$$ in LHD is partly due to the neoclassical effect and partly due to the anomalous effect.

Journal Articles

Particle transport and fluctuation characteristics around the neoclassically optimized configurations in LHD

Tanaka, Kenji*; Michael, C.*; Vyacheslavov, L. N.*; Yokoyama, Masayuki*; Murakami, Sadayoshi*; Wakasa, Arimitsu*; Takenaga, Hidenobu; Muraoka, Katsunori*; Kawahata, Kazuo*; Tokuzawa, Tokihiko*; et al.

Plasma and Fusion Research (Internet), 3, p.S1069_1 - S1069_7, 2008/08

Density profiles in LHD were measured and particle transport coefficients were estimated from density modulation experiments in LHD. The dataset of different magnetic axis, toroidal magnetic filed and heating power provided data set of widely scanned neoclassical transport. At minimized neoclassical transport configuration ($$R$$$$_{rm ax}$$ = 3.5 m, $$B$$$$_{rm t}$$ = 2.8 T) showed peaked density profile. Its peaking factor increased gradually with decrease of collisional frequency. This is a similar result observed in JT-60U. At other configuration, peaking factor reduced with decrease of collsional frequency. Data set showed that larger contribution of neoclassical transport produced hollowed density profile. Comparison between neoclassical and estimated particle diffusivity showed different minimum condition. Clear difference of spatial profile of turbulence was observed between hollowed and peaked density profiles. Major part of fluctuation existed in the unstable region of ion temperature gradient mode.

Journal Articles

Radioactivity and radon emanation fraction of the granites sampled at Misasa and Badgastein

Sakoda, Akihiro*; Hanamoto, Katsumi*; Ishimori, Yuu; Nagamatsu, Tomohiro*; Yamaoka, Kiyonori*

Applied Radiation and Isotopes, 66(5), p.648 - 652, 2008/05

 Times Cited Count:34 Percentile:88.13(Chemistry, Inorganic & Nuclear)

The chemical composition was analyzed and the radioactivity, radon exhalation rate and emanation fraction were measured to investigate the characteristics of the granites sampled at Misasa and Badgastein, world famous for radon therapy. The Misasa granite was probably composed of quartz, albite and microcline. The Badgastein granite was probably composed of quartz and muscovite. The radon exhalation rates and emanation fractions of the Misasa granite were much higher than those of the Badgastein granite, regardless of the $$^{226}$$Ra activity concentrations.

Journal Articles

Basic study on activation of antioxidation function in some organs of mice by radon inhalation using new radon exposure device

Nakagawa, Shinya*; Kataoka, Takahiro*; Sakoda, Akihiro*; Ishimori, Yuu; Hanamoto, Katsumi*; Yamaoka, Kiyonori*

Radioisotopes, 57(4), p.241 - 251, 2008/04

There are a lot of life style diseases that are related to reactive oxygen species in inductions of the radon therapy, and the further clarification of mechanism is expected. In this study, we investigated the activation of antioxidation function in some organs of mice by radon inhalation using the new radon exposure device. The mice were made to inhale the radon of 400Bq/m$$^{3}$$ or 4000Bq/m$$^{3}$$ with the device. Results show that in brain, lungs, liver and kidney, both the activities of superoxide dismutase and catalase increased, and lipid peroxide levels decreased. This suggests that radon inhalation enhanced the antioxidation function. These findings are important in understanding the mechanism of diseases in which radon therapy is used as treatment, and most of which are called activated oxygen-related diseases.

Journal Articles

Effects of some physical conditions on leaching rate of radon from radioactive minerals originating from some hot springs

Sakoda, Akihiro*; Hanamoto, Katsumi*; Ishimori, Yuu; Nagamatsu, Tomohiro*; Yamaoka, Kiyonori*

Radiation Measurements, 43(1), p.106 - 110, 2008/01

 Times Cited Count:18 Percentile:72.86(Nuclear Science & Technology)

In order to determine the best physical conditions for leaching more radon from minerals into water, we measured the leaching rate of radon from radioactive minerals under the conditions of some different grain sizes and water temperatures. Water temperature affected the leaching rate of radon although the grain size did not significantly affect it. Furthermore, we proposed ultrasonic irradiation to the mixture of a mineral and water as the method of leaching more radon. Ultrasonic irradiation was efficient to leach more radon from the mineral soaked in water because of ultrasonic cavitation.

63 (Records 1-20 displayed on this page)