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Journal Articles

Sequence-dependent hydration water dynamics of dodecameric DNA

Nakagawa, Hiroshi; Yonetani, Yoshiteru*; Nakajima, Kenji; Kawamura, Seiko; Kikuchi, Tatsuya*; Inamura, Yasuhiro; Kataoka, Mikio*; Kono, Hidetoshi*

JPS Conference Proceedings (Internet), 33, p.011101_1 - 011101_6, 2021/03

Hydration water dynamics were measured by quasi-elastic neutron scattering with Hn$$_{2}$$O/D$$_{2}$$O contrast for two DNA dodecamers, 5'CGCG$$underline{rm AATT}$$CGCG'3 and 5'CGCG$$underline{rm TTAA}$$CGCG'3, which have been computationally shown to be structurally rigid and flexible, respectively. The dynamical transitions of the hydration water as well as DNA were observed for both sequences at approximately 240 K. Above the transition temperature, the mean square displacements of the hydration water for the rigid sequence were smaller than those for the flexible one. Furthermore, the relaxation time of the hydration water was longer in the rigid DNA than in the flexible DNA. We suggest that hydration water dynamics on the picosecond timescale are associated with sequence-dependent deformability of DNA.

Journal Articles

Nonhomologous end-joining repair plays a more important role than homologous recombination repair in defining radiosensitivity after exposure to high-LET radiation

Takahashi, Akihisa*; Kubo, Makoto*; Ma, H.*; Nakagawa, Akiko*; Yoshida, Yukari*; Isono, Mayu*; Kanai, Tatsuaki*; Ono, Tatsuya*; Furusawa, Yoshiya*; Funayama, Tomoo; et al.

Radiation Research, 182(3), p.338 - 344, 2014/09

 Times Cited Count:38 Percentile:87.69(Biology)

To clarify whether high-LET radiation inhibits all repair pathways or specifically one repair pathway, studies were designed to examine the effects of radiation with different LET values on DNA DSB repair and radiosensitivity. Embryonic fibroblasts bearing repair gene KO were exposed to X rays, carbon-, iron-, neon- and argon-ion beams. Cell survival was measured with colony-forming assays. The sensitization enhancement ratio (SER) values were calculated using the 10% survival dose of wild-type cells and repair-deficient cells. Cellular radiosensitivity was listed in descending order: double-KO cells $$>$$ NHEJ-KO cells $$>$$ HR-KO cells $$>$$ wild-type cells. Although HR-KO cells had an almost constant SER value, NHEJ-KO cells showed a high-SER value when compared to HR-KO cells, even with increasing LET values. These results suggest that with carbon-ion therapy, targeting NHEJ repair yields higher radiosensitivity than targeting homologous recombination repair.

Journal Articles

Local dynamics coupled to hydration water determines DNA-sequence-dependent deformability

Nakagawa, Hiroshi; Yonetani, Yoshiteru; Nakajima, Kenji; Kawamura, Seiko; Kikuchi, Tatsuya; Inamura, Yasuhiro; Kataoka, Mikio; Kono, Hidetoshi

Physical Review E, 90(2), p.022723_1 - 022723_11, 2014/08

 Times Cited Count:7 Percentile:50.1(Physics, Fluids & Plasmas)

Molecular dynamics (MD) simulations and Quasi-Elastic Neutron Scattering (QENS) experiments were conducted on hydrated two DNA dodecamers with distinct deformability; 5'CGCGAATTCGCG3' and 5'CGCGTTAACGCG3'. The former is known to be rigid and the latter to be flexible. The mean-square displacements (MSDs) of DNA dodecamers exhibit so-called dynamical transition around 200-240 K for both sequences. To investigate the DNA sequence dependent dynamics, the dynamics of DNA and hydration water above the transition temperature were examined using both MD simulations and QENS experiments. The fluctuation amplitude of the AATT central tetramer is smaller, and its relaxation time is longer, than that observed in TTAA, suggesting that the AT step is kinetically more stable than TA. The sequence-dependent local base pair step dynamics correlate with the kinetics of breaking the hydrogen bond between DNA and hydration water. The sequence dependent DNA base pair step fluctuations appear above the dynamical transition temperature. Together with these results, we conclude that DNA deformability is related to the local dynamics of base pair step, themselves coupled to hydration water in the minor groove.

Journal Articles

Increase in cell motility by carbon ion irradiation via the Rho signaling pathway and its inhibition by the ROCK inhibitor Y-27632 in lung adenocarcinoma A549 cells

Murata, Kazutoshi*; Noda, Shinei*; Oike, Takahiro*; Takahashi, Akihisa*; Yoshida, Yukari*; Suzuki, Yoshiyuki*; Ono, Tatsuya*; Funayama, Tomoo; Kobayashi, Yasuhiko; Takahashi, Takeo*; et al.

Journal of Radiation Research, 55(4), p.658 - 664, 2014/07

 Times Cited Count:15 Percentile:60.96(Biology)

The effect of carbon ion irradiation on cell motility through the Rho signaling pathway in the human lung adenocarcinoma cell line A549 was studied. At 48 h after irradiation, the cell motility of A549 cells became significantly greater, and the formation of protrusions significantly increased in cells irradiated with carbon ion. The observed increase in cell motility due to carbon ion irradiation was similar to that observed due to X-ray irradiation. Western-blot analysis showed that carbon ion irradiation increased P-MLC2-S19 expression compared with in unirradiated controls, while total MLC2 expression was unchanged. Exposure to a non-toxic concentration of Y-27632, a specific inhibitor of ROCK, reduced the expression of P-MLC2-S19 after C-ion irradiation, resulting in a significant reduction in migration. These data suggest that carbon irradiation increases cell motility in A549 cells via the Rho signaling pathway and that ROCK inhibition reduces that effect.

Journal Articles

Analysis on effects of transverse electric field in an injector cavity of compact-ERL at KEK

Hwang, J.-G.*; Kim, E.-S.*; Miyajima, Tsukasa*; Honda, Yosuke*; Harada, Kentaro*; Shimada, Miho*; Takai, Ryota*; Kume, Tatsuya*; Nagahashi, Shinya*; Obina, Takashi*; et al.

Nuclear Instruments and Methods in Physics Research A, 753, p.97 - 104, 2014/07

 Times Cited Count:7 Percentile:50.1(Instruments & Instrumentation)

Journal Articles

Identified charged hadron production in $$p + p$$ collisions at $$sqrt{s}$$ = 200 and 62.4 GeV

Adare, A.*; Afanasiev, S.*; Aidala, C.*; Ajitanand, N. N.*; Akiba, Yasuyuki*; Al-Bataineh, H.*; Alexander, J.*; Aoki, Kazuya*; Aphecetche, L.*; Armendariz, R.*; et al.

Physical Review C, 83(6), p.064903_1 - 064903_29, 2011/06

 Times Cited Count:156 Percentile:99.42(Physics, Nuclear)

Transverse momentum distributions and yields for $$pi^{pm}, K^{pm}, p$$, and $$bar{p}$$ in $$p + p$$ collisions at $$sqrt{s}$$ = 200 and 62.4 GeV at midrapidity are measured by the PHENIX experiment at the RHIC. We present the inverse slope parameter, mean transverse momentum, and yield per unit rapidity at each energy, and compare them to other measurements at different $$sqrt{s}$$ collisions. We also present the scaling properties such as $$m_T$$ and $$x_T$$ scaling and discuss the mechanism of the particle production in $$p + p$$ collisions. The measured spectra are compared to next-to-leading order perturbative QCD calculations.

Journal Articles

Azimuthal correlations of electrons from heavy-flavor decay with hadrons in $$p+p$$ and Au+Au collisions at $$sqrt{s_{NN}}$$ = 200 GeV

Adare, A.*; Afanasiev, S.*; Aidala, C.*; Ajitanand, N. N.*; Akiba, Yasuyuki*; Al-Bataineh, H.*; Alexander, J.*; Aoki, Kazuya*; Aphecetche, L.*; Aramaki, Y.*; et al.

Physical Review C, 83(4), p.044912_1 - 044912_16, 2011/04

 Times Cited Count:8 Percentile:52.71(Physics, Nuclear)

Measurements of electrons from the decay of open-heavy-flavor mesons have shown that the yields are suppressed in Au+Au collisions compared to expectations from binary-scaled $$p+p$$ collisions. Here we extend these studies to two particle correlations where one particle is an electron from the decay of a heavy flavor meson and the other is a charged hadron from either the decay of the heavy meson or from jet fragmentation. These measurements provide more detailed information about the interaction between heavy quarks and the quark-gluon matter. We find the away-side-jet shape and yield to be modified in Au+Au collisions compared to $$p+p$$ collisions.

Journal Articles

Radiation-induced ICAM-1 expression via TGF-$$beta$$1 pathway on human umbilical vein endothelial cells; Comparison between X-ray and carbon-ion beam irradiation

Kiyohara, Hiroki*; Ishizaki, Yasuki*; Suzuki, Yoshiyuki*; Kato, Hiroyuki*; Hamada, Nobuyuki*; Ono, Tatsuya*; Takahashi, Takeo*; Kobayashi, Yasuhiko; Nakano, Takashi*

Journal of Radiation Research, 52(3), p.287 - 292, 2011/03

 Times Cited Count:13 Percentile:52.22(Biology)

Journal Articles

Muon spin relaxation and hyperfine-enhanced $$^{141}$$Pr nuclear spin dynamics in Pr(Os,Ru)$$_4$$Sb$$_{12}$$ and (Pr,La)Os$$_4$$Sb$$_{12}$$

Shu, L.*; MacLaughlin, D. E.*; Aoki, Yuji*; Tsunashima, Yoshino*; Yonezawa, Yuki*; Sanada, Shotaro*; Kikuchi, Daisuke*; Sato, Hideyuki*; Heffner, R. H.; Higemoto, Wataru; et al.

Physical Review B, 76(1), p.014527_1 - 014527_8, 2007/07

 Times Cited Count:20 Percentile:65.43(Materials Science, Multidisciplinary)

Journal Articles

${it Klavier}$ (${it klv}$), a novel hypernodulation mutant of ${it Lotus japonicus}$ affected in vascular tissue organization and floral induction

Kira, Erika*; Tateno, Kumiko*; Miura, Kinichiro*; Haga, Tatsuya*; Hayashi, Masaki*; Harada, Kyuya*; Sato, Shusei*; Tabata, Satoshi*; Shikazono, Naoya; Tanaka, Atsushi; et al.

Plant Journal, 44(3), p.505 - 515, 2005/11

 Times Cited Count:85 Percentile:87.8(Plant Sciences)

no abstracts in English

Journal Articles

Use of liquid helium-3 as a neutron converter for a semiconductor-based neutron detector

Nakamura, Tatsuya; Katagiri, Masaki; Aratono, Yasuyuki; Kanno, Ikuo*; Hishiki, Shigeomi*; Sugiura, Osamu*; Murase, Yasuhiro*

Nuclear Instruments and Methods in Physics Research A, 529(1-3), p.399 - 401, 2004/08

 Times Cited Count:1 Percentile:10.64(Instruments & Instrumentation)

We evaluated the neutron-detection characteristics of a cryogenic neutron detector operating at 1.6 K, which comprises a liquid helium-3 as a neutron converter and an InSb semiconductor detector. The InSb semiconductor detector detected the protons created in the nuclear reaction $$^{3}He + n rightarrow p + T$$ in the liquid helium-3, where the density of that is ~600 times larger than that of the gaseous helium-3 at room temperature.

Journal Articles

Cryogenic neutron detector by InSb semiconductor detector with high-density helium-3 gas converter

Nakamura, Tatsuya; Katagiri, Masaki; Aratono, Yasuyuki; Kanno, Ikuo*; Hishiki, Shigeomi*; Sugiura, Osamu*; Murase, Yasuhiro*

Nuclear Instruments and Methods in Physics Research A, 520(1-3), p.76 - 79, 2004/03

 Times Cited Count:8 Percentile:50.96(Instruments & Instrumentation)

The neutron-detection characteristics of a cryogenic neutron detector comprising an InSb semiconductor detector and a helium-3 gas converter were evaluated at a gas pressure of up to 12.5atm at 4.2K. The detector successfully detected stable neutrons under these conditions, where the density of the helium-3 gas is a few-hundred times higher than that at room temperature. It was found that the neutron detection efficiency was correlated with the gas pressure - even in a backward-detection configuration - in low-temperature, high-pressure helium-3.

Journal Articles

Cryogenic neutron detector comprising an InSb semiconductor detector and a supercritical helium-3 gas converter

Nakamura, Tatsuya; Katagiri, Masaki; Aratono, Yasuyuki; Kanno, Ikuo*; Hishiki, Shigeomi*; Sugiura, Osamu*; Murase, Yasuhiro*

Review of Scientific Instruments, 75(2), p.340 - 344, 2004/02

 Times Cited Count:6 Percentile:37.25(Instruments & Instrumentation)

We evaluated the neutron-detection characteristics of a proposed cryogenic neutron detector comprising an InSb semiconductor detector and a helium-3 gas converter. The neutron detector was operated at 4.2 K with helium-3 gas filling up to 1.5 atm, at which the density of the helium-3 nucleus corresponds to that at 160 atm at room temperature. The secondary particles generated by the $$^{3}$$He(n,p) T reaction were successfully detected by the InSb detector with a time response of $$sim$$80 nsec at all tested gas pressures.

JAEA Reports

Development of Quality Assurance System for Resistance Welding by Ultrasonic Examination -Fabrication of STB for Resistance Welding and Ultrasonic Examination-

Kono, Shusaku; Seki, Masayuki; Fujio, Ishibashi,; Hirako, Kazuhiko*; Tsukada, Tatsuya*

JNC TN8430 2003-010, 28 Pages, 2003/07

JNC-TN8430-2003-010.pdf:2.18MB

The defect occurred at the resistance welding zone is very minute and therefore cannot be identified by X-ray inspection. Then, the ultrasonic examination method, in which the resolution of the defect is higher than that of the X-ray inspection method, has been developed. The ultrasonic wave sounds straight easier in the material than X rays, excels in defecting the micro defect. However, the pulse amplitude of ultrasonic wave is influenced by the shape and direction of the defect. Then, the ultrasonic inspection equipement, in which the ultrasonic probe and the sample rotation axis are controlled to drive with the pulse motor and the defect data (position and size)are analized by image processing ultrasonic signal, was developed to measure the shape and the position of defect accurately. However, an ultrasonic examination method is the comparative inspection method. Therefore, the standard test block or the reference block is indispensable to guarantee the defectability and the ultrasonic echo sensibility of the inspection device. The standard test block is provided in JIS etc, it is needed to defect the peculiar defect occurred at the resistance welding zone. Then, the method of processing a standard test block is examined, the standard test block was made experimentally by electric discharge processing and diffusion junction method. The ultrasonic echo sensitivity and the threshold for image processing were proofread by using the standard test block, the ultrasonic inspection and metallographic inspection were executed. Comparing the ultrasonic inspection results with the metallographic inspection results, the detectability of defect depth and the measurement accuracy were proved to be 3$$mu$$m and with errors less than 10$$mu$$m respectively. From these results, the effectireness of proofreading the ultrasonic inspection condition by the standard test block was confirmed. Moreover, it was confirmed that there was a peculiar relationship between the depth ...

JAEA Reports

Development of Resistance Welding Process(VI)

Kono, Shusaku; Seki, Masayuki; Ishibashi, Fujio; Hirako, Kazuhiko*; Tsukada, Tatsuya*

JNC TN8410 2003-009, 108 Pages, 2003/05

JNC-TN8410-2003-009.pdf:9.54MB

The welding condition and the heat-treatment condition were optimized to evaluate welding properties of the martensitic ODS steel cladding tube. The test pieces for evaluation of strength properties of the welded zone were produced by the optimized welding condition. In order to evaluate the strength of the welded zone, the internal creep rapture test, the single axis creep rapture test, the burst test and the tensile test were conducted. Following results were obtained in these tests. (1) Weld ability. An excellent welding characteristic was observed. The micro cracks, etc. were not served at the joint starting point. The joint starting poonts were connected uniformly with errors less than 0.05mm. It is considered that an excellent welding characteristic was result of homogeneous micro structure of cladding material. (2) End plug material. In case of the material of end plug was martensitic ODS steel as same as that of cladding tube, the micro structure and the precipitation state carbide near the welded zone were found to be almost same as that of cladding tube. (3) Optimization of heat-treatment condition. The heat treatments of normalizing (10501$$^{circ}$$C) and tempering (780$$^{circ}$$C) were performed after welding and the micro structure near the welded zone was the isometric structure with low dislocation density, the precipitation state of carbide was uniform as same as that of cladding tube. These heat treatments can relax the residual stress accumulated when welding; it is considered that these heat treatments after welding are indispensable. (4) Strength of welded zone. The strength of the welded zone was found to be equal to that of cladding tube in all the strength tests. Therefore, it is concluded that the welding technology for the martensitic ODS steel is completed.

JAEA Reports

Questionnaire on the measurement condition of distribution coefficient

Takebe, Shinichi; Kimura, Hideo; Matsuzuru, Hideo; Takahashi, Tomoyuki*; Yasuda, Hiroshi*; Uchida, Shigeo*; Mahara, Yasunori*; Saeki, Akiyoshi*; Sasaki, Noriyuki*; Ashikawa, Nobuo*; et al.

JAERI-Review 2001-015, 81 Pages, 2001/05

JAERI-Review-2001-015.pdf:5.94MB

no abstracts in English

Journal Articles

Progress of the ITER central solenoid model coil programme

Tsuji, Hiroshi; Okuno, Kiyoshi*; Thome, R.*; Salpietro, E.*; Egorov, S. A.*; Martovetsky, N.*; Ricci, M.*; Zanino, R.*; Zahn, G.*; Martinez, A.*; et al.

Nuclear Fusion, 41(5), p.645 - 651, 2001/05

 Times Cited Count:55 Percentile:84.47(Physics, Fluids & Plasmas)

no abstracts in English

Journal Articles

Simple internal exposure measurement for tritium by expiratory water trapping method using water bubbler

Tsujimoto, Takayuki; Nishizono, Tatsuya; Tamura, Katsuhiro

Proceedings of 10th International Congress of the International Radiation Protection Association (IRPA-10) (CD-ROM), 5 Pages, 2000/05

no abstracts in English

Journal Articles

Intercomparison of measurements and questionnaire on the distribution coefficient

Takahashi, Tomoyuki*; Takebe, Shinichi; Kimura, Hideo; Matsuzuru, Hideo; Yasuda, Hiroshi*; Uchida, Shigeo*; Saeki, Akiyoshi*; Mahara, Yasunori*; Sasaki, Noriyuki*; Ashikawa, Nobuo*; et al.

KURRI-KR-44, p.169 - 176, 2000/02

no abstracts in English

Oral presentation

Analysis of radiation-induced cell death in vivo by in-air micro-PIXE

Hasegawa, Masatoshi*; Sakurai, Hideyuki*; Shin, Masako*; Okamoto, Masahiko*; Ishiuchi, Shogo*; Asakawa, Isao*; Tamamoto, Tetsuo*; Ono, Tatsuya*; Oikawa, Masakazu*; Kamiya, Tomihiro; et al.

no journal, , 

no abstracts in English

29 (Records 1-20 displayed on this page)