Fukui, Roman*; Saga, Ryo*; Matsuya, Yusuke; Tomita, Kazuo*; Kuwahara, Yoshikazu*; Ouchi, Kentaro*; Sato, Tomoaki*; Okumura, Kazuhiko*; Date, Hiroyuki*; Fukumoto, Manabu*; et al.
Scientific Reports (Internet), 12(1), p.1056_1 - 1056_12, 2022/01
Alive cancer cells after fractionated irradiations with 2 Gy X-rays per day for more than 30 days show clinically relevant radioresistant. Such radioresistance is experimentally interpreted to attributed to the increment of stem-like cell content. However, only an experimental approach cannot clarify the cell responses (DNA damage and cell death induction) of cancer stem cells, so the radioresistant mechanisms remain uncertain. In addition to the conventional cell experiments using radio-resistant cell lines established after fractionated irradiations, in this study we developed a mathematical model (so called integrated microdosimetric-kinetic (IMK) model) explicitly considering cancer stem-like cell content and DNA damage responses and investigated radioresistant mechanisms acquired after fractionated irradiations. The IMK model analysis suggested that the changes of stem-like cell fraction and DNA repair efficiency play important roles of radioresisitance acquired after irradiations. Considering these into the IMK model, we successfully reproduced the experimental survival of various cell lines and various irradiation conditions. This work would contribute to not only the precise understanding of the radioresistant mechanisms induced after irradiation but also predicting curative effects with high precision.
Kato, Masaji*; Nara, Yoshitaka*; Okazaki, Yuki*; Kono, Masanori*; Sato, Toshinori; Sato, Tsutomu*; Takahashi, Manabu*
Materials Transactions, 59(9), p.1427 - 1432, 2018/09
To ensure the safe geological disposal of radioactive waste, it is important to determine the permeability (hydraulic conductivity) of clays. The transient pulse method is suitable for low-permeability materials because it requires a relatively short time to determine their permeability. Upstream pore pressure typically increases in the measurement conducted via the transient pulse method. However, this procedure cannot be used to determine the permeability of clays due to the increase in pore pressure. Therefore, the transient pulse method has never been applied to determine clay permeability. In this study, we applied the transient pulse method to a clay sample to determine its permeability while decreasing the downstream pore pressure.
Nara, Yoshitaka*; Kato, Masaji*; Niri, Ryuhei*; Kono, Masanori*; Sato, Toshinori; Fukuda, Daisuke*; Sato, Tsutomu*; Takahashi, Manabu*
Pure and Applied Geophysics, 175(3), p.917 - 927, 2018/03
Information on the permeability of rock is essential for various geoengineering projects. It is especially important to investigate how fractures and pores influence the physical and transport properties of rock. Infiltration of groundwater through the damage zone fills fractures in granite with fine-grained minerals. However, the permeability of rock possessing a fracture naturally filled with fine-grained mineral grains has yet to be investigated. In this study, the permeabilities of granite samples, including a macro-fracture filled with clay and a mineral vein, are investigated. The permeability of granite with a fine-grained mineral vein agrees well with that of the intact sample, whereas the permeability of granite possessing a macro-fracture filled with clay is lower than that of the macro-fractured sample. The decrease in the permeability is due to the filling of fine-grained minerals and clay in the macro-fracture. It is concluded that the permeability of granite increases due to the existence of the fractures, but decreases upon filling them with fine-grained minerals.
Kato, Masaji*; Nara, Yoshitaka*; Okazaki, Yuki*; Kono, Masanori*; Sato, Toshinori; Sato, Tsutomu*; Takahashi, Manabu*
Zairyo, 67(3), p.318 - 323, 2018/03
To ensure the safe geological disposal of radioactive wastes, it is important to determine the permeability of clays. The transient pulse test is suitable to apply to the low permeability materials, because it takes relatively short term to determine the permeability. Usually we increase the upstream pore pressure in the measurement with the transient pulse test. However, it is impossible to determine the permeability of clay in this procedure because of the increase of pore pressure. Therefore, the transient pulse test has never been applied to the determination of permeability of clays. In this study, we tried to apply the transient pulse test to a clay obtained in Mizunami Underground Research Laboratory to determine the permeability with decreasing the downstream pore pressure. It was clarified that the transient pulse test with decreasing downstream pore pressure is appropriate from the measurements of granite and sandstone. It was shown that the permeability of a clay was determined by the transient pulse test with decreasing the downstream pore pressure, which agreed with the permeability determined from the falling head test. The measurement time of the transient pulse test is much shorter than that of the falling head test. It is concluded that the transient pulse test is appropriate for the determination of the permeability of clays.
Kato, Masaji*; Nara, Yoshitaka*; Fukuda, Daisuke*; Kono, Masanori*; Sato, Toshinori; Sato, Tsutomu*; Takahashi, Manabu*
Zairyo, 65(7), p.489 - 495, 2016/07
Rock masses serve a vital function as natural barriers for geological disposal of radioactive waste; therefore, information on rock permeability is essential. Highly accurate measurement of permeability requires understanding of how temperature changes in the surrounding environment influence measurement results. We performed permeability measurement under conditions with dramatic changes of temperature in the surrounding environment to investigate the influence of such changes on the experimental results. Measurement of permeability with no temperature change was also conducted as reference. All measurements were conducted using the transient pulse method, and the sample material used was Toki granite obtained from Gifu Prefecture in central Japan. We found that temperature changes in the surrounding environment remarkably affected the pressure in reservoirs upstream and downstream, the pressure difference between them, and the confining pressure; all increased when temperature increased for our experimental system. Notably, pressure difference was affected immediately. This difference directly relates to estimation of permeability.
Wakai, Takashi; Machida, Hideo*; Arakawa, Manabu*; Sato, Kenichiro*
Nihon Kikai Gakkai 2015-Nendo Nenji Taikai Koen Rombunshu (DVD-ROM), 5 Pages, 2015/09
This paper describes a J-integral evaluation procedure applicable to unstable failure analysis for a circumferential through wall crack in a pipe. Japan Sodium cooled Fast Reactor (JSFR) pipes are made of Mod.9Cr-1Mo steel. The fracture toughness of the material is inferior to that of conventional austenitic stainless steels. In addition, JSFR pipe has small thickness and large diameter and displacement controlled load is predominant. Therefore, the load balance in such piping system changes by crack extension and 2 parameter method using J-integral is applicable to unstable failure analysis for the pipes under such conditions. As a J-integral evaluation method for circumferential through wall crack in a cylinder, EPRI has proposed a fully plastic solution method. However, the geometry of JSFR pipe and material characteristics of Mod.9Cr-1Mo steel exceed the applicable range of EPRI's method. Therefore, a series of elastic, elastoplastic and plastic finite element analyses (FEA) were performed for a pipe with a circumferential through-wall crack to establish a J-integral evaluation method applicable to such conditions. J-integrals obtained from the FEA were resolved into elastic, local plastic and fully plastic components. Each component was expressed as a function of analytical parameter, such as pipe geometries, crack size, material characteristics and so on. As a result, a simplified J-integral evaluation method was proposed.
Sakaki, Hironao; Nishiuchi, Mamiko; Maeda, Shota; Sagisaka, Akito; Pirozhkov, A. S.; Pikuz, T.; Faenov, A.*; Ogura, Koichi; Fukami, Tomoyo; Matsukawa, Kenya*; et al.
Review of Scientific Instruments, 85(2), p.02A705_1 - 02A705_4, 2014/02
High intensity laser-plasma interaction has attracted considerable interest for a number of years. The laser-plasma interaction is accompanied by generation of various charged particle beams. Results of simultaneous novel measurements of electron-induced photonuclear neutrons (photoneutron), which are a diagnostic of the laser-plasma interaction, are proposed to use for optimization of the laser-plasma ion generation. The proposed method is demonstrated by the laser irradiation with the intensity os 110 W/cm on the metal foil target. The photoneutrons are measured by using NE213 liquid scintillation detectors. Heavy-ion signal is registered with the CR39 track detector simultaneously. The measured signals of the electron-induced photoneutrons are well reproduced by using the Particle and Heavy Ion Transport code System (PHITS). The results obtained provide useful approach for analyzing the various laser based ion beams.
Teshigawara, Makoto; Kinoshita, Hidetaka; Wakui, Takashi; Meigo, Shinichiro; Seki, Masakazu; Harada, Masahide; Ito, Manabu; Suzuki, Toru; Ikezaki, Kiyomi; Maekawa, Fujio; et al.
JAEA-Technology 2012-024, 303 Pages, 2012/07
3 GeV Protons with 1 MW beam power are irradiated to mercury target of spallation neutron source in Materials and Life science Facility (MLF), which is one of facilities of J-PARC. Irradiated components, such as target container, moderator, reflector and proton beam window, are needed to replace periodically due to irradiation damage of high energy protons and neutrons. These used components are replaced remotely because of highly activated. Maintenance scenario was settled so as to handle these components. Required remote handling machines were designed and installed in hot cell and other room of the MLF. We performed remote handling tests by using actual components to confirm the design. We report results, such as replacement procedure, trouble and its solution, etc., for moderator, reflector and proton beam window in order to provide the handling of actual used components.
Kimura, Hideo; Aoyagi, Tetsuo; Sato, Taiichi; Sakai, Manabu; Hikasa, Naoki*; Suzuki, Hitoshi; Tsuji, Minoru
JAEA-Technology 2011-027, 31 Pages, 2011/09
The financial accounting and contract management system of JAEA, built on a commercial ERP package, had suffered from serious problems of high lifecycle cost, poor response, and lack of extensibility, due to the too much customization to the ERP package, and disorganized software structure. To solve those problems, three approaches were applied; (1) conducting thorough analysis of business flow and fit/gap, which enabled removing all customization brought to the ERP package; (2) dividing the system into subsystems, and clearly defining interfaces between the subsystems, which increases the transparency, extensibility and performance of the system; (3) outsourcing the development of the subsystems to multiple venders to reduce the development cost. Those approaches can be useful for developing business information systems using commercial software to save time and cost, while meeting the unique requirements of an organization.
Adare, A.*; Afanasiev, S.*; Aidala, C.*; Ajitanand, N. N.*; Akiba, Yasuyuki*; Al-Bataineh, H.*; Alexander, J.*; Aoki, Kazuya*; Aphecetche, L.*; Armendariz, R.*; et al.
Physical Review C, 83(6), p.064903_1 - 064903_29, 2011/06
Transverse momentum distributions and yields for , and in collisions at = 200 and 62.4 GeV at midrapidity are measured by the PHENIX experiment at the RHIC. We present the inverse slope parameter, mean transverse momentum, and yield per unit rapidity at each energy, and compare them to other measurements at different collisions. We also present the scaling properties such as and scaling and discuss the mechanism of the particle production in collisions. The measured spectra are compared to next-to-leading order perturbative QCD calculations.
Adare, A.*; Afanasiev, S.*; Aidala, C.*; Ajitanand, N. N.*; Akiba, Yasuyuki*; Al-Bataineh, H.*; Alexander, J.*; Aoki, Kazuya*; Aphecetche, L.*; Aramaki, Y.*; et al.
Physical Review C, 83(4), p.044912_1 - 044912_16, 2011/04
Measurements of electrons from the decay of open-heavy-flavor mesons have shown that the yields are suppressed in Au+Au collisions compared to expectations from binary-scaled collisions. Here we extend these studies to two particle correlations where one particle is an electron from the decay of a heavy flavor meson and the other is a charged hadron from either the decay of the heavy meson or from jet fragmentation. These measurements provide more detailed information about the interaction between heavy quarks and the quark-gluon matter. We find the away-side-jet shape and yield to be modified in Au+Au collisions compared to collisions.
Tobita, Kenji; Nishio, Satoshi*; Enoeda, Mikio; Nakamura, Hirofumi; Hayashi, Takumi; Asakura, Nobuyuki; Uto, Hiroyasu; Tanigawa, Hiroyasu; Nishitani, Takeo; Isono, Takaaki; et al.
JAEA-Research 2010-019, 194 Pages, 2010/08
This report describes the results of the conceptual design study of the SlimCS fusion DEMO reactor aiming at demonstrating fusion power production in a plant scale and allowing to assess the economic prospects of a fusion power plant. The design study has focused on a compact and low aspect ratio tokamak reactor concept with a reduced-sized central solenoid, which is novel compared with previous tokamak reactor concept such as SSTR (Steady State Tokamak Reactor). The reactor has the main parameters of a major radius of 5.5 m, aspect ratio of 2.6, elongation of 2.0, normalized beta of 4.3, fusion out put of 2.95 GW and average neutron wall load of 3 MW/m. This report covers various aspects of design study including systemic design, physics design, torus configuration, blanket, superconducting magnet, maintenance and building, which were carried out increase the engineering feasibility of the concept.
Iwatsuki, Teruki; Sato, Haruo; Tanai, Kenji; Inagaki, Manabu; Sawada, Atsushi; Niinuma, Hiroaki; Ishii, Eiichi; Maekawa, Keisuke; Tomura, Goji; Sanada, Hiroyuki; et al.
JAEA-Research 2009-002, 156 Pages, 2009/05
The research and development plan for geological investigation, engineering technology and safety assessment during the drilling of a shaft down to intermediate depth are summarized according to the Midterm Plan till 2009 Fiscal year of JAEA. This report describes subject, current status and programme in the "Phase 2: Construction phase" (investigations during construction of the underground facilities). Furthermore regarding R&D plan in next Midterm Plan of JAEA, preliminary ideas are summarized.
Yogo, Akifumi; Sato, Katsutoshi; Nishikino, Masaharu; Mori, Michiaki; Teshima, Teruki*; Numasaki, Hodaka*; Murakami, Masao*; Demizu, Yusuke*; Akagi, Takashi*; Nagayama, Shinichi*; et al.
Applied Physics Letters, 94(18), p.181502_1 - 181502_3, 2009/05
Kimura, Hideo; Aoyagi, Tetsuo; Sakai, Manabu; Sato, Taiichi; Tsuji, Minoru
JAEA-Technology 2008-075, 32 Pages, 2008/11
JAEA developed the ERP (Enterprise Resource Planning) system at the establishment in 2005, aiming to support and enhance its business-critical task such as financial accounting and contract management. We considered the conceptual design of the next ERP system, and we implemented the prototype system to validate its effectiveness. Moreover, we implemented the simple add-on tool for rapid and easy development. At the result, we gauged the future prospects that the XML-centric system which we designed will offer high modularity, flexibility, connectivity between other systems, independence among subsystems. The simple add-on tool also demonstrated its effectiveness.
Kawamata, Yoichi; Naito, Osamu; Kiyono, Kimihiro; Itami, Kiyoshi; Totsuka, Toshiyuki; Akasaka, Hiromi; Sueoka, Michiharu; Sato, Tomoki; Oshima, Takayuki; Sakata, Shinya; et al.
Fusion Engineering and Design, 83(2-3), p.198 - 201, 2008/04
The design activity of JT-60SA (JT-60 Super Advanced) which is remodeled to a superconducting tokamak device has been starting under the JA-EU collaborative ITER-BA project. For the JT-60SA control system, the existing system should be reused as much as possible from the viewpoint of cost-effectiveness. We have just begun to discuss the configuration of the advanced Supervisory Control System (SVCS) including the following systems: (1) ultimately flexible real-time control system, (2) precise timing system enough to clarify cause and effect, and (3) safety shutdown control system. In this report, we present the design study of the JT-60SA SVCS with focusing on these systems.
Hender, T. C.*; Wesley, J. C.*; Bialek, J.*; Bondeson, A.*; Boozer, A. H.*; Buttery, R. J.*; Garofalo, A.*; Goodman, T. P.*; Granetz, R. S.*; Gribov, Y.*; et al.
Nuclear Fusion, 47(6), p.S128 - S202, 2007/06
no abstracts in English
Ninomiya, Hiromasa; Akiba, Masato; Fujii, Tsuneyuki; Fujita, Takaaki; Fujiwara, Masami*; Hamamatsu, Kiyotaka; Hayashi, Nobuhiko; Hosogane, Nobuyuki; Ikeda, Yoshitaka; Inoue, Nobuyuki; et al.
Journal of the Korean Physical Society, 49, p.S428 - S432, 2006/12
To contribute DEMO and ITER, the design to modify the present JT-60U into superconducting coil machine, named National Centralized Tokamak (NCT), is being progressed under nationwide collaborations in Japan. Mission, design and strategy of this NCT program is summarized.
Tsuzuki, Kazuhiro; Kamiya, Kensaku; Shinohara, Koji; Bakhtiari, M.*; Ogawa, Hiroaki; Kurita, Genichi; Takechi, Manabu; Kasai, Satoshi; Sato, Masayasu; Kawashima, Hisato; et al.
Nuclear Fusion, 46(11), p.966 - 971, 2006/11
no abstracts in English
Kikuchi, Mitsuru; Tamai, Hiroshi; Matsukawa, Makoto; Fujita, Takaaki; Takase, Yuichi*; Sakurai, Shinji; Kizu, Kaname; Tsuchiya, Katsuhiko; Kurita, Genichi; Morioka, Atsuhiko; et al.
Nuclear Fusion, 46(3), p.S29 - S38, 2006/03
The National Centralized Tokamak (NCT) facility program is a domestic research program for advanced tokamak research to succeed JT-60U incorporating Japanese university accomplishments. The mission of NCT is to establish high beta steady-state operation for DEMO and to contribute to ITER. The machine flexibility and mobility is pursued in aspect ratio and shape controllability, feedback control of resistive wall modes, wide current and pressure profile control capability for the demonstration of the high-b steady state.