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Hirose, Akira; Komeda, Masao; Kinase, Masami; Sorita, Takami; Wada, Shigeru
JAEA-Technology 2010-007, 68 Pages, 2010/06
We investigated the production process of Mo, which is parent nuclide of
Tc, in JRR-3.
Tc is most commonly used as a radiopharmaceutical in the field of nuclear medicine. Currently the supplying of
Mo is only dependent on imports from foreign countries, so JAEA is aiming at domestic production of a part of
Mo in cooperation with the industrial arena. This report presents the technical study for the production process of
Mo by using the neutron radiation method of (n,
) reaction in JRR-3.
Kogure, Hiroto; Sorita, Takami; Iwamoto, Seikichi; Nagata, Yasushi*; Hiraoka, Masahiro*; Iwata, Kazuro*; Kawauchi, Yukimasa*; Suzuki, Kazutoshi*
JAERI-Tech 2003-003, 26 Pages, 2003/03
Intravascular brachytherapy is a novel therapy for preventing the restenosis of coronary artery by use of low-dose irradiation. JAERI and Kyoto University have been developing Ir radiation sources by the cooperative research project entitled as "The research on safety and effectiveness of the intravascular brachytherapy for preventing restenosis of the coronary artery disease" since 1998. The radiation source was introduced into the stenosis through a catheter (a guide-tube to insert directly into vascular) to irradiate the diseased part. Ten
Ir seed sources (
0.4 mm
2.5 mm) were positioned between nylon spacers (
0.3 mm
1.0 mm) in a flexible covering tube and the tube was plugged with a core-wire; the tube was shrunk to fix the inside materials and the size is 0.46 mm in diameter and 3 m in length. The physically optimal design was determined to insert the radiation source easily into vascular and to get the dose uniformity in the diseased part. The production method of the radiation source, which is practical to use in the clinics was also established.
Sekine, Toshiaki; Izumo, Mishiroku; Matsuoka, Hiromitsu; Kobayashi, Katsutoshi; Ishioka, Noriko; Osa, Akihiko; Koizumi, Mitsuo; Motoishi, Shoji; Hashimoto, Kazuyuki; ; et al.
Proc. of the 5th Int. Workshop on Targetry and Target Chemistry, 0, p.347 - 352, 1994/00
no abstracts in English
Izumo, Mishiroku; Matsuoka, Hiromitsu; Sorita, Takami; Nagame, Yuichiro; Sekine, Toshiaki; ;
Applied Radiation and Isotopes, 42(3), p.297 - 301, 1991/00
no abstracts in English
Izumo, Mishiroku; Sorita, Takami; Matsuoka, Hiromitsu; Nagame, Yuichiro; ; Sekine, Toshiaki;
JAERI-M 90-156, 13 Pages, 1990/09
no abstracts in English
Izumo, Mishiroku; Sorita, Takami; ; Sekine, Toshiaki; Matsuoka, Hiromitsu; Motoki, Ryozo;
JAERI-M 90-102, 28 Pages, 1990/07
no abstracts in English
Hirose, Akira; Komeda, Masao; Kinase, Masami; Sorita, Takami; Sagawa, Hisashi; Wada, Shigeru
no journal, ,
no abstracts in English
Hashimoto, Kazuyuki; Motoishi, Shoji; Saeki, Hideya*; Sorita, Takami; Matsuoka, Hiromitsu
no journal, ,
no abstracts in English
Hashimoto, Kazuyuki; Motoishi, Shoji*; Saeki, Hideya*; Sorita, Takami; Matsuoka, Hiromitsu
no journal, ,
Rhenium-188 is a useful generator-produced radioisotope for therapeutic applications because of their energetic beta particles and rays suitable for imaging. Because the
W parent is obtained in a relatively low specific activity from the irradiation of enriched
W in a reactor, relatively large volumes of normal saline are required to elute the
Re from alumina based
W/
Re generators. In this study, a simple apparatus for effective concentrations of 188Re solutions from alumina-based
W/
Re generators was developed by a tandem cation-anion column system. Concentration ratios greater than 50:1 can be achieved with this apparatus.
Komeda, Masao; Hirose, Akira; Sorita, Takami; Wada, Shigeru; Ishikawa, Koji*
no journal, ,
no abstracts in English
Komoto, Kazuki*; Nogawa, Norio*; Sato, Jun*; Makide, Yoshihiro*; Morikawa, Naotake*; Hashimoto, Kazuyuki; Sorita, Takami
no journal, ,
Complex compound of Re and
Re with meso-2,3-dimercaptosuccinic acid (DMSA) is expected to be effective against cancerous disease. This compound is synthesized with high radiochemical yield by use of SnCl
as reducing reagent. However, the product contains a large amount of SnCl
which is harmful to human body. The removal of tin impurity was tested with cation exchange resin.
Re-DMSA complex was also obtained with high radiochemical yield by use of other harmless reducing agents (L-ascorbic acid, Na
SO
, H
PO
). Synthesized
Re-DMSA by use of SnCl
was stable in sodium acetate buffer for 5 hours, while survival amount of
Re-DMSA synthesized by other reducing agents decreased in a short time.