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Journal Articles

Application of $$^{67}$$Cu produced by $$^{68}$$Zn($$n,n'p+d$$)$$^{67}$$Cu to biodistribution study in tumor-bearing mice

Sugo, Yumi*; Hashimoto, Kazuyuki*; Kawabata, Masako*; Saeki, Hideya*; Sato, Shunichi*; Tsukada, Kazuaki; Nagai, Yasuki*

Journal of the Physical Society of Japan, 86(2), p.023201_1 - 023201_3, 2017/02

 Times Cited Count:12 Percentile:73.29(Physics, Multidisciplinary)

$$^{67}$$Cu produced by the $$^{68}$$Zn($$n,n'p+d$$)$$^{67}$$Cu reaction was used for the first time to determine the biodistribution of $$^{67}$$CuCl$$_{2}$$ in colorectal tumor-bearing mice. High uptake of $$^{67}$$Cu was observed in the tumor as well as in the liver and kidney which are the major organs for copper metabolism. The result showing $$^{67}$$Cu accumulation in the tumor suggests that $$^{67}$$CuCl$$_{2}$$ can be a potential radionuclide agent for cancer radiotherapy. It would also encourage further studies on the therapeutic effect in small animals using an increased dose of $$^{67}$$Cu produced by the $$^{68}$$Zn($$n,n'p+d$$)$$^{67}$$Cu reaction using intense neutrons available at present.

Journal Articles

Medical application of radiohalogenated peptides; Synthesis and ${it in vitro}$ evaluation of F(${it p}$-$$^{131}$$I)KCCYSL for targeting HER2

Sasaki, Ichiro; Watanabe, Shigeki; Ohshima, Yasuhiro; Sugo, Yumi; Yamada, Keiichi*; Hanaoka, Hirofumi*; Ishioka, Noriko

Peptide Science 2015, p.243 - 246, 2016/03

Journal Articles

Simultaneous analysis of silicon and boron dissolved in water by combination of electrodialytic salt removal and ion-exclusion chromatography with corona charged aerosol detection

Mori, Masanobu*; Sagara, Katsuya*; Arai, Kaori*; Nakatani, Nobutake*; Ohira, Shinichi*; Toda, Kei*; Itabashi, Hideyuki*; Kozaki, Daisuke*; Sugo, Yumi; Watanabe, Shigeki; et al.

Journal of Chromatography A, 1431, p.131 - 137, 2016/01

 Times Cited Count:8 Percentile:44.25(Biochemical Research Methods)

Journal Articles

The Effect of alkyl substituents on actinide and lanthanide extraction by diglycolamide compounds

Sasaki, Yuji; Sugo, Yumi; Morita, Keisuke; Nash, K.*; Nash, K. L.*

Solvent Extraction and Ion Exchange, 33(7), p.625 - 641, 2015/10

 Times Cited Count:64 Percentile:88.97(Chemistry, Multidisciplinary)

The effect of alkyl substituents at amidic N atoms in diglycolamide (DGA) compounds on solvent extraction was investigated. The solubility in water and n-dodecane, loading capacity, and distribution ratio (D) of lanthanides and actinides for various DGA compounds were monitored. DGA derivatives with short alkyl chains, for example methyl and ethyl groups, are highly water soluble, while DGA derivatives with long alkyl chains are highly soluble in n-dodecane. The loading capacity correlats with their alkyl chain lengths. The results of masking effect and solubility tests indicate that TEDGA(tetraethyl-diglycolamide) is the best actinide masking agent among the water-soluble DGA derivatives. Actinide extractions were performed using ten DGA compounds in six diluents (nitrobenzene, 1,2-dichloroethane, 1-octanol, chloroform, toluene, and n-dodecane), in which it was observed that DGA derivatives with shorter alkyl chains show higher D values.

Journal Articles

Studies on the extraction of soft acid metal species using MIDOA and analogous compounds

Sasaki, Yuji; Saeki, Morihisa; Sugo, Yumi; Ikeda, Yasuhisa*; Kawasaki, Takeshi*; Suzuki, Tomoya*; Ohashi, Akira*

Solvent Extraction Research and Development, Japan, 22(1), p.37 - 45, 2015/05

 Times Cited Count:9 Percentile:37.92(Chemistry, Multidisciplinary)

An extractant, methylimino-bis-${it N,N'}$-dioctylacetamide (MIDOA), was used for the extraction of soft acid metals. It was found that MIDOA can extract not only Cr(VI), Mo(VI), W(VI), Tc(VII) and Re(VII), whose metals can form the oxonium anions due to their high oxidation states, but also other metal cations, like Nb(V), Ta(V) and Pd(II). Analogous compounds, imino-bis-${it N,N'}$-dioctylacetamide (IDOA) and methylimino-bis-${it N,N'}$-di-2-ethylhexylacetamide (MIDEHA), are synthesized and compared for their extractability. It is clear that these extractants have almost same or lower $$D$$ values than those for MIDOA. In order to examine the effect on extractability with different donor atoms, TODGA (${it N,N,N',N'}$-tetraoctyl-diglycolamide) and TDGA (${it N,N,N',N'}$-tetraoctyl-tyiodiglycolamide) having oxygen and sulfur donor are employed. The comparison of their extractabilities suggests that the trend of Pd and Re extraction is N $$>$$ S $$>$$ O and N $$>$$ O $$>$$ S, respectively.

Journal Articles

Synthesis and ${{it in vitro}}$ evaluation of $$^{64}$$Cu-labeled peptide for tumor imaging

Sugo, Yumi; Sasaki, Ichiro; Watanabe, Shigeki; Ohshima, Yasuhiro; Ishioka, Noriko

JAEA-Review 2014-050, JAEA Takasaki Annual Report 2013, P. 100, 2015/03

Journal Articles

${{it In vitro}}$ studies on cellular binding and stability of $$^{64}$$Cu-labeled peptide for tumor imaging

Sugo, Yumi; Ohshima, Yasuhiro; Sasaki, Ichiro; Ishioka, Noriko

Peptide Science 2014, p.303 - 306, 2015/03

Journal Articles

Exploring of peptides with affinity to HER2 from random peptide libraries using radioisotope; Random hexapeptide libraries with fixed amino acid sequence at 1 and 2 positions

Sasaki, Ichiro; Hanaoka, Hirofumi*; Yamada, Keiichi*; Watanabe, Shigeki; Sugo, Yumi; Ohshima, Yasuhiro; Suzuki, Hiroyuki; Ishioka, Noriko

Peptide Science 2014, p.257 - 260, 2015/03

Journal Articles

$$alpha$$-radiation effect on solvent extraction of minor actinide

Sugo, Yumi; Sasaki, Yuji; Taguchi, Mitsumasa; Ishioka, Noriko

Journal of Radioanalytical and Nuclear Chemistry, 303(2), p.1381 - 1384, 2015/02

 Times Cited Count:1 Percentile:12.03(Chemistry, Analytical)

Journal Articles

Effect of the central frames and substituents attached to N atoms on extraction ability of podand-type extractants

Sasaki, Yuji; Kitatsuji, Yoshihiro; Sugo, Yumi; Tsubata, Yasuhiro; Suzuki, Tomoya; Kimura, Takaumi; Morita, Yasuji

Proceedings of 20th International Solvent Extraction Conference (ISEC 2014), p.431 - 435, 2014/09

The eight amide extractants including podand-types, which introduce oxygen, nitrogen and sulfur donor atoms in their central frame, are synthesized and their D values for actinide extraction are compared. The central frame affect greatly on their extractability and it is clear that diglycolamide (DGA) has the highest extractability among extractants used here. In addition, DGA having the different length of alkyl chain or phenyl groups attached to amidic N atoms are obtained and the effect of these substituents is studied. Due to the steric hindrance or hydrogen bond, DGA with long and branched alkyl chains, phenyl group, and proton give relatively low D values.

JAEA Reports

"Development of mutual separation technology of minor actinides by the novel hydrophilic and lipophilic diamide compounds" summary of the researches for three years (Contract research)

Sasaki, Yuji; Tsubata, Yasuhiro; Kitatsuji, Yoshihiro; Sugo, Yumi; Shirasu, Noriko; Ikeda, Yasuhisa*; Kawasaki, Takeshi*; Suzuki, Tomoya*; Mimura, Hitoshi*; Usuda, Shigekazu*; et al.

JAEA-Research 2014-008, 220 Pages, 2014/06


The researches on Development of mutual separation technology of minor actinides by the novel hydrophilic and lipophilic diamide compounds, entrusted to Japan Atomic Energy Agency by the Ministry of Education, Culture, Sports, Science and Technology of Japan, from 2010 to 2012 are summarized. This project was composed of three themes, those are (1) Development of total recovery of MA+Ln: basic researches for new extractant, DOODA, (2) Development of mutual separation of Am/Cm/Ln: basic researches of Ln-complex, solvent extraction, and extraction chromatography, and (3) Evaluation of separation technique: process simulation. For topic (1), we summarized the information on characteristic of DOODA extractant. For topic (2), we summarized the information on structures of Ln-complexes, solvent extraction and chromatography. For topic (3), we summarized the information on conditions of mixer-settler and evaluation of each fraction separated.

Journal Articles

Development of extraction chromatographic adsorbent using alkylpyridinedicarboxyamides as extractant for separation of trivalent minor actinides from lanthanides; Stability and separation ability against nitric acid exposure and $$gamma$$-ray irradiation

Arisaka, Makoto; Watanabe, Masayuki; Sugo, Yumi; Kobayashi, Kumiko*; Kanao, Osamu*; Kimura, Takaumi

Journal of Nuclear Science and Technology, 51(4), p.457 - 464, 2014/04

 Times Cited Count:1 Percentile:10.7(Nuclear Science & Technology)

Toward the development of a practical separation method for trivalent actinides and lanthanides, we used extraction chromatography with alkyl-pyridinedicarboxyamides as the extractant. The results confirmed that the performance degradation of the adsorbent caused by contact with HNO$$_{3}$$ and/or irradiation with $$gamma$$ rays would be very small during the operation of column chromatography. The optimal conditions for the column separation were also determined: eluent, 5M HNO$$_{3}$$; flow rate, 0.1 mL/min.

Journal Articles

Radiolytic stabilities of hydrophilic and lipophilic ligands for mutual separation of Am/Cm/Ln

Sugo, Yumi; Sasaki, Yuji; Ishioka, Noriko

JAEA-Review 2013-059, JAEA Takasaki Annual Report 2012, P. 17, 2014/03

Journal Articles

Synthesis of radiohalogen-labeled peptide with high affinity to HER2/neu receptor

Sasaki, Ichiro; Yamada, Keiichi*; Watanabe, Shigeki; Hanaoka, Hirofumi*; Sugo, Yumi; Oku, Hiroyuki*; Ishioka, Noriko

JAEA-Review 2013-059, JAEA Takasaki Annual Report 2012, P. 96, 2014/03

Journal Articles

Synthesis and ${it in vitro}$ Evaluation of $$^{64}$$Cu-labeled peptide for tumor imaging

Sugo, Yumi; Sasaki, Ichiro; Watanabe, Shigeki; Ohshima, Yasuhiro; Ishioka, Noriko

Peptide Science 2013, p.355 - 358, 2014/03

Journal Articles

Mutual separation of Am/Cm/Ln by the use of novel-triamide, NTAamide and water-soluble diglycolamide

Sasaki, Yuji; Tsubata, Yasuhiro; Kitatsuji, Yoshihiro; Sugo, Yumi; Shirasu, Noriko; Morita, Yasuji

Proceedings of International Nuclear Fuel Cycle Conference; Nuclear Energy at a Crossroads (GLOBAL 2013) (CD-ROM), p.1079 - 1082, 2013/09

Mutual separation of Am, Cm and lanthanides (Ln) is important to develop the partitioning process of high-level radioactive liquid waste, because the application to their different disposal methods are advantageous. Namely, Am is studied for transmutation due to the reduction of long half-life radionuclides, Cm should be kept in interim storage in order to reduce the calorific value, and Ln should be present in the vitrified radioactive waste toward the geological disposal. However, this mutual separation method is difficult to establish because they have very similar chemical behavior, same oxidation state (III) and similar ionic radii. The development of their mutual separation is termed as the challenging study. In order to obtain the satisfactory results, the property of extractant requires the differentiation of actinide (An) from Ln, high preferability to different ionic radii between Am and Cm, and high extractability to hard acids. Therefore, the extractant have to include both N atom, whose soft donor has high selectivity between An and Ln, and O atoms for the strong extractability to An. The new extractant, NTAamide (N,N,N',N',N'',N''-hexaoctyl-nitrirotriacetamide) is a triamide having N donor at the center of backbone, then NTAamide has hybrid performance of complexation to metals by soft N and three hard amidic O atoms. It is clear that NTAamide can extract trivalent An at diluted HNO$$_{3}$$ with small D(Ln), the separation of An from Ln can be carried out at that condition. The SF of Am/Cm by NTAamide is approximate 1.8, which is not so high to separate each other. The combination of NTAamide of extractant and TEDGA (N,N,N',N'-tetraethyl-diglycolamide) as a masking agent in the aqueous phase shows very high SF(Am/Cm) of maximal 6.5. It is obvious that NTAamide is a promising extractant to achieve the mutual separation among Am/Cm/Ln.

Journal Articles

Synthesis of radiohalogen-labeled peptides with high affinity to HER2/neu receptor

Sasaki, Ichiro; Yamada, Keiichi*; Watanabe, Shigeki; Hanaoka, Hirofumi*; Sugo, Yumi; Oku, Hiroyuki*; Ishioka, Noriko

Peptide Science 2013, p.157 - 160, 2013/03

Journal Articles

Radiation effect on solvent extraction of minor actinide

Sugo, Yumi; Taguchi, Mitsumasa; Sasaki, Yuji; Morita, Yasuji; Ishioka, Noriko

JAEA-Review 2012-046, JAEA Takasaki Annual Report 2011, P. 18, 2013/01

Journal Articles

Preparation and biological evaluation of 3-[$$^{76}$$Br]bromo-$$alpha$$-methyl-L-tyrosine, a novel tyrosine analog for PET imaging of tumors

Ohshima, Yasuhiro; Hanaoka, Hirofumi*; Watanabe, Shigeki; Sugo, Yumi; Watanabe, Satoshi; Tominaga, Hideyuki*; Oriuchi, Noboru*; Endo, Keigo*; Ishioka, Noriko

JAEA-Review 2011-043, JAEA Takasaki Annual Report 2010, P. 91, 2012/01

Journal Articles

Influence of energy of helium ions on degradation of diglycolamide in ${it n}$-dodecane

Sugo, Yumi; Taguchi, Mitsumasa; Sasaki, Yuji; Morita, Yasuji

JAEA-Review 2011-043, JAEA Takasaki Annual Report 2010, P. 18, 2012/01

137 (Records 1-20 displayed on this page)