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Journal Articles

Maintaining formation of multiple robotic wheelchairs for smooth communication

Suzuki, Ryota*; Kobayashi, Yoshinori*; Kuno, Yoshinori*; Yamada, Taichi; Yamazaki, Keiichi*; Yamazaki, Akiko*

International Journal on Artificial Intelligence Tools, 25(5), p.1640005_1 - 1640005_19, 2016/10

 Times Cited Count:1 Percentile:12.53(Computer Science, Artificial Intelligence)

To meet the demands of an aging society, research on intelligent/robotic wheelchairs have been receiving a lot of attention. In elderly care facilities, care workers are required to communicate with the elderly in order to maintain both their mental and physical health. While this is regarded as important, having a conversation with someone on a wheelchair while pushing it from behind in a traditional setting would interfere with their smooth and natural conversation. So we are developing a robotic wheelchair system which allows companions and wheelchair users to move in a natural formation. This paper reports on an investigation to learn the patterns of human behavior when the wheelchair users and their companions communicate while walking together. The ethnographic observation reveals a natural formation of positioning for both companions and wheelchair users. Based on this investigation, we propose a multiple robotic wheelchair system which can maintain desirable formations for communication between wheelchairs.

Journal Articles

Medical application of radiohalogenated peptides; Synthesis and ${it in vitro}$ evaluation of F(${it p}$-$$^{131}$$I)KCCYSL for targeting HER2

Sasaki, Ichiro; Watanabe, Shigeki; Ohshima, Yasuhiro; Sugo, Yumi; Yamada, Keiichi*; Hanaoka, Hirofumi*; Ishioka, Noriko

Peptide Science 2015, p.243 - 246, 2016/03

Journal Articles

Geological investigations using cosmic ray muons; A Trial to detect fault at the Mizunami Underground Research Laboratory

Sasao, Eiji; Suzuki, Keiichi*; Yamada, Nobuto*; Kuboshima, Koji*

Proceedings of 12th SEGJ International Symposium (USB Flash Drive), 4 Pages, 2015/11

We performed investigation of a fault with thick and clay-altered damaged zone in granitic rock using cosmic ray muons at the Mizunami Underground Research Laboratory. Geology of the Laboratory consists of sedimentary rock and underlying granite with unconformable contact at the 170 meters below ground level (G.L.). A vertical fault with a thick, clay-altered damaged zone is present in the granite. The muon telescopes were settled at the G.L.-200 and -300 meters to estimate densities of granite and fault. Densities of granite, fault and sedimentary rock are calculated as 3.38, 2.88 and 1.99 g/cm$$^{3}$$, respectively. The obtained density is obviously higher than absolute value, though the reason of such difference is not clear at the moment. If the density of granite is assumed to be 2.6 g/cm$$^{3}$$, then the densities of fault and sedimentary rock are re-calculated as 2.2 and 1.5 g/cm$$^{3}$$. This result indicates that cosmic ray muons have good potential to detect geological structure.

Journal Articles

Insights into the proton transfer mechanism of a bilin reductase PcyA following neutron crystallography

Unno, Masayoshi*; Ishikawa, Kumiko*; Kusaka, Katsuhiro*; Tamada, Taro; Hagiwara, Yoshinori*; Sugishima, Masakazu*; Wada, Kei*; Yamada, Taro*; Tomoyori, Katsuaki; Hosoya, Takaaki*; et al.

Journal of the American Chemical Society, 137(16), p.5452 - 5460, 2015/04

 Times Cited Count:23 Percentile:65.97(Chemistry, Multidisciplinary)

Phycocyanobilin, a light-harvesting and photoreceptor pigment in higher plants, algae, and cyanobacteria, is synthesized from biliverdin IX$$alpha$$ (BV) by phycocyanobilin:ferredoxin oxidoreductase (PcyA) via two steps of two-proton-coupled two-electron reduction. We determined the neutron structure of PcyA from cyanobacteria complexed with BV, revealing the exact location of the hydrogen atoms involved in catalysis. Notably, approximately half of the BV bound to PcyA was BVH$$^{+}$$, a state in which all four pyrrole nitrogen atoms were protonated. The protonation states of BV complemented the protonation of adjacent Asp105. The "axial "water molecule that interacts with the neutral pyrrole nitrogen of the A-ring was identified. His88 N$$delta$$ was protonated to form a hydrogen bond with the lactam O atom of the BV A-ring. His88 and His74 were linked by hydrogen bonds via H$$_{3}$$O$$^{+}$$. These results imply that Asp105, His88, and the axial water molecule contribute to proton transfer during PcyA catalysis.

Journal Articles

Exploring of peptides with affinity to HER2 from random peptide libraries using radioisotope; Random hexapeptide libraries with fixed amino acid sequence at 1 and 2 positions

Sasaki, Ichiro; Hanaoka, Hirofumi*; Yamada, Keiichi*; Watanabe, Shigeki; Sugo, Yumi; Ohshima, Yasuhiro; Suzuki, Hiroyuki; Ishioka, Noriko

Peptide Science 2014, p.257 - 260, 2015/03

Journal Articles

Synthesis of radiohalogen-labeled peptide with high affinity to HER2/neu receptor

Sasaki, Ichiro; Yamada, Keiichi*; Watanabe, Shigeki; Hanaoka, Hirofumi*; Sugo, Yumi; Oku, Hiroyuki*; Ishioka, Noriko

JAEA-Review 2013-059, JAEA Takasaki Annual Report 2012, P. 96, 2014/03

Journal Articles

Synthesis of radiohalogen-labeled peptides with high affinity to HER2/neu receptor

Sasaki, Ichiro; Yamada, Keiichi*; Watanabe, Shigeki; Hanaoka, Hirofumi*; Sugo, Yumi; Oku, Hiroyuki*; Ishioka, Noriko

Peptide Science 2013, p.157 - 160, 2013/03

Journal Articles

Synthesis of radioiodinated antitumor cyclic peptide, [$$^{125}$$I]-sansalvamide A derivative

Watanabe, Shigeki; Yamada, Keiichi*; Tsukui, Narutaka*; Hanaoka, Hirofumi*; Ohshima, Yasuhiro; Yamaguchi, Aiko*; Oku, Hiroyuki*; Ishioka, Noriko

JAEA-Review 2012-046, JAEA Takasaki Annual Report 2011, P. 88, 2013/01

Journal Articles

Development of a $$^{76}$$Br-labeled amino acid derivative for PET imaging of tumor

Hanaoka, Hirofumi*; Watanabe, Shigeki; Tominaga, Hideyuki*; Ohshima, Yasuhiro; Watanabe, Satoshi; Yamada, Keiichi*; Iida, Yasuhiko*; Ishioka, Noriko; Endo, Keigo*

JAEA-Review 2012-046, JAEA Takasaki Annual Report 2011, P. 89, 2013/01

no abstracts in English

Journal Articles

Evaluation of $$^{64}$$Cu-labeled DOTA-$$_{rm D}$$-Phe$$^{1}$$-Tyr$$^{3}$$-octreotide ($$^{64}$$Cu-DOTA-TOC) for imaging somatostatin receptor-expressing tumors

Hanaoka, Hirofumi*; Tominaga, Hideyuki*; Yamada, Keiichi*; Paudyal, P.*; Iida, Yasuhiko*; Watanabe, Shigeki; Paudyal, B.*; Higuchi, Tetsuya*; Oriuchi, Noboru*; Endo, Keigo*

Annals of Nuclear Medicine, 23(6), p.559 - 567, 2009/08

 Times Cited Count:16 Percentile:49.88(Radiology, Nuclear Medicine & Medical Imaging)

Journal Articles

Nano-particle materials prepared from a synthetic antigenic sequence of ${it plasmodium falciparum}$ enolase

Oku, Hiroyuki*; Yamada, Keiichi*; Kobayashi, Kyoko*; Katakai, Ryoichi*; Ashfaq, M.*; Hanaoka, Hirofumi*; Iida, Yasuhiko*; Endo, Keigo*; Hasegawa, Shin; Maekawa, Yasunari; et al.

Peptide Science 2008, p.439 - 442, 2009/03

Malaria is the major cause of mortality and morbidity in the tropical and subtropical regions in the world. Our previous studies have shown that a series of partial peptides of a Plasmodium falciparum enolase have antigenic reactivity against patients' sera. In this paper, we wish to report nano-encapsulation of a synthetic antigen into bioabsorbable polymer particles and their releasing studies in vitro and in vivo.

Journal Articles

Generation of broadband mid-infrared pulses by noncollinear difference frequency mixing

Sugita, Akihiro; Yokoyama, Keiichi; Yamada, Hidetaka; Inoue, Norihiro*; Aoyama, Makoto; Yamakawa, Koichi

Japanese Journal of Applied Physics, Part 1, 46(1), p.226 - 228, 2007/01

 Times Cited Count:5 Percentile:23.89(Physics, Applied)

Generation of broadband mid-infrared (MIR) laser pulses by difference frequency mixing (DFM) is reported. Two-color femtosecond pulses from a Ti: Sapphire laser system is mixed in an AgGaS$$_{2}$$ crystal utilizing a noncollinear phase matching scheme. The relative bandwidth of the generated MIR pulse has been measured to be 23 % to the central frequency, the broadest in DFM-based MIR sources reported so far. It is found that the type-I crystal can give broader phase matching range of spectrum than the type-II crystal within this scheme.

Journal Articles

Selective transition to the closely-lying states Cs(7$$D$$$$_{3/2}$$) and Cs(7$$D$$$$_{5/2}$$) by femtosecond laser pulses

Yamada, Hidetaka; Yokoyama, Keiichi; Teranishi, Yoshiaki*; Sugita, Akihiro; Shirai, Toshizo*; Aoyama, Makoto; Akahane, Yutaka; Inoue, Norihiro*; Ueda, Hideki*; Yamakawa, Koichi; et al.

Physical Review A, 72(6), p.063404_1 - 063404_5, 2005/12

 Times Cited Count:6 Percentile:32.38(Optics)

A demonstration of coherent quantum control for ultrafast precise selection of closely-lying states is reported. A phase-locked pair of femtosecond laser pulses is generated through a pulse shaper to excite the ground-state cesium atom to the Cs(7$$D$$$$_{3/2}$$) and Cs(7$$D$$$$_{5/2}$$) states by two-photon absorption. The excited state population is measured by detecting fluorescence from each spin-orbit state. By controlling the phase-difference of the pulse pair, an ultrafast precise selection is accomplished. The contrast ratio of the maximal to minimal selection ratio exceeds 10$$^3$$ with the delay less than 400 fs.

Journal Articles

Optimal control of ultrafast selection

Yokoyama, Keiichi; Teranishi, Yoshiaki; Toya, Yukio; Shirai, Toshizo; Fukuda, Yuji; Aoyama, Makoto; Akahane, Yutaka; Inoue, Norihiro*; Ueda, Hideki; Yamakawa, Koichi; et al.

Journal of Chemical Physics, 120(20), p.9446 - 9449, 2004/05

 Times Cited Count:6 Percentile:19.84(Chemistry, Physical)

Optimal laser control for ultrafast selection of closely-lying excited states, whose energy separation is smaller than the laser bandwidth, is reported on the two-photon transition of atomic cesium; Cs(6S $$rightarrow$$ 7D$$_{J}$$, J = 5/2 and 3/2). Selective excitation was carried out by pulse shaping of ultrashort laser pulses which were adaptively modulated in a closed-loop learning system handling eight parameters representing the electric field. Two-color fluorescence from the respective excited states was monitored to measure the selectivity. The fitness used in the learning algorithm was evaluated from the ratio of the fluorescence yield. After fifty generations, a pair of nearly transform-limitted pulses were obtained as an optimal pulse shape, proving the effectiveness of "Ramsey fringes" mechanism. The contrast of the selection ratio was improved by $$sim$$ 30 % from the simple "Ramsey fringes" experiment.

Journal Articles

None

; Oi, Keiichi*; Yamada, Kazuyoshi*; *; *; Ise, Akihiro*

Gekkan Chikyu, p.463 - 468, 1997/00

None

Oral presentation

State-selective excitation of potassium atoms by the phase control in the strong field regime

Sugita, Akihiro; Yokoyama, Keiichi; Itakura, Ryuji; Yamada, Hidetaka

no journal, , 

Selective excitation to the closely lying state of potassiium atoms were examined as a fundamental research of a new laser-isotope-separation technique. Using time-resolved photon counting to measure the fluorescence intensity, the scatterd light from the pump beam and the fluorescence of interest were perfectly distinguished. Owing to this experimental setup, a high contrast more than 1000 was obtained for the selectivity. In addition, the excitation behavior when the laser intensity increased was recorded through the laser power dependence of the fluorescence intensity. As a result, it is found that the destructive interference between two excited states becomes incomplete with increasing laser power. Moreover, the relative population of the two states exhibit the power dependence expected by a computer simulation, indicating that the laser power required for the selective complete excitation is achieved.

Oral presentation

Synthesis of radiobrominated aromatic amino acid derivatives for in vivo imaging of bioactive peptides

Tsukui, Narutaka; Watanabe, Shigeki; Yamada, Keiichi*; Hanaoka, Hirofumi*; Oku, Hiroyuki*; Matsuo, Ichiro*; Endo, Keigo*; Ishioka, Noriko

no journal, , 

no abstracts in English

Oral presentation

Synthesis of Br-77 labeled aromatic amino acid derivatives for applications to radiolabeled peptides

Tsukui, Narutaka; Watanabe, Shigeki; Hanaoka, Hirofumi*; Yamada, Keiichi*; Oku, Hiroyuki*; Ishioka, Noriko; Endo, Keigo*; Matsuo, Ichiro*

no journal, , 

no abstracts in English

Oral presentation

Usefullness of $$^{76}$$Br-labeled amino acid derivative for PET imaging of tumor

Hanaoka, Hirofumi*; Watanabe, Shigeki; Tominaga, Hideyuki*; Ohshima, Yasuhiro; Tsukui, Narutaka; Watanabe, Satoshi; Yamada, Keiichi*; Iida, Yasuhiko*; Oriuchi, Noboru*; Higuchi, Tetsuya*; et al.

no journal, , 

no abstracts in English

Oral presentation

Solid-phase synthesis of cyclic peptides containing p-(tri-n-butyl-stannyl)-phenylalanine residue

Tsukui, Narutaka; Yamada, Keiichi*; Watanabe, Shigeki; Hanaoka, Hirofumi*; Oku, Hiroyuki*; Endo, Keigo*; Ishioka, Noriko; Matsuo, Ichiro*

no journal, , 

37 (Records 1-20 displayed on this page)