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Journal Articles

Study of charged particle activation analysis, 2; Determination of boron concentration in human blood samples

Ikebe, Yurie*; Oshima, Masumi*; Bamba, Shigeru*; Asai, Masato; Tsukada, Kazuaki; Sato, Tetsuya; Toyoshima, Atsushi*; Bi, C.*; Seto, Hirofumi*; Amano, Hikaru*; et al.

Applied Radiation and Isotopes, 164, p.109106_1 - 109106_7, 2020/10

Boron Neutron Capture Therapy (BNCT) is a radiotherapy for the treatment of intractable cancer. In BNCT precise determination of $$^{10}$$B concentration in whole blood sample before neutron irradiation is crucial for control of the neutron irradiation time and the neutron dosimetry. We have applied the Charged Particle Activation Analysis (CPAA) to non-destructive and accurate determination of $$^{10}$$B concentration in whole blood sample. The experiment was performed at JAEA Tandem Accelerator using an 8 MeV proton beam. The 478 keV $$gamma$$ ray of $$^{7}$$Be produced in the $$^{10}$$B(p,$$alpha$$)$$^{7}$$Be reaction was used to quantify the $$^{10}$$B, and $$gamma$$ rays of $$^{56}$$Co originating from the reaction with Fe in blood was used to normalize the $$gamma$$-ray intensity. The results demonstrated that the present CPAA method can be applied to the determination of the $$^{10}$$B concentration in the blood sample.

Journal Articles

Beam commissioning of the linac for iBNCT

Naito, Fujio*; Anami, Shozo*; Ikegami, Kiyoshi*; Uota, Masahiko*; Ouchi, Toshikatsu*; Onishi, Takahiro*; Oba, Toshiyuki*; Obina, Takashi*; Kawamura, Masato*; Kumada, Hiroaki*; et al.

Proceedings of 13th Annual Meeting of Particle Accelerator Society of Japan (Internet), p.1244 - 1246, 2016/11

The proton linac installed in the Ibaraki Neutron Medical Research Center is used for production of the intense neutron flux for the Boron Neutron Capture Therapy (BNCT). The linac consists of the 3-MeV RFQ and the 8-MeV DTL. Design average beam current is 10mA. Target is made of Beryllium. First neutron production from the Beryllium target was observed at the end of 2015 with the low intensity beam as a demonstration. After the observation of neutron production, a lot of improvement s was carried out in order to increase the proton beam intensity for the real beam commissioning. The beam commissioning has been started on May 2016. The status of the commissioning is summarized in this report.

Journal Articles

Determination of the compound biological effectiveness (CBE) factors based on the ISHIYAMA-IMAHORI deterministic parsing model with the dynamic PET technique

Ishiyama, Shintaro; Imahori, Yoshio*; Itami, Jun*; Koivunoro, H.*

Global Journal of Medical Research; F, 15(4), p.1 - 5, 2015/11

In defining the biological effects of the neutron capture reaction, we have proposed a deterministic parsing model (ISHIYAMA-IMAHORI model) to determine the Compound Biological Effectiveness (CBE) factor in Borono-Phenyl-Alanine (BPA)-mediated Boron Neutron Capture Therapy (BNCT). To determine the CBE factor, we derived new calculation formula founded on the deterministic parsing model with three constants, CBE0, F, n and the eigen value Nth/Nmax. where, Nth and Nmax are the threshold value of boron concentration of N and saturation boron density. In order to determine Nth and Nmax in the formula, sigmoid logistic function was employed for $$^{10}$$B concentration data, Db(t) obtained by dynamic PETtechnique, where, A, a and t0 are constants. From the application of sigmoid function to dynamic PET data, it is concluded that the Nth and Nmax for tissue and tumor are identified with the parameter constants in the sigmoid function in tion as: th b at 0 and max N = D t = N = x.

Journal Articles

Determination of the Compound Biological Effectiveness (CBE) factors based on the ISHIYAMA-IMAHORI deterministic parsing model with the dynamic PET technique

Ishiyama, Shintaro; Imahori, Yoshio*; Itami, Jun*; Koivunoro, H.*

Journal of Cancer Therapy, 6(8), p.759 - 766, 2015/08

From the concentration of 10BPA drug was intravenously injected into the tumor and normal cells of brain tumor patients measured by dynamic PET method, the CBE factor for the BNCT treatment can be calculated by using ISHIYAMA-IMAHORI model.

Journal Articles

Improvement of dose calculation accuracy for BNCT dosimetry by the multi-voxel method in JCDS

Kumada, Hiroaki; Yamamoto, Kazuyoshi; Yamamoto, Tetsuya*; Nakai, Kei*; Nakagawa, Yoshinobu*; Kageji, Teruyoshi*; Matsumura, Akira*

Applied Radiation and Isotopes, 61(5), p.1045 - 1050, 2004/11

 Times Cited Count:9 Percentile:44.08(Chemistry, Inorganic & Nuclear)

To carry out the BNCT clinical trials based on accurate dosimetry of several absorbed doses given to a patient, we have developed JCDS which can determine the absorbed doses by numerical simulation. The aim of this study is to improve the accuracy of the BNCT dosimetry efficiently. We have developed the multi-voxel calculation method reconstructing the original voxel model by combining of several voxel cell sizes such as in 5mm, 10mm and 20mm voxel cell. To verify the accuracy of the multi-voxel method, the calculation results were compared with the phantom experimental data. These results proved that the multi-voxel calculation enables JCDS to more accurately estimate the absorbed doses to a patient by efficient calculations.

Journal Articles

Radiation injury of boron neutron capture therapy using mixed epithermal- and thermal neutron beams in patients with malignant glioma

Kageji, Teruyoshi*; Nagahiro, Shinji*; Mizobuchi, Keiji*; Toi, Hiroyuki*; Nakagawa, Yoshinobu*; Kumada, Hiroaki

Applied Radiation and Isotopes, 61(5), p.1063 - 1067, 2004/11

 Times Cited Count:7 Percentile:52.27(Chemistry, Inorganic & Nuclear)

no abstracts in English

Journal Articles

Current clinical results of the Tsukuba BNCT trial

Yamamoto, Tetsuya*; Matsumura, Akira*; Nakai, Kei*; Shibata, Yasushi*; Endo, Kiyoshi*; Sakurai, Fumio; Kishi, Toshiaki; Kumada, Hiroaki; Yamamoto, Kazuyoshi; Torii, Yoshiya

Applied Radiation and Isotopes, 61(5), p.1089 - 1093, 2004/11

 Times Cited Count:41 Percentile:6.85(Chemistry, Inorganic & Nuclear)

no abstracts in English

Journal Articles

Verification of the JAERI Computational Dosimetry System (JCDS) for boron neutron capture therapy

Kumada, Hiroaki; Yamamoto, Kazuyoshi; Torii, Yoshiya; Matsumura, Akira*; Nakagawa, Yoshinobu*

Japanese Journal of Medical Physics, Vol.23, Supplement 3, p.292 - 295, 2003/09

no abstracts in English

JAEA Reports

Development of the JAERI Computational Dosimetry System (JCDS) for boron neutron capture therapy (Cooperative research)

Kumada, Hiroaki; Yamamoto, Kazuyoshi; Torii, Yoshiya; Matsumura, Akira*; Yamamoto, Tetsuya*; Nose, Tadao*; Nakagawa, Yoshinobu*; Kageji, Teruyoshi*; Uchiyama, Junzo

JAERI-Tech 2003-002, 49 Pages, 2003/03

JAERI-Tech-2003-002.pdf:5.22MB

no abstracts in English

Journal Articles

Verification of the JAERI computational dosimetry system for neutron capture therapy

Kumada, Hiroaki; Matsumura, Akira*; Nakagawa, Yoshinobu*; Yamamoto, Tetsuya*; Yamamoto, Kazuyoshi; Torii, Yoshiya

Research and Development in Neutron Capture Therapy, p.529 - 534, 2002/09

no abstracts in English

Journal Articles

Development of the multi-leaf collimator for neutron capture therapy

Kumada, Hiroaki; Kishi, Toshiaki; Hori, Naohiko; Yamamoto, Kazuyoshi; Torii, Yoshiya

Research and Development in Neutron Capture Therapy, p.115 - 119, 2002/09

no abstracts in English

Journal Articles

Comparison of patient brain dose measurements and the JCDS calculation

Yamamoto, Tetsuya*; Matsumura, Akira*; Yamamoto, Kazuyoshi; Kumada, Hiroaki; Torii, Yoshiya; Endo, Kiyoshi*; Matsushita, Akira*; Shibata, Yasushi*; Nose, Tadao*

Research and Development in Neutron Capture Therapy, p.415 - 418, 2002/09

Dose measurements in a patient's brain undergoing intraoperative BNCT (IOBNCT) were compared with calculations by a JAERI computational dosimetry system (JCDS). The maximum thermal neutron flux on the brain surface from the postirradiation measurement averaged 2.33$$pm$$0.37($$times$$10$$^{9}$$cm$$^{-2}$$s$$^{-1}$$) and the vascular boron dose averaged 11.4$$pm$$1.2 (9.6-12.7) Gy. Using JCDS, the maximum thermal neutron flux in the irradiated volume averaged 2.21$$pm$$0.33($$times$$10$$^{9}$$cm$$^{-2}$$s$$^{-1}$$), while the target vascular dose averaged 5.7 Gy and varied from 3.5 to 7.8 Gy. As such, in the dose planning for intra-operative irradiation, practical use of JCDS is recommended for uniform volume-dose control of postsurgical brain in IOBNCT.

Journal Articles

Failure pattern in the patients who underwent intraoperative boron neutron capture therapy (IOBNCT)

Nakai, Kei*; Matsumura, Akira*; Yamamoto, Tetsuya*; Shibata, Yasushi*; Zhang, T.*; Akutsu, Hiroyoshi*; Matsuda, M.*; Matsushita, Akira*; Yasuda, Susumu*; Takano, Shingo*; et al.

Research and Development in Neutron Capture Therapy, p.1135 - 1138, 2002/09

7 patients have been undergoing Intraoperative boron neutron capture therapy (IOBNCT) for malignant glioma at Japan Atomic Energy Institute (JAERI). Post-BNCT MRI studies revealed one local recurrence and two distant recurrences. Distant recurrence is uncommon in the conventional radiation therapy. Symptomatic late radiation necrosis occurred in one case.

Journal Articles

An Application to Intraoperative BNCT using epithermal neutron of new JRR-4 mode "Epi-12"

Matsushita, Akira*; Yamamoto, Tetsuya*; Matsumura, Akira*; Nose, Tadao*; Yamamoto, Kazuyoshi; Kumada, Hiroaki; Torii, Yoshiya; Kashimura, Takanori*; Otake, Shinichi*

Research and Development in Neutron Capture Therapy, p.141 - 143, 2002/09

A thermal-epithermal mixed beam "Thermal Neutron Beam Mode I" was used in the eleven sessions of boron neutron capture therapy which have been performed at JRR-4 from 1998. We are planning to use an epithermal beam for the treatment of deeper tumors in the next trial of the intraoperative BNCT. In this study, "Epi-12" which was made by putting up a cadmium shutter of "Thermal Neutron Beam Mode I" was investigated for the clinical benefits and safety by epithermal beams. Decrease of fast neutron contamination ratio in Epi-12 mode is the advantage for BNCT, particular in the intraoperative BNCT. Because fast neutron on the brain surface is one of the critical factors in the intraoperative BNCT in which the plain beam directly interacts the normal structures. Furthermore a mixture of mode Epi-12 and Th-12 will provide various dose distribution designs. It may be used as a new method to control the best distribution for individual tumors.

Journal Articles

Clinical review of boron neutron capture therapy and a proposed strategy using epithermal neutron beams in Japan

Nakagawa, Yoshinobu*; Pooh, K. H.*; Kageji, Teruyoshi*; Uyama, Shinichi*; Kobayashi, Toru*; Sakurai, Yoshinori*; Matsumura, Akira*; Yamamoto, Tetsuya*; Kumada, Hiroaki

Research and Development in Neutron Capture Therapy, p.1113 - 1116, 2002/09

To make a new protocol using epithermal neutron beam for high-grade glioma patients, we elucidated the relationship between the radiation dose, histological tumor grade, and clinical outcome. One hundred and eighty-three patients with kinds of brain tumors were treated by BNCT since 1968, however, we performed a retrospective study of 105 patients with glial tumors treated in Japan between 1978 and 1997. As for the radiation side effect, we analyzed all patients(n=159) treated between 1977 and 2001. Ten patients with glioblastoma were treated according to the new protocol using epithermal neutron.

Journal Articles

Development of the patient setting system for medical irradiation with research reactor

Kumada, Hiroaki; Matsumura, Akira*; Nakagawa, Yoshinobu*

Nippon Genshiryoku Gakkai Wabun Rombunshi, 1(1), p.59 - 68, 2002/03

no abstracts in English

JAEA Reports

Journal Articles

JRR-4 Medical irradiation facility

Torii, Yoshiya; Yamamoto, Kazuyoshi; Hori, Naohiko; Kumada, Hiroaki; Horiguchi, Yoji

JAERI-Conf 2001-017, p.352 - 356, 2001/11

no abstracts in English

Journal Articles

Development of computational dosimetry system and measurement of dose distribution in water head phantom for BNCT in JAERI

Kumada, Hiroaki; Yamamoto, Kazuyoshi; Torii, Yoshiya; Matsumura, Akira*; Yamamoto, Tetsuya*; Nakagawa, Yoshinobu*; Horiguchi, Yoji

JAERI-Conf 2001-017, p.357 - 362, 2001/11

no abstracts in English

Journal Articles

Treatment of malignant brain tumors using nuclear reactor

Matsumura, Akira*; Yamamoto, Tetsuya*; Shibata, Yasushi*; Nose, Tadao*; Yamamoto, Kazuyoshi; Kumada, Hiroaki; Torii, Yoshiya

Nippon Genshiryoku Gakkai-Shi, 43(10), p.957 - 963, 2001/10

 Times Cited Count:2 Percentile:79.11(Nuclear Science & Technology)

no abstracts in English

54 (Records 1-20 displayed on this page)