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JAEA Reports

Survey of LEU based $$^{99m}$$Tc generators loading process

Tanimoto, Masataka; Amaya, D.*; Aoyama, Masashi; Kimura, Akihiro; Izumo, Hironobu; Tsuchiya, Kunihiko

JAEA-Review 2011-012, 13 Pages, 2011/06

JAEA-Review-2011-012.pdf:2.1MB

$$^{99m}$$Tc is most commonly used as a radiopharmaceutical in the field of nuclear medicine, accounting for more than 80% of all diagnostic nuclear medicine procedure. The $$^{99m}$$Tc is obtained from $$^{99}$$Mo, which is produced by fission of $$^{235}$$U ((n, f) method) and the neutron capture (n, $$gamma$$) method using the $$^{98}$$Mo target. However, a supplying of $$^{99}$$Mo is only depends on imports from any other countries, so JAEA find a way out at domestic production of a part of $$^{99}$$Mo that (n, $$gamma$$) method in cooperation with the industrial circles. On the other hand, INVAP has been working in the supply of $$^{99}$$Mo production facilities using LEU. This report provides descriptions the detail technical aspects related to the facility and operations for loading $$^{99m}$$Tc generator. These key issues and technical provided in this report is believed to be useful for developing and updating them.

JAEA Reports

Survey of LEU based $$^{99}$$Mo production process

Tanimoto, Masataka; Amaya, D.*; Aoyama, Masashi; Kimura, Akihiro; Izumo, Hironobu; Tsuchiya, Kunihiko

JAEA-Review 2011-002, 26 Pages, 2011/03

JAEA-Review-2011-002.pdf:1.46MB

Recently, worldwide demand of $$^{99}$$Mo became rises. However the availability and supply of $$^{99}$$Mo for the manufacturing of generators has been a matter of concern. Concern arose from several factors including, amongst others, the shutdown of some nuclear reactors at Canada (NRU, etc.), uncertainty of reliable operating condition for radioisotope production and difficulties in the availability of highly enriched $$^{235}$$U (HEU) target material used in the majority of the production facilities. As countermeasure for this issue, the HEU is not used but $$^{99}$$Mo production from low enriched $$^{235}$$U (LEU) is performed. This production process was developed in Argentina by the Argentine Atomic Energy Commission (CNEA). In the last ten years, INVAP has been working in the supply of $$^{99}$$Mo production facilities using LEU. This report provides descriptions for the detail technical aspects related to a $$^{99}$$Mo production system using irradiated LEU targets.

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