Rational evaluation of the therapeutic effect and dosimetry of auger electrons for radionuclide therapy in a cell culture model

Shinohara, Ayaka*; Hanaoka, Hirofumi*; Sakashita, Tetsuya*; Sato, Tatsuhiko; Yamaguchi, Aiko*; Ishioka, Noriko*; Tsushima, Yoshito*

Annals of Nuclear Medicine, 32(2), p.114 - 122, 2018/02

https://doi.org/10.1007/s12149-017-1225-9

Radionuclide therapy with low-energy auger electron emitters could potentially provide high anti-tumor efficacy while keeping normal organs toxicity low. In this study, we evaluated the usefulness of auger electron emitter I and compared it with beta-emitter I for tumor treatment in 2D and 3D cell culture models. The computer simulation model for 2D and 3D cell culture were constructed, and the absorbed radiation dose of I or I in each model were calculated by using a Monte Carlo simulation code (PHITS). The therapeutic effect of I was comparable to that of I in 2D model, but the efficacy was inferior to that of I-MIBG in 3D model, since crossfire effect is negligible and the homogeneous distribution of radionuclide was insufficient.

Clinical significance of L-type amino acid transporter 1 expression as a prognostic marker and potential of new targeting therapy in biliary tract cancer

Kaira, Kyoichi*; Sunose, Yutaka*; Ohshima, Yasuhiro; Ishioka, Noriko; Arakawa, Kazuhisa*; Ogawa, Tetsushi*; Sunaga, Noriaki*; Shimizu, Kimihiro*; Tominaga, Hideyuki*; Oriuchi, Noboru*; et al.

BMC Cancer, 13, p.482_1 - 482_12, 2013/10

https://doi.org/10.1186/1471-2407-13-482

Synthesis of radioiodinated antitumor cyclic peptide, [I]-sansalvamide A derivative

Watanabe, Shigeki; Yamada, Keiichi*; Tsukui, Narutaka*; Hanaoka, Hirofumi*; Ohshima, Yasuhiro; Yamaguchi, Aiko*; Oku, Hiroyuki*; Ishioka, Noriko

JAEA-Review 2012-046, JAEA Takasaki Annual Report 2011, P. 88, 2013/01

https://jopss.jaea.go.jp/pdfdata/JAEA-Review-2012-046.pdf

Synthesis and evaluation of I labeled cyclic peptide, Sansalvamide A

Watanabe, Shigeki; Yamada, Keiichi*; Hanaoka, Hirofumi*; Ohshima, Yasuhiro; Tsukui, Narutaka*; Takano, Chikako*; Yamaguchi, Aiko*; Oku, Hiroyuki*; Iida, Yasuhiko*; Endo, Keigo*; et al.

no journal, , 

no abstracts in English

Biological evaluation of 3-[F]fluoro--methyl-D-tyrosine (D-[F]FAMT) as a novel amino acid tracer for positron emission tomography

Ohshima, Yasuhiro; Hanaoka, Hirofumi*; Tominaga, Hideyuki*; Kanai, Yoshikatsu*; Kaira, Kyoichi*; Yamaguchi, Aiko*; Nagamori, Shushi*; Oriuchi, Noboru*; Tsushima, Yoshito*; Endo, Keigo*; et al.

no journal, , 

Studies on PET imaging of cancer Using Cu-64 ions

Sugo, Yumi; Ohshima, Yasuhiro; Yamaguchi, Aiko*; Hanaoka, Hirofumi*; Ishioka, Noriko

no journal, , 

no abstracts in English