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Kawasaki, Riku*; Sasaki, Yoshihiro*; Nishimura, Tomoki*; Katagiri, Kiyofumi*; Morita, Keiichi*; Sekine, Yurina; Sawada, Shinichi*; Mukai, Sadaatsu*; Akiyoshi, Kazunari*
Advanced Healthcare Materials, 10(9), p.2001988_1 - 2001988_8, 2021/05
Times Cited Count：8 Percentile：60(Engineering, Biomedical)Systems for "protein transduction", the intracellular delivery of functional proteins, are needed to address the deliverability challenges of protein therapy, but protein transfer in vivo remains difficult. In this study, we have developed a magnetically induced in vivo protein transfection system using a magnetic nanogel chaperone (MC) composed of iron oxide nanoparticles and polysaccharide nanogels. Experiments using an oral cancer model have shown that this MC system is useful for cancer treatment.
Hayashi, Katsuhiko; Kishi, Hirokazu; Kabayashi, Yasushi*; Takebe, Atsuji*; Fujiyama, Tetsuo*; Hiramoto, Masayuki*; Mizutani, Kazuhiko*; Morita, Atsushi*
JAEA-Research 2010-059, 92 Pages, 2011/03
JAEA-Research-2010-059.pdf:3.71MB
In this study, the first investigation is the order of the multi-tunnels excavation. The second is the strain-softening model for multi-tunnels which is based on test data at Horonobe site. As results of first investigation, we showed as 2 dimensional analyses that it was desirable to excavate the tunnel of the remote distance at first and excavate the tunnel between these tunnels next, and it is necessary for the examination that reflected a real plan, such as evacuation machine and actual multi tunnel layout. As the results of second investigation, we also showed the more reliable EDZ by using the strain-softening model that is based on test data at Horonobe site. Furthermore, we standardized the design method (draft) for the practical use by referring the past studies of multi tunnel design method.
Hayashi, Katsuhiko; Kishi, Hirokazu; Kabayashi, Yasushi*; Takebe, Atsuji*; Fujiyama, Tetsuo*; Hiramoto, Masayuki*; Mizutani, Kazuhiko*; Morita, Atsushi*
JAEA-Research 2009-056, 86 Pages, 2010/02
JAEA-Research-2009-056.pdf:9.96MB
In this study, the effect of constitutive models such as strain softening of rock masses for EDZ, and the stress relief ratio used for multi tunnels analysis were conducted. As the result, it is necessary to confirm mechanical behavior of in situ rock and it is important to choose suitable constitutive models, and it is possible for all tunnels in multi tunnels model to have same stress relief ratio.
=3 levels observed on MSE spectra of LHD plasmaIwamae, Atsushi; Sakaue, Atsushi*; Atake, Makoto*; Sawada, Keiji*; Goto, Motoshi*; Morita, Shigeru*
Plasma Physics and Controlled Fusion, 51(11), p.115004_1 - 115004_15, 2009/11
Times Cited Count：6 Percentile：23.87(Physics, Fluids & Plasmas)Hayashi, Katsuhiko; Kobayashi, Yasushi; Hiramoto, Masayuki*; Mizutani, Kazuhiko*; Morita, Atsushi*
JAEA-Research 2009-016, 127 Pages, 2009/08
JAEA-Research-2009-016.pdf:5.23MB
"Study on configuration of analytical domain of the multi tunnels model" and "Remainders on an elasto-plastic FEM (Finite Element Method) analysis" in case of the full width of pillar become plastic on simplified model" are studied as "The study on the enhanced reliability of elasto-plastic FEM". In addition, "The effect of rock support and consolidation of the host rock to control the plastic region" was conducted as "The study on the mechanical stability of tunnels". As the results, it was seen that the analytical domain should be assigned 3-5W (W: width of multi tunnels) for a horizontal side from the endmost tunnel and 3-4W for below of the tunnels. It was found reasonable and proper on the elasto-plastic FEM analysis that the analysis domain must be large enough not to have plastic deformation in all analysis of domains under the condition in which the full width of pillar has plastic deformation. It was also found that the ground support suppresses the plasticity domain as the ground support effect. It was acknowledged that the auxiliary construction method by improvement of the ground has the suppression effect of the plasticity domain applying to the multi tunnels.
Hiramoto, Masayuki; Kobayashi, Yasushi; Nakama, Shigeo; Mizutani, Kazuhiko*; Morita, Atsushi*
JAEA-Research 2008-001, 84 Pages, 2008/03
JAEA-Research-2008-001.pdf:13.19MB
In this study, the following studies on the design method of multi-tunnels were performed. Study on the outbreak behavior of EDZ (Chapter 2) Study on the stability evaluation of the pillars (Chapter 3) In Chapter 2, analysis was carried out for "multi-tunnels model" that modeled the gallery group of a disposal panel scale. As a result, it is important to use multi-tunnels models for prediction evaluation of EDZ, because the outbreak behavior of EDZ was different from the model of the H12 report. In Chapter 3, a stability evaluation method of pillars was considered from two viewpoints of "pillar strength" and "pillar load" based on the similar structures. As a result, if numerical analysis by the multi-tunnels model was carried out, pillar strength and pillar load was estimated adequately. Therefore, a stability evaluation method of the pillars in a disposal institution was suggested.
Hiramoto, Masayuki; Kobayashi, Yasushi; Aoyagi, Shigeo*; Miyanomae, Shunichi*; Morita, Atsushi*
JAEA-Research 2007-003, 54 Pages, 2007/03
JAEA-Research-2007-003.pdf:3.67MB
For the study on the long-term stability of near-field rock mass, the following studies were carried out in this report. (1) Inspection of applicability of a valuable-compliance-type constitutive equation that used the measurement data of the existing tunnel. (2) Suggestion of the informatization construction that used a valuable-compliance-type constitutive equation (1) FEM model was developed to estimate the time dependet behavior of rock mass surrounding tunnel. The calculated results such as tunnel convergence and the axial force exerted on tunnel support were compared with the measured results in-situ. It was found that the calculated results reasonably well coincided with the measured results. (2) The informatization construction that used a valuable-compliance-type constitutive equation was suggested. This method will be used for disposal ground construction. It will be led to improving reliability of long-term evaluation after closedown.
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=1.5-2.4 GeVZegers, R. G. T.*; Sumihama, Mizuki*; Ahn, D. S.*; Ahn, J. K.*; Akimune, Hidetoshi*; Asano, Yoshihiro; Chang, W. C.*; Dat
, S.*; Ejiri, Hiroyasu*; Fujimura, Hisako*; et al.
Physical Review Letters, 91(9), p.092001_1 - 092001_4, 2003/08
Times Cited Count：128 Percentile：94.9(Physics, Multidisciplinary)no abstracts in English
= +1 Baryon resonance in photoproduction from the neutronNakano, Takashi*; Ahn, D. S.*; Ahn, J. K.*; Akimune, Hidetoshi*; Asano, Yoshihiro; Chang, W. C.*; Date, S.*; Ejiri, Hiroyasu*; Fujimura, Hisako*; Fujiwara, Mamoru; et al.
Physical Review Letters, 91(1), p.012002_1 - 012002_4, 2003/07
Times Cited Count：1006 Percentile：99.86(Physics, Multidisciplinary)no abstracts in English
