Modeling for predicting survival fraction of cells after ultra-high dose rate irradiation

Shiraishi, Yuta*; Matsuya, Yusuke; Kusumoto, Tamon*; Fukunaga, Hisanori*

Physics in Medicine & Biology, 69(1), p.015017_1 - 015017_14, 2024/01

https://doi.org/10.1088/1361-6560/ad131b

FLASH radiotherapy (FLASH-RT) using ultra-high dose rate ( 40 Gy/sec) is known as a new treatment which is expected to enable preserving normal tissue functions, compared to the conventional radiotherapy (CONV-RT) with high dose rate ( 6 Gy/min). To date, it is believed that the modulation of chemical processes caused by interactions between radiation tracks under FLASH-RT is a key factor in the functional preservation of normal tissues; however, the relationship between changes in chemical processes and cellular responses remains uncertain. In this study, we developed a prediction model (integrated microdosimetric-kinetic (IMK) model for FLASH-RT) taking into account of the relationship between the chemical process and the DNA damage yields (which is the initial response) under ultra-high dose rate irradiation, to investigate the cellular mechanisms. As a result, the developed model considering the chemical-processes dependent change in DNA damage yields successfully reproduced the measured cell-killing effects of both CONV-RT and FLASH-RT for various cell line types. This model development would contribute on not only precisely understanding of cellular mechanisms after FLASH-RT irradiation but also enabling the prediction of therapeutic effects with high precision.

Observation of proton-transfer-coupled spin transition by single-crystal neutron-diffraction measurement

Nakanishi, Takumi*; Hori, Yuta*; Shigeta, Yasuteru*; Sato, Hiroyasu*; Wu, S.-Q.*; Kiyanagi, Ryoji; Munakata, Koji*; Ohara, Takashi; Sato, Osamu*

Physical Chemistry Chemical Physics, 25(17), p.12394 - 12400, 2023/05

https://doi.org/10.1039/D3CP00527E

Present status of J-PARC MUSE

Shimomura, Koichiro*; Koda, Akihiro*; Pant, A. D.*; Natori, Hiroaki*; Fujimori, Hiroshi*; Umegaki, Izumi*; Nakamura, Jumpei*; Tampo, Motonobu*; Kawamura, Naritoshi*; Teshima, Natsuki*; et al.

Journal of Physics; Conference Series, 2462, p.012033_1 - 012033_5, 2023/03

https://doi.org/10.1088/1742-6596/2462/1/012033

Simulation of the self-propagating hydrogen-air premixed flame in a closed-vessel by an open-source CFD code

Thwe Thwe, A.; Terada, Atsuhiko; Hino, Ryutaro; Nagaishi, Ryuji; Kadowaki, Satoshi

Journal of Nuclear Science and Technology, 59(5), p.573 - 579, 2022/05

https://doi.org/10.1080/00223131.2021.1990153

The simulations of the combustion of self-propagating hydrogen-air premixed flame are performed by an open-source CFD code. The flame propagation behavior, flame radius, temperature and pressure are analyzed by varying the initial laminar flame speed and grid size. When the initial laminar speed increases, the thermal expansion effects become strong which leads the increase of flame radius along with the increase of flame surface area, flame temperature and pressure. A new laminar flame speed model derived previously from the results of experiment is also introduced to the code and the obtained flame radii are compared with those from the experiments. The formation of cellular flame fronts is captured by simulation and the cell separation on the flame surface vividly appears when the gird resolution becomes sufficiently higher. The propagation behavior of cellular flame front and the flame radius obtained from the simulations have the reasonable agreement with the previous experiments.

Monitoring technique for detection of nuclear and radioactive materials on major public events

Mochimaru, Takanori*; Koizumi, Mitsuo; Takahashi, Tone; Hironaka, Kota; Kimura, Yoshiki; Sato, Yuki; Terasaka, Yuta; Yamanishi, Hirokuni*; Wakabayashi, Genichiro*

Dai-42-Kai Nihon Kaku Busshitsu Kanri Gakkai Nenji Taikai Kaigi Rombunshu (Internet), 4 Pages, 2021/11

no abstracts in English

Measurement and evaluation of hydrogen production from mixtures of seawater and zeolite in decontamination of radioactive water

Kumagai, Yuta; Nagaishi, Ryuji; Kimura, Atsushi*; Taguchi, Mitsumasa*; Nishihara, Kenji; Yamagishi, Isao; Ogawa, Toru

Insights Concerning the Fukushima Daiichi Nuclear Accident, Vol.4; Endeavors by Scientists, p.37 - 45, 2021/10

Zeolite adsorbents are to be used for decontamination of radioactive water in Fukushima Dai-ichi Nuclear Power Station. Evaluation of hydrogen production by water radiolysis during decontamination is important for safe operation. Thus hydrogen production from the mixture of zeolite adsorbents and seawater was studied because seawater was urgently used as a coolant for the fuels. The hydrogen yield from the mixture decreased at a high weight fraction of zeolites. However, the measured yield was higher than the yield expected from the direct radiolysis of seawater in the mixture, which would decrease proportional to the weight fraction of seawater. The result suggests that the radiation energy deposited to zeolites was involved in the hydrogen formation. From the results, the hydrogen production rate was evaluated to be 3.6 mL/h per ton of radioactive water before decontamination. After the process, it was evaluated to be 1.5 L/h per ton of waste adsorbents due to the high dose rate.

Visualization of the boron distribution in core material melting and relocation specimen by neutron energy resolving method

Abe, Yuta; Tsuchikawa, Yusuke; Kai, Tetsuya; Matsumoto, Yoshihiro*; Parker, J. D.*; Shinohara, Takenao; Oishi, Yuji*; Kamiyama, Takashi*; Nagae, Yuji; Sato, Ikken

JPS Conference Proceedings (Internet), 33, p.011075_1 - 011075_6, 2021/03

https://doi.org/10.7566/JPSCP.33.011075

Measurement of Doppler broadening of prompt gamma-rays from various zirconium- and ferro-borons

Tsuchikawa, Yusuke; Kai, Tetsuya; Abe, Yuta; Oishi, Yuji*; Sun, Y.*; Oikawa, Kenichi; Nakatani, Takeshi; Sato, Ikken

Nuclear Instruments and Methods in Physics Research A, 991, p.164964_1 - 164964_5, 2021/03

https://doi.org/10.1016/j.nima.2020.164964

Peak shape analysis was performed for the energy spectra of Doppler-broadened prompt -rays generated by neutron capture reactions with various boride or boron samples. Significant differences were observed between nonmetallic and metallic borides. Minor differences between the peak shapes of prompt -rays from zirconium- and ferro-borons were evaluated by a peak fitting method. The identification of zirconium- and ferro-borons and other types of borides was estimated.

Development of three-dimensional distribution visualization technology for boron using energy resolved neutron-imaging system (RADEN)

Abe, Yuta; Tsuchikawa, Yusuke; Kai, Tetsuya; Matsumoto, Yoshihiro*; Parker, J. D.*; Shinohara, Takenao; Oishi, Yuji*; Kamiyama, Takashi*; Nagae, Yuji; Sato, Ikken

Proceedings of 2020 International Conference on Nuclear Engineering (ICONE 2020) (Internet), 6 Pages, 2020/08

https://doi.org/10.1115/ICONE2020-16723

Simulation of fluidity, dispersion and mass transfer in an annular centrifugal contactor

Sano, Yuichi; Sakamoto, Atsushi; Takeuchi, Masayuki; Misumi, Ryuta*; Kunii, Kanako*; Todoroki, Kei*; Nishi, Kazuhiko*; Kaminoyama, Meguru*

Kagaku Kogaku Rombunshu, 44(6), p.335 - 340, 2018/11

https://doi.org/10.1252/kakoronbunshu.44.335

Concerning an annular centrifugal contactor which has high throughput and separation performance, the effect of operational condition on fluidic and dispersion behavior, which are important to improve the contactor performance, was investigated by computational fluid dynamics (CFD) analysis based on the turbulence model, and the calculated results were validated by experimental data. The liquid phase in the annular zone was gradually divided into two regions vertically with increasing the rotor speed and decreasing the flowrate, and the liquid flow moved toward the center of the housing bottom was generated in the lower annular zone under any operational condition. The droplet size of the dispersed phase in the annular zone decreased with increasing the rotor speed and decreasing the flowrate. These calculation results showed a good agreement with experimental data. The CFD analysis considering mass transfer between aqueous and organic phases was also attempted, and it was confirmed that the change of extraction performance with the rotor speed showed the same tendency as the experimental result.