High-sensitive XANES analysis at Ce L-edge for Ce in bauxites using transition-edge sensors; Implications for Ti-rich geological samples

Li, W.*; Yamada, Shinya*; Hashimoto, Tadashi; Okumura, Takuma*; Hayakawa, Ryota*; Nitta, Kiyofumi*; Sekizawa, Oki*; Suga, Hiroki*; Uruga, Tomoya*; Ichinohe, Yuto*; et al.

Analytica Chimica Acta, 1240, p.340755_1 - 340755_9, 2023/02

https://doi.org/10.1016/j.aca.2022.340755

no abstracts in English

Comparison of the therapeutic effects of [At]NaAt and [I]NaI in an NIS-expressing thyroid cancer mouse model

Watabe, Tadashi*; Liu, Y.*; Kaneda, Kazuko*; Sato, Tatsuhiko; Shirakami, Yoshifumi*; Oe, Kazuhiro*; Toyoshima, Atsushi*; Shimosegawa, Eku*; Wang, Y.*; Haba, Hiromitsu*; et al.

International Journal of Molecular Sciences (Internet), 23(16), p.9434_1 - 9434_11, 2022/08

https://doi.org/10.3390/ijms23169434

In this study, we compare the therapeutic effect between [At]NaAt and [I]NaI. In vitro analysis of double-stranded DNA break (DSB) and colony formation assay were performed using K1-NIS cells. [At]NaAt induced higher numbers of DSBs and had a reduced colony formation than [I]NaI. In K1-NIS mice, dose-dependent therapeutic effects were observed in both [At]NaAt and [I]NaI. The superior therapeutic effect of [At]NaAt suggests the promising clinical applicability of targeted alpha therapy using [At]NaAt in patients with differentiated thyroid cancer refractory to standard [I]NaI treatment.

J-PARC E07; Systematic study of double strangeness system with hybrid emulsion method

Yoshida, Junya; Akaishi, Takaya; Fujita, Manami; Hasegawa, Shoichi; Hashimoto, Tadashi; Hosomi, Kenji; Ichikawa, Masaya; Ichikawa, Yudai; Imai, Kenichi*; Kim, S.; et al.

JPS Conference Proceedings (Internet), 33, p.011112_1 - 011112_8, 2021/03

https://doi.org/10.7566/JPSCP.33.011112

Individual dosimetry system for targeted alpha therapy based on PHITS coupled with microdosimetric kinetic model

Sato, Tatsuhiko; Furuta, Takuya; Liu, Y.*; Naka, Sadahiro*; Nagamori, Shushi*; Kanai, Yoshikatsu*; Watabe, Tadashi*

EJNMMI Physics (Internet), 8, p.4_1 - 4_16, 2021/01

https://doi.org/10.1186/s40658-020-00350-7

An individual dosimetry system including the function for calculating EQDX was developed based on PHITS coupled with the microdosimetric kinetic model. It enables us to predict the therapeutic and side effects of TAT based on the clinical data largely available from conventional external radiotherapy.

Conceptual design of main magnets for the J-PARC RCS energy upgrade

Tani, Norio; Watanabe, Yasuhiro; Hotchi, Hideaki; Harada, Hiroyuki; Yamamoto, Masanobu; Kinsho, Michikazu; Igarashi, Susumu*; Sato, Yoichi*; Shirakata, Masashi*; Koseki, Tadashi*

Proceedings of 13th Annual Meeting of Particle Accelerator Society of Japan (Internet), p.708 - 711, 2016/11

http://www.pasj.jp/web_publish/pasj2016/proceedings/PDF/MOP1/MOP113.pdf

At the J-PARC Main Ring (MR), there have been various investigation carried out at the moment aiming at the beam operation of MW order. As one of the investigations, a study of the Rapid-Cycling Synchrotron (RCS) magnets was implemented. Increase of the extraction energy of RCS was needed to reduce beam loss, as beam loss in the MR injection region was large under influence of Space Charge effect at the injection beam of 3GeV. Therefore conceptual design of the extraction energy upgrade using dipole and quadrupole magnets of RCS was performed. In this paper, we will report the contents of the study in extraction energy upgrade of RCS magnets and problems which became clear as a result.

Improvement of symbiotic performance of with under high salt conditions using the ion beam mutation breeding

Maruyama, Yudai*; Takeda, Kiyoko*; Tomooka, Norihiko*; Sato, Katsuya; Ono, Yutaka; Yokoyama, Tadashi*

JAEA-Review 2015-022, JAEA Takasaki Annual Report 2014, P. 99, 2016/02

https://doi.org/10.11484/jaea-review-2015-022

Design of injection and extraction at an 8-GeV booster ring and the J-PARC Main Ring for Multi-MW output beam power

Harada, Hiroyuki; Hotchi, Hideaki; Igarashi, Susumu*; Sato, Yoichi*; Koseki, Tadashi

JPS Conference Proceedings (Internet), 8, p.012012_1 - 012012_6, 2015/09

https://doi.org/10.7566/JPSCP.8.012012

The 240-kW output beam power in the J-PARC 50-GeV Main Ring (MR) has been achieved for the 30-GeV user operation with the cycle time of 2.48 sec and the injected beam intensity with the output beam power of 380-kW equivalent from 3-GeV Rapid Cycling Synchrotron (RCS). The target of output beam power in MR is 750-kW by faster cycling and the injected beam intensity of 600-kW equivalent beam from the RCS. The MR are developing the new type power supplies of the MR main magnets and the high-impedance core of the MR RF cavities. The RCS will aim the designed output beam power of 1-MW from the beam commissioning on October 2014 after the peak current upgrade of Linac from 30 to 50-mA. For higher beam power of MR, we have explored the accelerator options. As one of options, 8-GeV Booster Ring (BR) is also designed for increasing the injection energy of the MR. The increasement of injection energy leads to the reducing a space charge force and the increasing the acceptance clearance from the physical aperture of the MR. In this paper, the realistic injection and extraction system of the BR and the new injection system of the MR for Multi-MW output beam power are also described.

Optics tuning for beam collimation in the J-PARC 3-50 beam transport line

Harada, Hiroyuki; Meigo, Shinichiro; Shirakata, Masashi*; Sato, Yoichi*; Tamura, Fumihiko; Tejima, Masaki*; Hashimoto, Yoshinori*; Igarashi, Susumu*; Koseki, Tadashi

JPS Conference Proceedings (Internet), 8, p.012010_1 - 012010_6, 2015/09

https://doi.org/10.7566/JPSCP.8.012010

The J-PARC 3-50BT line is the beam transport line from 3-GeV rapid-cycling synchrotron (RCS) to 50-GeV main ring (MR). The RCS is the high-intensity proton accelerator, where designed beam power is 1 MW, and has the complex source of space charge effect, etc. Therefore, the uncontrolled emittance growth and beam halo increase nonlinearly with the increasing the beam power. Additionally, the physical aperture of MR with 81 mm mrad is smaller than that of RCS with 486 mm mrad. Therefore, the 3-50BT line has the collimators in order to remove the tail or halo of the extracted beam from the RCS. The designed collimator aperture is 54 mm mrad. It is required to measure and optimize the optics parameters in the collimator area for taking full advantage of the beam collimation. Especially, it is very important to make the dispersion functions free in the collimator area and optimize the beta function. This paper will introduce the method of optics measurement and report the result of the measurement and optimization based on the simulation.

Study on engineering technologies in the Mizunami Underground Research Laboratory (FY 2013); Development of recovery and mitigation technology on excavation damage (Contract research)

Fukaya, Masaaki*; Hata, Koji*; Akiyoshi, Kenji*; Sato, Shin*; Takeda, Yoshinori*; Miura, Norihiko*; Uyama, Masao*; Kaneda, Tsutomu*; Ueda, Tadashi*; Toda, Akiko*; et al.

JAEA-Technology 2014-040, 199 Pages, 2015/03

JAEA-Technology-2014-040.pdf:37.2MB

The researches on engineering technology in the Mizunami Underground Research Laboratory (MIU) project consists of (1) development of design and construction planning technologies, (2) development of construction technology, (3) development of countermeasure technology, (4) development of technology for security, and (5) development of technologies for restoration and/or reduction of the excavation damage. The researches on engineering technology such as verification of the initial design were being conducted by using data measured during construction as a part of the second phase of the MIU plan. Examination about the plug for reflood test in the GL-500m Access/Research Gallery-North as part of the development of technologies for restoration and/or reduction of excavation damage were carried out. Specifically, Literature survey was carried out about the plug, based on the result of literature survey, examination of the design condition, design of the plug and rock stability using numerical simulation, selection of materials for major parts, and grouting for water inflow from between rock and plug, were carried out in this study.

Annual report of Nuclear Emergency Assistance and Training Center (April 1, 2013 - March 31, 2014)

Sato, Takeshi; Muto, Shigeo; Akiyama, Kiyomitsu; Aoki, Kazufumi; Okamoto, Akiko; Kawakami, Takeshi; Kume, Nobuhide; Nakanishi, Chika; Koie, Masahiro; Kawamata, Hiroyuki; et al.

JAEA-Review 2014-048, 69 Pages, 2015/02

JAEA-Review-2014-048.pdf:13.91MB

JAEA was assigned as a designated public institution under the Disaster Countermeasures Basic Act and under the Armed Attack Situations Response Act. Based on these Acts, the JAEA has the responsibility of providing technical support to the national government and/or local governments in case of disaster responses or response in the event of a military attack, etc. In order to fulfill the tasks, the JAEA has established the Emergency Action Plan and the Civil Protection Action Plan. In case of a nuclear emergency, NEAT dispatches specialists of JAEA, supplies the national government and local governments with emergency equipment and materials, and gives technical advice and information. In normal time, NEAT provides various exercises and training courses concerning nuclear disaster prevention to those personnel taking an active part in emergency response institutions of the national and local governments, police, fire fighters, self-defense forces, etc. in addition to the JAEA itself. The NEAT also researches nuclear disaster preparedness and response, and cooperates with international organizations. In the FY2013, the NEAT accomplished the following tasks: (1) Technical support activities as a designated public institution in cooperation with the national and local governments, etc. (2) Human resource development, exercise and training of nuclear emergency response personnel for the national and local governments, etc. (3) Researches on nuclear disaster preparedness and response, and sending useful information (4) International contributions to Asian countries on nuclear disaster preparedness and response in collaboration with the international organizations