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Project 6 Meeting Members for Tsukuba International Strategic Zone
JAEA-Review 2021-016, 102 Pages, 2021/11
In December 2011, the Prime Minister designated Tsukuba and some areas in Ibaraki Prefecture as "Comprehensive Special Zones". In the Tsukuba International Strategic Zone, nine advanced research and development (R&D) projects are underway with the goal of promoting industrialization of life innovation and green innovation utilizing the science and technology in Tsukuba. In these projects, the domestic production of medical radioisotope (Technetium-99m, Tc) was certified as a new project in October 2013, and R&D have been performed in collaboration with related organizations with Japan Atomic Energy Agency (JAEA) as the project leader. Japan is the third largest consumer of molybdenum-99 (
Mo) after the United States and Europe, and all
Mo are imported. Supply will be insufficient if overseas reactors are shut down due to trouble or if transportation (air and land transportations) is stopped due to volcanic eruptions and some accidents. Thus, early domestic production of
Mo is strongly required. This project is a technology development aimed at domestic production of
Mo, which is a raw material of
Tc used as a diagnostic agent. This report summarizes the activities carried out in the first and second phase of the domestic production of medical radioisotope (
Tc) (here referred to as the "Project 6") in Tsukuba International Strategic Zone (FY2014-2020).
Ishida, Takuya; Shiina, Takayuki*; Ota, Akio*; Kimura, Akihiro; Nishikata, Kaori; Shibata, Akira; Tanase, Masakazu*; Kobayashi, Masaaki*; Sano, Tadafumi*; Fujihara, Yasuyuki*; et al.
JAEA-Technology 2015-030, 42 Pages, 2015/11
The research and development (R&D) on the production of Mo/
Tc by neutron activation method ((n,
) method) using JMTR has been carried out in the Neutron Irradiation and Testing Reactor Center. The specific radioactivity of
Mo by (n,
) method is extremely low compared with that by fission method ((n,f) method), and as a result, the radioactive concentration of the obtained
Tc solution is also lowered. To solve the problem, we propose the solvent extraction with methyl ethyl ketone (MEK) for recovery of
Tc from
Mo produced by (n,
) method. We have developed the
Mo/
Tc separation/extraction/concentration devices and have carried out the performance tests for recovery of
Tc from
Mo produced by (n,
) method. In this paper, in order to establish an experimental system for
Mo/
Tc production, the R&D results of the system are summarized on the improvement of the devices for high-recovery rate of
Tc, on the dissolution of the pellets, which is the high-density molybdenum trioxide (MoO
) pellets irradiated in Kyoto University Research Reactor (KUR), on the production of
Tc, and on the inspection of the recovered
Tc solutions.
Awaludin, R.*; Gunawan, A. H.*; Lubis, H.*; Sriyono*; Herlina*; Mutalib, A.*; Kimura, Akihiro; Tsuchiya, Kunihiko; Tanase, Masakazu*; Ishihara, Masahiro
Journal of Radioanalytical and Nuclear Chemistry, 303(2), p.1481 - 1483, 2015/02
Times Cited Count:9 Percentile:56.39(Chemistry, Analytical)In this study, the Mo adsorption and
Tc elution mechanism were investigated using SEM-EDS to analyze the elemental composition of the material surfaces before Mo adsorption, after Mo adsorption and after
Tc elution using saline solution. The results were compared with the value of adsorption capacity of the material to irradiated natural Mo and elution yield of
Tc. From the changes of elemental composition in the surface, it was found that molybdate ions were adsorbed into the adsorbent by ion exchange with Cl
ion in the material. On the other hand, it was also revealed that
Tc can be eluted from the material column in TcO
since oxidizing agent was needed in the elution process.
Nishikata, Kaori; Kimura, Akihiro; Ishida, Takuya; Shiina, Takayuki*; Ota, Akio*; Tanase, Masakazu*; Tsuchiya, Kunihiko
JAEA-Technology 2014-034, 34 Pages, 2014/10
As a part of utilization expansion after the Japan Material Testing Reactor (JMTR) re-start, research and development (R&D) on the production of medical radioisotope Mo/
Tc by (n,
) method using JMTR has been carried out in the Neutron Irradiation and Testing Reactor Center of the Japan Atomic Energy Agency.
Mo is usually produced by fission method. On the other hand,
Mo/
Tc production by the (n,
) method has advantages for radioactive waste, cost reduction and non-proliferation. However, the specific radioactivity per unit volume by the (n,
) method is low compared with the fission method, and that is the weak point of the (n,
) method. This report summarizes the investigation of raw materials, the fabrication tests of high-density MoO
pellets by the plasma sintering method for increasing of
Mo contents and the characterization of sintered high-density MoO
pellets.
Hashimoto, Kazuyuki; Fujisaki, Saburo*
Hoshasen To Sangyo, (136), p.17 - 21, 2014/06
no abstracts in English
Kimura, Akihiro; Awaludin, R.*; Shiina, Takayuki*; Tanase, Masakazu*; Kawauchi, Yukimasa*; Gunawan, A. H.*; Lubis, H.*; Sriyono*; Ota, Akio*; Genka, Tsuguo; et al.
Proceedings of 3rd Asian Symposium on Material Testing Reactors (ASMTR 2013), p.109 - 115, 2013/11
Tc is generated by decay of
Mo. Production of
Mo is carried out by (n,f) method with high enriched uranium targets, and the production are currently producing to meet about 95% of global supply. Recently, it is difficult to carry out a stable supply for some problems such as aging of reactors etc. Furthermore, the production has difficulties in nuclear proliferation resistance etc. Thus, (n,
) method has lately attracted considerable attention. The (n,
) method has several advantages, but the extremely low specific activity makes its uses less convenient than (n,f) method. We proposed a method based on the solvent extraction, followed by adsorption of
Tc with alumina column. In this paper, a practical production of
Tc was tried by the method with 1Ci of
Mo produced in MPR-30. The recovery yields were approximately 70%. Impurity of
Mo was less than 4.0
10
% and the radiochemical purity was over 99.2%.
Hiroki, Akihiro; Sato, Yuichi*; Nagasawa, Naotsugu; Ota, Akio*; Seito, Hajime; Yamabayashi, Hisamichi*; Yamamoto, Takayoshi*; Taguchi, Mitsumasa; Tamada, Masao; Kojima, Takuji
Physics in Medicine & Biology, 58(20), p.7131 - 7141, 2013/10
Times Cited Count:20 Percentile:57.94(Engineering, Biomedical)Tsuchiya, Kunihiko; Nishikata, Kaori; Tanase, Masakazu*; Shiina, Takayuki*; Ota, Akio*; Kobayashi, Masaaki*; Yamamoto, Asaki*; Morikawa, Yasumasa*; Takeuchi, Nobuhiro*; Kaminaga, Masanori; et al.
Proceedings of 6th International Symposium on Material Testing Reactors (ISMTR-6) (Internet), 9 Pages, 2013/10
no abstracts in English
Kimura, Akihiro; Awaludin, R.*; Shiina, Takayuki*; Tanase, Masakazu*; Kawauchi, Yukimasa*; Gunawan, A. H.*; Lubis, H.*; Sriyono*; Ota, Akio*; Genka, Tsuguo; et al.
Proceedings of 6th International Symposium on Material Testing Reactors (ISMTR-6) (Internet), 7 Pages, 2013/10
JP, 2011-173260This research is development of Tc production.
Tc is generated by decay of
Mo. The supply of
Mo in Japan depends entirely on the import from foreign countries. Thus, it is needed to supply
Mo stably by the domestic manufacturing. A practical production of
Tc was tried by the method with 1 Ci of
Mo produced in MPR-30. The results showed that the recovery yields were approximately 70%. The concentration of the product obtained was estimated to be corresponding to about 30 GBq (800 mCi)/ml when 150g of MoO
was irradiated for 5 days in MPR-30. Impurity of
Mo was less than 4.4
10
%, which was lower than that of Japanese tentative regulation criteria. The radiochemical purity was higher than 99.8% that cleared the tentative regulation (95%) of Japan.
Fujibuchi, Toshio*; Kawamura, Taku*; Yamanashi, Koichi*; Hiroki, Akihiro; Yamashita, Shinichi*; Taguchi, Mitsumasa; Sato, Yuichi*; Mimura, Koichi*; Ushiba, Hiroaki*; Okihara, Toru*
Journal of Physics; Conference Series, 444(1), p.012089_1 - 012089_4, 2013/06
Times Cited Count:4 Percentile:76.87(Physics, Multidisciplinary)Hiroki, Akihiro; Yamashita, Shinichi; Sato, Yuichi*; Nagasawa, Naotsugu; Taguchi, Mitsumasa
Journal of Physics; Conference Series, 444, p.012028_1 - 012028_4, 2013/06
Times Cited Count:10 Percentile:90.99(Physics, Multidisciplinary)Polymer gel dosimeters consisting of less toxic methacrylate-type monomers such as 2-hydroxyethyl methacrylate (HEMA) and polyethylene glycol 400 dimethacrylate (9G) with hydroxypropyl cellulose (HPC) gel were prepared. We investigated the effect of monomer compositions on the dose response of the polymer gel dosimeter. The HPC gels as a matrix for the polymer gel dosimeter were obtained by electron beam irradiation to 20wt% of HPC aqueous solution. The dried HPC gels were immersed into mixed monomer solutions, and then the swollen gels were vacuum-packed to prepare the polymer gel dosimeters. The polymer gel dosimeters showed cloudiness by exposing to Co
-ray, in which the cloudiness increased with the dose up to 10 Gy. At the same dose, the increase in the cloudiness appeared with increasing concentration of 9G. It was found that the dose response depended on the composition ratio between HEMA and 9G.
Nishikata, Kaori; Kimura, Akihiro; Shiina, Takayuki*; Ota, Akio*; Tanase, Masakazu*; Tsuchiya, Kunihiko
Proceedings of 2012 Powder Metallurgy World Congress & Exhibition (PM 2012) (CD-ROM), 8 Pages, 2013/02
The renewed Japan Materials Testing Reactor (JMTR) will be started from 2012, and it is expected to contribute to many nuclear fields. Especially, in case of Japan, the supplying of Mo depends on imports from foreign countries. Japan Atomic Energy Agency (JAEA) has a plan to produce
Mo, which is the parent nuclide of radiopharmaceutical
Tc, and JAEA has performed the R&D for
Mo production by (n,
) method in JMTR. Generally, molybdenum oxide (MoO
) is the most popular chemical form as irradiation target for the
Mo production. However, the
Mo production capacity is low because of low (n,
) cross section and isotope composition of
Mo in Mo. Thus, it is necessary to fabricate the MoO
pellets with high density for the increase of the
Mo production amount. In this study, MoO
pellets fabricated by a plasma activated sintering were developed and characterization of MoO
pellets was carried out.
Nagai, Yasuki
Radioisotopes, 61(12), p.619 - 624, 2012/12
A new method was proposed to produce Mo by the
Mo(n,2n)
Mo reaction using intense neutrons from an accelerator by us. About 20% of the demand of
Mo in Japan could be obtained constantly by the proposed method. In fact, we have shown that the produced
Mo contained very little RI impurity and the radionuclide purity of
Tc separated from
Mo by sublimation and the labeling efficiency of
Tc-MDP exceed the United States Pharmacopeia requirements for a fission product,
Mo. We expect that the present
Mo production method will be accepted worldwide to ensure the constant domestic supply of
Mo.
Nishikata, Kaori; Kimura, Akihiro; Tsuchiya, Kunihiko; Suzuki, Kunihiko*; Akiyama, Hiroaki*; Nagakura, Masaaki*; Kawauchi, Yukimasa*; Tanase, Masakazu*
Proceedings of 5th International Symposium on Material Testing Reactors (ISMTR-5) (Internet), 9 Pages, 2012/10
In this study, experimental fabrication tests of the high-density MoO pellets were carried out by the Plasma Activated Sintering (PAS) method, which requires relatively lower temperature and shorter time to fabricate the pellets. From the results, the PAS method combined with oxidation process, prior to dissolution into sodium hydroxide solution, is a useful measure to fabricate high-density MoO
Pellets for the future domestic production of
Tc. The irradiation tests and characterization with these pellets will be carried out under the international cooperation.
Tsuchiya, Kunihiko; Tanase, Masakazu*; Takeuchi, Nobuhiro*; Kobayashi, Masaaki*; Hasegawa, Yoshio*; Yoshinaga, Hideo*; Kaminaga, Masanori; Ishihara, Masahiro; Kawamura, Hiroshi
Proceedings of 5th International Symposium on Material Testing Reactors (ISMTR-5) (Internet), 10 Pages, 2012/10
As one of effective uses of the JMTR, JAEA has a plan to produce Mo by (n,
) method, a parent nuclide of
Tc. In case of Japan, the supplying of
Mo depends only on imports from foreign countries. The R&D on production method of
Mo -
Tc has been performed with Japanese industrial users under the cooperation programs. The main R&D items for the production are (1) Fabrication of irradiation target such as the sintered MoO
pellets, (2) Separation and concentration of
Tc by the solvent extraction from Mo solution, (3) Examination of
Tc solution for a medicine, and (4) Mo recycling from Mo generator and solution. In this paper, the status of the R&D is introduced for the production of
Mo -
Tc.
Tanase, Masakazu*; Shiina, Takayuki*; Kimura, Akihiro; Nishikata, Kaori; Fujisaki, Saburo*; Ota, Akio*; Kobayashi, Masaaki*; Yamamoto, Asaki*; Kawauchi, Yukimasa*; Tsuchiya, Kunihiko; et al.
Proceedings of 5th International Symposium on Material Testing Reactors (ISMTR-5) (Internet), 9 Pages, 2012/10
Tc is used as a radiopharmaceutical and manufactured from the parent nuclide of
Mo. Extraction method of
Tc from (n,
)
Mo have been developed, as a part of the industrial use expansion after JMTR will re-start. In this research, the method proposed would be applicable to a practical production of
Tc obtained from (n,
)
Mo in large quantities. The method proposed would be applicable to a practical production of
Tc obtained from (n,
)
Mo in large quantities.
Imaizumi, Tomomi; Miyauchi, Masaru; Ito, Masayasu; Watahiki, Shunsuke; Nagata, Hiroshi; Hanakawa, Hiroki; Naka, Michihiro; Kawamata, Kazuo; Yamaura, Takayuki; Ide, Hiroshi; et al.
JAEA-Technology 2011-031, 123 Pages, 2012/01
The number of research reactors in the world is decreasing because of their aging. However, the planning to introduce the nuclear power plants is increasing in Asian countries. In these Asian countries, the key issue is the human resource development for operation and management of nuclear power plants after constructed them, and also the necessity of research reactor, which is used for lifetime extension of LWRs, progress of the science and technology, expansion of industry use, human resources training and so on, is increasing. From above backgrounds, the Neutron Irradiation and Testing Reactor Center began to discuss basic concept of a multipurpose low-power research reactor for education and training, etc. This design study is expected to contribute not only to design tool improvement and human resources development in the Neutron Irradiation and Testing Reactor Center but also to maintain and upgrade the technology on research reactors in nuclear power-related companies. This report treats the activities of the working group from July 2010 to June 2011 on the multipurpose low-power research reactor in the Neutron Irradiation and Testing Reactor Center and nuclear power-related companies.
Hashimoto, Kazuyuki
FBNews, (420), p.1 - 5, 2011/12
no abstracts in English
Kimura, Akihiro; Sato, Yuichi*; Tanase, Masakazu*; Tsuchiya, Kunihiko
IOP Conference Series; Materials Science and Engineering, 18(4), p.042001_1 - 042001_4, 2011/10
In the medical field, the radioisotopes are indispensable. Especially, Tc is most commonly used as a radiopharmaceutical. However, the supply of
Mo in Japan depends fully on the import from foreign countries. JMTR has a plan to produce a medical isotope of
Mo, the parent nuclide of
Tc by the (n,
) method and a part of the import volume can be covered of the home country. In this plan, it is important to develop the production method of the irradiation targets such as the Molybdenum oxide (MoO
) pellets. However, MoO
is low sublime temperature and it is difficult to produce the pellets with high density. In this study, MoO
pellets were produced by two kinds of production methods. As a result, MoO
pellet of about 70% TD was obtained by CIP and MoO
pellet of over 95% TD was obtained by SPS.
Ishitsuka, Etsuo; Yamabayashi, Hisamichi*; Tanase, Masakazu*; Fujisaki, Saburo*; Sato, Norihito*; Hori, Naohiko; Awaludin, R.*; Gunawan, A. H.*; Lubis, H.*; Mutalib, A.*
JAEA-Technology 2011-019, 18 Pages, 2011/06
Feasibility study of sublimation type Tc master-milker was carried out as a
Mo/
T production development with the JMTR. As the feasibility study, the experimental equipment for sublimation method and wet method with PZC based
Tc solution were tentatively manufactured, and their properties as the master-milker were investigated by comparing two methods with each other. As a result, it was found that the
Tc recovery rate and process time of the sublimation method were about 80% and 1.5 hour, respectively, and the similar values were observed with the wet method. Superior points of the sublimation method are easier operation and reusability of the used MoO
comparing with the wet method. On the other hand, disadvantageous point is that the
Tc recovery rate decreases with the increase of treating amount of MoO
.