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Journal Articles

Radiation injury of boron neutron capture therapy using mixed epithermal- and thermal neutron beams in patients with malignant glioma

Kageji, Teruyoshi*; Nagahiro, Shinji*; Mizobuchi, Keiji*; Toi, Hiroyuki*; Nakagawa, Yoshinobu*; Kumada, Hiroaki

Applied Radiation and Isotopes, 61(5), p.1063 - 1067, 2004/11

 Times Cited Count:7 Percentile:52.27(Chemistry, Inorganic & Nuclear)

no abstracts in English

Journal Articles

Clinical review of the Japanese experience with boron neutron capture therapy and a proposed strategy using epithermal neutron beams

Nakagawa, Yoshinobu*; Pooh, K. H.*; Kobayashi, Toru*; Kageji, Teruyoshi*; Uyama, Shinichi*; Matsumura, Akira*; Kumada, Hiroaki

Journal of Neuro-Oncology, 62(1), p.87 - 99, 2003/04

 Times Cited Count:105 Percentile:17.74

Our concept of boron neutron capture therapy (BNCT) is selective destruction of tumor cells using the heavy-charged particles Yielded through 10B(n, alpha)7 Li reactions. In the analysis of side effects due to radiation, we included all the 159 patients treated between 1977 and 2001. With respect to the radiation dose (i.e. physical dose of boron n-alpha reaction), the new protocol prescribes a minimum tumor volume dose of 15Gy or, alternatively, a minimum target volume dose of 18Gy. The maximum vascular dose should not exceed 15Gy (physical dose of boron n-alpha reaction) and the total amount of gamma rays should remain below 10Gy, including core gamma rays from the reactor and capture gamma in brain tissue. The outcomes for 10 patients who were treated by the new protocol using a new mode composed of thermal and epithermal neutrons are reported.

JAEA Reports

Development of the JAERI Computational Dosimetry System (JCDS) for boron neutron capture therapy (Cooperative research)

Kumada, Hiroaki; Yamamoto, Kazuyoshi; Torii, Yoshiya; Matsumura, Akira*; Yamamoto, Tetsuya*; Nose, Tadao*; Nakagawa, Yoshinobu*; Kageji, Teruyoshi*; Uchiyama, Junzo

JAERI-Tech 2003-002, 49 Pages, 2003/03

JAERI-Tech-2003-002.pdf:5.22MB

no abstracts in English

Journal Articles

Clinical review of boron neutron capture therapy and a proposed strategy using epithermal neutron beams in Japan

Nakagawa, Yoshinobu*; Pooh, K. H.*; Kageji, Teruyoshi*; Uyama, Shinichi*; Kobayashi, Toru*; Sakurai, Yoshinori*; Matsumura, Akira*; Yamamoto, Tetsuya*; Kumada, Hiroaki

Research and Development in Neutron Capture Therapy, p.1113 - 1116, 2002/09

To make a new protocol using epithermal neutron beam for high-grade glioma patients, we elucidated the relationship between the radiation dose, histological tumor grade, and clinical outcome. One hundred and eighty-three patients with kinds of brain tumors were treated by BNCT since 1968, however, we performed a retrospective study of 105 patients with glial tumors treated in Japan between 1978 and 1997. As for the radiation side effect, we analyzed all patients(n=159) treated between 1977 and 2001. Ten patients with glioblastoma were treated according to the new protocol using epithermal neutron.

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