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Stability of $$^{186}$$Re- and $$^{188}$$Re-DMSAs and removal of impurity in the product

Komoto, Kazuki*; Nogawa, Norio*; Sato, Jun*; Makide, Yoshihiro*; Morikawa, Naotake*; Hashimoto, Kazuyuki; Sorita, Takami

Complex compound of $$^{186}$$Re and $$^{188}$$Re with meso-2,3-dimercaptosuccinic acid (DMSA) is expected to be effective against cancerous disease. This compound is synthesized with high radiochemical yield by use of SnCl$$_{2}$$ as reducing reagent. However, the product contains a large amount of SnCl$$_{2}$$ which is harmful to human body. The removal of tin impurity was tested with cation exchange resin. $$^{186}$$Re-DMSA complex was also obtained with high radiochemical yield by use of other harmless reducing agents (L-ascorbic acid, Na$$_{2}$$SO$$_{3}$$, H$$_{3}$$PO$$_{3}$$). Synthesized $$^{186}$$Re-DMSA by use of SnCl$$_{2}$$ was stable in sodium acetate buffer for 5 hours, while survival amount of $$^{186}$$Re-DMSA synthesized by other reducing agents decreased in a short time.

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Japanese

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Meeting title

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2006日本放射化学会年会・第50回放射化学討論会記念大会

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2006/10

Location (city)

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水戸

Location (country)

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日本

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Keywords

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no keyword

Research Facility

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RI製造棟  

Press Release

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Article of JAEA R&D Review

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Cooperating Institute

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東京大学アイソトープ総合センター

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- Accesses

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