Activation mechanism of granulocyte colony-stimulating factor receptor

Tamada, Taro; Honjo, Eijiro; Kuroki, Ryota

The crystal structure of the signaling complex of human granulocyte colony-stimulating factor (GCSF) and ligand binding region of human GCSF receptor (GCSF-R) has been determined to 2.8 resolution. The GCSF:GCSF-R complex formed a 2:2 stoichiometry via a cross-over interaction between the Ig-like domains of GCSF-R and GCSF. The conformation of the complex is quite different to that between human GCSF and the CRH domain of mouse GCSF-R. This cross-over homodimerization necessary for GCSF-R activation is consistent with previously reported thermodynamic and mutational studies.

Language	:	Japanese
Journal	:	Nihon Kessho Gakkai-Shi
Volume	:	48
Number	:	6
Pages	:	p.429 - 435
Publication Year/Month	:	2006/12
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Paper URL	:	https://doi.org/10.5940/jcrsj.48.429
DOI for research data	:	Link to research data related to this paper/report.
Keywords	:	no keyword
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Cooperating Institute	:	キリンビール

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Registration No. : AA20060709
JAEA Abstracts No. :
Paper Submission No. : 4310

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