Modulatory effect of ionizing radiation on food-NaCl associative learning; The Role of subunit of G protein in

Sakashita, Tetsuya; Hamada, Nobuyuki*; Ikeda, Daisuke*; Yanase, Sumino*; Suzuki, Michiyo; Ishii, Naoaki*; Kobayashi, Yasuhiko

Exposure to IR induced an additional decrease in chemotaxis immediately after an acute dose in the transition stage of the salt chemotaxis learning. Chronic irradiation induced negative chemotaxis in the exposed animals, i.e., the primary avoidance response. IR-induced additional decreases in chemotaxis following acute and chronic irradiations were significantly suppressed in the mutant, which was defective in GPC-1 (one of the two subunits of the heterotrimeric G-protein). Chemotaxis to cAMP, but not to lysine and benzaldehyde, was influenced by IR during the food-NaCl associative learning. Our novel findings suggest that IR behaves as a modulator in the salt chemotaxis learning via GPC-1 and a specific neuronal network, and may shed light on the modulatory effect of IR on learning.