検索対象:     
報告書番号:
※ 半角英数字
 年 ~ 
 年

Chelating ion-exchange methods for the preparation of no-carrier-added $$^{64}$$Cu

無担体$$^{64}$$Cu製造のためのキレートイオン交換法

渡邉 茂樹; 渡辺 智; Liang, J. X.; 花岡 宏史*; 遠藤 啓吾*; 石岡 典子

Watanabe, Shigeki; Watanabe, Satoshi; Liang, J. X.; Hanaoka, Hirofumi*; Endo, Keigo*; Ishioka, Noriko

We have developed a production method for no-carrier-added copper-64 ($$^{64}$$Cu) by using chelating resin bearing iminodiacetic acid groups. We optimized the condition for selective separation of radioactive copper by using chelating resin from nickel and cobalt. Radioactive copper was separated completely using 0.1 M and 2 M HCl solution. In production of no-carrier-added $$^{64}$$Cu, the average 87% of $$^{64}$$Cu was isolated from the $$^{64}$$NiO target with high radionuclide purity ($$>$$ 99%). In order to investigate the quality of the obtained $$^{64}$$Cu, metallic impurities contained in the $$^{64}$$Cu solution were analyzed by means of inductive coupled-plasma mass spectroscopy (ICP-MS) and optical emission spectroscopy (ICP-OES). It was observed that extremely low amounts of metal ion were contained in the $$^{64}$$Cu. The $$^{64}$$Cu solution showed high specific activity (average: 594.7 GBq/$$mu$$mol). In this study, the chelating exchange method yielded high-quality of $$^{64}$$Cu sufficient for the synthesis of $$^{64}$$Cu-labeled radiopharmaceuticals and medical applications.

Access

:

- Accesses

InCites™

:

パーセンタイル:21.38

分野:Radiology, Nuclear Medicine & Medical Imaging

Altmetrics

:

[CLARIVATE ANALYTICS], [WEB OF SCIENCE], [HIGHLY CITED PAPER & CUP LOGO] and [HOT PAPER & FIRE LOGO] are trademarks of Clarivate Analytics, and/or its affiliated company or companies, and used herein by permission and/or license.