Comparison of irradiation effects of synchrotron particle beam and laser driven particle beam irradiation in human cancer cell

ヒト癌細胞におけるレーザー駆動粒子線照射とシンクロトロン粒子線照射効果の比較

前田 拓也; 余語 覚文; 出水 祐介*; 堀 利彦; 榊 泰直; 巴 悠介*; 近藤 公伯; 村上 昌雄*

Maeda, Takuya; Yogo, Akifumi; Demizu, Yusuke*; Hori, Toshihiko; Sakaki, Hironao; Tomoe, Yusuke*; Kondo, Kiminori; Murakami, Masao*

The Hyogo Ion Beam Medical Center (HIBMC) was established in May 2001, a leading project of the "Hyogo Cancer Strategy". As its major characteristic, both proton and carbon ion beams can be generated. The accelerator is a synchrotron that can accelerate proton and carbon ion beams at a maximum of 230 and 320 MeV/u, respectively. Three irradiation rooms installed with 45, horizontal/vertical, and horizontal fixed ports can be used for carbon ion radiation biological experiment and therapy. Moreover laser technology to accelerate particle beam therapy, by Japan Atomic Energy Agency (JAEA) advances development now aim to bring innovation to transform conventional treatment, and spread the particle beam therapy, taking advantage of the performance of particle beam therapy, proton therapy equipment laser driven activities are designed to achieve for clinical application to. We have so far, X-ray, proton, and carbon ion beam lines, the laser-driven proton ion beam, has been examined from the standpoint of comparative molecular cell biology of cancer cells to radiation effects. So far, considering the differences in the types of cytostatic effect and the effect of DNA cleavage and on the relevance of apoptosis studies in each lines irradiated cancer cells. In this presentation we reports on the difference of the irradiation effect in X-rays, the proton beam, and the carbon ion beam to the human cancer cell, and it applies on the focus to survival rate after the X-ray, synchrotron proton beam, the synchrotron carbon ion beam, and the laser driven proton is irradiated.