Simplifying wet chemistry isolation of At-211 using PEG column separation

PEGカラムを使ったAt-211湿式分離法の簡略化

Wilbur, D. S.*; Hamlin, D. K.*; Chyan, M.-K.*; Gagnon, K.*; Balkin, E. R.*; 渡辺 茂樹

Wilbur, D. S.*; Hamlin, D. K.*; Chyan, M.-K.*; Gagnon, K.*; Balkin, E. R.*; Watanabe, Shigeki

Our desire to obtain higher and more consistent recovery of At-211 from large irradiated bismuth tagrets led to the refinement of a wet chemistry approach for isolation of At-211. The wet chemistry approach has provided very consistent isolation yields (75%) with no failures in over 200 irradiations. However, our desire to automate the process has been stymied by the miscibility and differential compressibility of the diisopropyl ether (DIPE) used in an extraction step in the process. As an alternative alkylether extractant to replace DIPE, we have investigated columns that contain polyethylene glycol (PEG) bound to a solid supoort.