Prognostic significance of amino-acid transporter expression (LAT1, ASCT2, and xCT) in surgically resected tongue cancer

豊田 実*; 解良 恭一*; 大島 康宏; 石岡 典子; 紫野 正人*; 坂倉 浩一*; 高安 幸弘*; 高橋 克昌*; 富永 英之*; 織内 昇*; et al.

British Journal of Cancer, 110(10), p.2506 - 2513, 2014/05

https://doi.org/10.1038/bjc.2014.178

Amino-acid transporters are necessary for the tumor cell growth and survival, and play a crucial role in the development of cancer. But, it remains unclear about the prognostic significance of L-type amino acid transporter 1 (LAT1), System ASC amino acid transporter 2 (ASCT2) and xCT expression in patients with tongue cancer. We conducted the clinicopathological study to investigate the protein expression of these amino acid transporters in tongue cancer. Eighty-five patients with surgically resected tongue cancer were evaluated. Tumor sections were stained by immunohistochemistry for LAT1, ASCT2, xCT, CD98, Ki-67, CD34 and p53. The expression of LAT1 and ASCT2 was significantly associated with disease staging, lymph node metastasis, lymphatic permeation, vascular invasion, CD98 expression and cell proliferation (Ki-67). xCT expression indicated a significant association with advanced stage and tumor factor, correlated with CD98. By univariate analysis, both LAT1 and ASCT2 had a significant relationship with prognosis. Multivariate analysis confirmed that LAT1 were independent prognostic factors for predicting poor prognosis. These results suggest that LAT1 and ASCT2 can serve as a significant prognostic factor for predicting worse outcome after surgical treatment and may play an important role in the development and pathogenesis for tongue cancer.

Clinical significance of L-type amino acid transporter 1 expression as a prognostic marker and potential of new targeting therapy in biliary tract cancer

解良 恭一*; 須納瀬 豊*; 大島 康宏; 石岡 典子; 荒川 和久*; 小川 哲史*; 砂長 則明*; 清水 公裕*; 富永 英之*; 織内 昇*; et al.

BMC Cancer, 13, p.482_1 - 482_12, 2013/10

https://doi.org/10.1186/1471-2407-13-482

The expression of L-type amino acid transporter 1 (LAT1) has been described to play essential roles in tumor growth and survival. However, it remains unclear about the clinicopathological significance of LAT1 expression in biliary tract cancer. This study was conducted to determine clinical significance of LAT1 expression and investigate whether LAT1 could be a new therapeutic target for biliary tract cancer. A total of 139 consecutive patients with resected pathologic stage I-IV biliary tract adenocarcinoma were retrospectively reviewed. Tumor sections were stained by immunohistochemistry for LAT1, CD98, Ki-67, microvessel density determined by CD34 and p53. Further, anti-tumor activity of LAT inhibitor, 2-aminobicyclo-(2,2,1)-heptane-2-carboxylic acid (BCH) was investigated using cholangiocarcinoma cell line. The expression of LAT1 was recognized in 64% of total patients, and closely correlated with CD98 expression, lymphatic metastases, cell proliferation and angiogenesis, and was a significant indicator for predicting poor outcome after surgery. Experiments showed that BCH significantly suppressed the tumor growth and BCH yielded an additive therapeutic efficacy to gemcitabine and 5-FU. A cooperative high expression of LAT1 with CD98 is a promising pathological marker to predict the outcome in biliary tract adenocarcinoma. Inhibition of LAT1 may be an effective targeted therapy for this distressing disease.

OSF-1炉内管のHe-3ガススクリーン付仕切管の製作

菅野 勝; 小山 昇; 石井 忠彦; 中崎 長三郎; 荒瀬 功

JAERI-Tech 97-042, 53 Pages, 1997/09

JAERI-Tech-97-042.pdf:2.17MB

JMTRに設置してあるOSF-1炉内管内に装着してある仕切管のHe-3ガススクリーンが、使用寿命に到達のため平成8年9月に更新した。本報告書は、約5年間にわたって行った更新用仕切管に関する各種の検討、設計、製作及び現地更新工事についてまとめたものである。

Electrochemical calorimetry of DO electrolysis using a palladium cathode; An Undivided, open cell system

小山 昇*; 大坂 武男*; 波戸崎 修*; 倉沢 祐子*; 山本 信重*; 笠原 誠司*; 今井 祐子*; 大山 幸夫; 中村 知夫; 柴田 徳思*; et al.

Bulletin of the Chemical Society of Japan, 63(9), p.2659 - 2664, 1990/09

https://doi.org/10.1246/bcsj.63.2659

原研核融合炉物理研究室と東京農工大のチームとで行ってきた常温核融合研究の成果の一つとして、重水電解時における発生熱量の精密測定に関して農工大チームがおこなってきた結果の報告である。実験結果は、重水素ガスと酸素の再結合では説明のできない過剰熱を示したが、常温核融合に関連する中性子・ガンマ線・トリチウム・ヘリウムなどの生成を確認することはできなかった。

Development of fuel failure detection system for a high temperature gas cooled reactor

寺田 博海; 若山 直昭; 小畑 雅博; 飛田 勉; 露崎 典平; 後藤 一郎; 小山 昇; 桜庭 耕一; 横内 猪一郎; 吉田 広; et al.

IEEE Transactions on Nuclear Science, 34(1), p.567 - 570, 1987/01

https://doi.org/10.1109/TNS.1987.4337408

高温ガス炉用高感度燃料破損検出法の研究開発を行った。FFD開発試験においては、一つの照射キャプセルに被覆粒子燃料の健全および破損試料の両方を封入し、照射中に夫々の試料の一次系ヘリウムガスをサンプリングして、FFD実験システムに導いている。 実験では、健全および破損燃料に対するFFD系の応答およびFP放出挙動を測定し、比較検討した。特に燃料温度が1200C以上では、本FFD系は両燃料試料に対して夫々異なる計数応答を示し、破損の検出に見通しを得た。また、一次系ヘリウムガス中FPのガンマ線スペクトルの連続モニタも実施した。