Nanoscopic structural investigation of physically cross-linked nanogels formed from self-associating polymers

Sekine, Yurina; Endo, Hitoshi*; Iwase, Hiroki*; Takeda, Shigeo*; Mukai, Sadaatsu*; Fukazawa, Hiroshi; Littrell, K. C.*; Sasaki, Yoshihiro*; Akiyoshi, Kazunari*

Journal of Physical Chemistry B, 120(46), p.11996 - 12002, 2016/11

https://doi.org/10.1021/acs.jpcb.6b06795

The detailed structure of a nanogel formed by self-association of cholesterol-bearing pullulans (CHP) was determined by contrast variation small-angle neutron scattering. The decomposition of scattering intensities into partial scattering functions of each CHP nanogel component, i.e., pullulan, cholesterol, and the cross-term between the pullulan and the cholesterol allows us to investigate the internal structure of the nanogel. The effective spherical radius of the skeleton formed by pullulan chains was found to be about 8.1 nm. In the CHP nanogel, there are about 19 cross-linking points where a cross-linking point is formed by aggregation of trimer cholesterol molecules with the spatially inhomogeneous distribution of the mass fractal dimension of 2.6. The average radius of the partial chains can also be determined to be 1.7 nm. As the result, the complex structure of the nanogels is coherently revealed at the nanoscopical level.

Mass production results of superconducting cables for CS and EF coils of JT-60SA

Sugimoto, Masahiro*; Kosugi, Keizo*; Katayama, Kota*; Ii, Hideki*; Takagi, Akira*; Endo, Sakaru*; Shimizu, Hitoshi*; Tsubouchi, Hirokazu*; Kizu, Kaname; Yoshida, Kiyoshi

Proceedings of 24th International Cryogenic Engineering Conference (ICEC 24) and International Cryogenic Materials Conference 2012 (ICMC 2012) (CD-ROM), p.799 - 802, 2012/05

We have successfully manufactured all superconducting cables for CS and EF coils of JT-60SA. The low temperature performance of superconducting wires satisfied the specifications under sufficiently low deviations and high production yields. Ni-plated strands of EF cables having the larger sliding friction between strands than that of Cr-plated strands of CS cable caused difficulties on the cabling without any defects. Consequently, the newly developed cabling techniques with the original inspection apparatus significantly enhanced the manufacturability and were effective for guarantee of the quality.

Replacement technology for front acrylic panels of a large-sized glove box using bag-in / bag-out method

Sakuraba, Naotoshi; Numata, Masami; Komiya, Tomokazu; Ichise, Kenichi; Nishi, Masahiro; Tomita, Takeshi; Usami, Koji; Endo, Shinya; Miyata, Seiichi; Kurosawa, Tatsuya; et al.

JAEA-Technology 2009-071, 34 Pages, 2010/03

JAEA-Technology-2009-071.pdf:21.07MB

As a part of maintenance technology of a large-sized glove box for handling of TRU nuclides, we developed replacement technology for front acrylic panels using the bag-in/bag-out method and applied this technology to replace the deteriorated front acrylic panels at Waste Safety Testing Facility (WASTEF) in Nuclear Science Research Institute of Japan Atomic Energy Agency (JAEA). As a consequence, we could safely replace the front acrylic panels under the condition of continuous negative pressure only with partial decontamination of the glove box. We also demonstrated that the present technology is highly effective in points of safety, workability and cost as compared to the usual replacement technology for front acrylic panels of a glove box, where workers in an air-line suit replace directly the front acrylic panels in a green house.

Microdosimetric study for secondary neutrons in phantom produced by a 290 MeV/nucleon carbon beam

Endo, Satoru*; Tanaka, Kenichi*; Takada, Masashi*; Onizuka, Yoshihiko*; Miyahara, Nobuyuki*; Sato, Tatsuhiko; Ishikawa, Masayoshi*; Maeda, Naoko*; Hayabuchi, Naofumi*; Shizuma, Kiyoshi*; et al.

Medical Physics, 34(9), p.3571 - 3578, 2007/09

https://doi.org/10.1118/1.2767933

Absorbed doses from main charged particle beams and charged-particle fragments have been measured with high accuracy for particle therapy but there are few reports for doses from neutron components produced as fragments. This study describes measurements on neutron dose produced by carbon beam, microdosimetric distributions of secondary neutrons produced by 290 MeV/nucleon carbon beams have been measured by using a tissue equivalent proportional counter (TEPC) at the Heavy Ion Medical Accelerator in Chiba (HIMAC) at the National Institute of Radiological Sciences (NIRS). The ratios of neutrons to charged particle fragments dominated to be 11 to 89 % in the absorbed doses at the side and below the faces of the acrylic phantom (300 mm height 300 mm width 253 mm thickness).

Failure patterns of high-grade glioma treated with BNCT

Matsuda, Masahide*; Yamamoto, Tetsuya*; Nakai, Kei*; Endo, Kiyoshi*; Kumada, Hiroaki; Kageji, Teruyoshi*; Matsumura, Akira*

Proceedings of 12th International Congress on Neutron Capture Therapy (ICNCT-12), p.40 - 42, 2006/10

To describe the failure patterns and survival seen with high-grade glioma treated with BNCT, the dose distribution and the clinical responses were retrospectively analyzed. BSH-based BNCT was performed in 12 patients with high-grade glioma (grade IV 7, grade III 5). The post-diagnosis median survival time of 12 patients was 19.8 months (range 3.3-47.2). Four cases of local control, 3 of local recurrence, 3 of distant intraparenchymal recurrence and 2 of subarachnoid dissemination were recorded. According to the analysis of the failure patterns, minimum GTV dose of 26 GyEq or more is necessary for local control.

Current clinical results of the Tsukuba BNCT trial

Yamamoto, Tetsuya*; Matsumura, Akira*; Nakai, Kei*; Shibata, Yasushi*; Endo, Kiyoshi*; Sakurai, Fumio; Kishi, Toshiaki; Kumada, Hiroaki; Yamamoto, Kazuyoshi; Torii, Yoshiya

Applied Radiation and Isotopes, 61(5), p.1089 - 1093, 2004/11

https://doi.org/10.1016/j.apradiso.2004.05.010

no abstracts in English

Analysis of intracellular distribution of boron and gadolinium in 9L sarcoma cells using a single-ended accelerator (Micro PIXE)

Endo, Kiyoshi*; Shibata, Yasushi*; Yoshida, Fumiyo*; Nakai, Kei*; Yamamoto, Tetsuya*; Matsumura, Akira*; Ishii, Keizo*; Sakai, Takuro; Sato, Takahiro; Oikawa, Masakazu*; et al.

Proceedings of 11th World Congress on Neutron Capture Therapy (ISNCT-11) (CD-ROM), 2 Pages, 2004/10

Micro PIXE, which is installed in a single end accelerator in JAERI, was used for quantitative analysis of boron and gadolinium distribution in a cell level. The micro beam of 1 m diameter is possible to observe the distribution. In the adjustment procedure of the sample, first is a fix of mylar film by using a glass ring and a bite ring of 2cm diameter. Next the 9L cells were scattered on the washed film, and is cultivated on 37C in medium until they form the mono-layer. After the Gd-BOPTA was added, it incubates for the 24-72 hour on 37C. The film is washed in the THAM liquid, and is directly put on liquid nitrogen. A vacuum drying for 24 hours is conducted in order to fix a film on holder. It is important to uniformly fix the cell in distribution analysis in the cell using Micro PIXE. In recent result, it became possible that the distribution of P, S, Gd, etc. was analyzed. But we could not distinguish whether K and Gd exist in the cell or whether it exists around the cell. It was indicated that these elements was leaked by the reason of cell breaking or other on the cytoplasm.

Intraoperative boron neutron capture therapy using thermal/epithermal mixed beam

Matsumura, Akira*; Yamamoto, Tetsuya*; Shibata, Yasushi*; Nakai, Kei*; Zhang, T.*; Matsushita, Akira*; Takano, Shingo*; Endo, Kiyoshi*; Akutsu, Hiroyoshi*; Yamamoto, Kazuyoshi; et al.

Research and Development in Neutron Capture Therapy, p.1073 - 1078, 2002/09

Since 1998 to 2002, a new clinical trial of an intraoperative boron neutron capture therapy (IOBNCT) at JRR-4 of Japan Atomic Energy Institute (JAERI) using BSH with mixed thermal/epithermal neutron beam has been accomplished. There have been 9 patients included in this study. The median survival time (MST) in GBM was 19.8 months and 16.8 months in AA. IOBNCT with mixed thermal/epithermal neutron beam provide better primary radiation effect than conventional therapy in selected cases. Our phase I/II clinical trial was effective in local tumor control. Further clinical trial with new design should be performed to prove the efficacy of IOBNCT.

Comparison of patient brain dose measurements and the JCDS calculation

Yamamoto, Tetsuya*; Matsumura, Akira*; Yamamoto, Kazuyoshi; Kumada, Hiroaki; Torii, Yoshiya; Endo, Kiyoshi*; Matsushita, Akira*; Shibata, Yasushi*; Nose, Tadao*

Research and Development in Neutron Capture Therapy, p.415 - 418, 2002/09

Dose measurements in a patient's brain undergoing intraoperative BNCT (IOBNCT) were compared with calculations by a JAERI computational dosimetry system (JCDS). The maximum thermal neutron flux on the brain surface from the postirradiation measurement averaged 2.330.37(10cms) and the vascular boron dose averaged 11.41.2 (9.6-12.7) Gy. Using JCDS, the maximum thermal neutron flux in the irradiated volume averaged 2.210.33(10cms), while the target vascular dose averaged 5.7 Gy and varied from 3.5 to 7.8 Gy. As such, in the dose planning for intra-operative irradiation, practical use of JCDS is recommended for uniform volume-dose control of postsurgical brain in IOBNCT.

Development of the fabrication technology for the superconducting coils in the ITER magnet system and its achievements

Hamada, Kazuya; Nakajima, Hideo; Okuno, Kiyoshi; Endo, Sakaru*; Kikuchi, Kenichi*; Kubo, Yoshio*; Aoki, Nobuo*; Yamada, Yuichi*; Osaki, Osamu*; Sasaki, Takashi*; et al.

JAERI-Tech 2002-027, 23 Pages, 2002/03

JAERI-Tech-2002-027.pdf:2.94MB

The Engineering Design Activities (EDA) for the International Thermonuclear Experimental Reactor (ITER) was performed under the collaboration of Japan, EU, Russia and the US. The EDA was successfully completed in July 2001, in which the development of fabrication technology for advanced components, such as superconducting coils, was conducted. The ITER magnet system consists of Toroidal Field coils, a Central Solenoid (CS), Poloidal Field coils and Correction coils. The construction of these coils requires advanced technologies that fairly exceeded those available at the start of the EDA. Therefore, CS Model Coil and TF Model Coil projects were implemented. To fabricate the CS Model Coil, the fabrication technologies for high performance strand, large cable, winding, heat treatment, joint and insulation are indispensable. This report describes the above detailed fabrication technologies successfully developed in the CS Model Coil Project.