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Journal Articles

Production of highly purified no-carrier-added $$^{177}$$Lu for radioimmunotherapy

Watanabe, Satoshi; Hashimoto, Kazuyuki; Watanabe, Shigeki; Iida, Yasuhiko*; Hanaoka, Hirofumi*; Endo, Keigo*; Ishioka, Noriko

Journal of Radioanalytical and Nuclear Chemistry, 303(1), p.935 - 940, 2015/01

 Times Cited Count:7 Percentile:60.95(Chemistry, Analytical)

Journal Articles

Development of a $$^{76}$$Br-labeled amino acid derivative for PET imaging of tumor

Hanaoka, Hirofumi*; Watanabe, Shigeki; Tominaga, Hideyuki*; Ohshima, Yasuhiro; Watanabe, Satoshi; Yamada, Keiichi*; Iida, Yasuhiko*; Ishioka, Noriko; Endo, Keigo*

JAEA-Review 2012-046, JAEA Takasaki Annual Report 2011, P. 89, 2013/01

no abstracts in English

Journal Articles

Production of radioactive bromine $$^{76}$$Br

Watanabe, Satoshi; Watanabe, Shigeki; Iida, Yasuhiko*; Hanaoka, Hirofumi*; Endo, Keigo*; Ishioka, Noriko

JAEA-Review 2011-043, JAEA Takasaki Annual Report 2010, P. 92, 2012/01

no abstracts in English

Journal Articles

Imaging and biodistribution of Her2/neu expression in non-small cell lung cancer xenografts with $$^{64}$$Cu -labeled trastuzumab PET

Paudyal, P.*; Paudyal, B.*; Hanaoka, Hirofumi*; Oriuchi, Noboru*; Iida, Yasuhiko*; Yoshioka, Hiroki*; Tominaga, Hideyuki*; Watanabe, Satoshi; Watanabe, Shigeki; Ishioka, Noriko; et al.

JAEA-Review 2010-065, JAEA Takasaki Annual Report 2009, P. 108, 2011/01

Journal Articles

PET studies of neuroendcrine tumors by using $$^{76}$$Br-$$m$$-bromobenzylguanidine ($$^{76}$$Br-MBBG)

Watanabe, Shigeki; Hanaoka, Hirofumi*; Liang, J. X.*; Iida, Yasuhiko*; Watanabe, Satoshi; Endo, Keigo*; Ishioka, Noriko

JAEA-Review 2010-065, JAEA Takasaki Annual Report 2009, P. 107, 2011/01

Journal Articles

PET imaging of norepinephrine transporter-expressing tumors using $$^{76}$$Br-${it meta}$-bromobenzylguanidine

Watanabe, Shigeki; Hanaoka, Hirofumi*; Liang, J. X.; Iida, Yasuhiko*; Endo, Keigo*; Ishioka, Noriko

Journal of Nuclear Medicine, 51(9), p.1472 - 1479, 2010/09

 Times Cited Count:18 Percentile:54.22(Radiology, Nuclear Medicine & Medical Imaging)

Journal Articles

Imaging and biodistribution of Her2/neu expression in non-small cell lung cancer xenografts with $$^{64}$$Cu-labeled trastuzumab PET

Paudyal, P.*; Paudyal, B.*; Hanaoka, Hirofumi*; Oriuchi, Noboru*; Iida, Yasuhiko*; Yoshioka, Hiroki*; Tominaga, Hideyuki*; Watanabe, Satoshi; Watanabe, Shigeki; Ishioka, Noriko; et al.

Cancer Science, 101(4), p.1045 - 1050, 2010/04

 Times Cited Count:34 Percentile:67.02(Oncology)

Journal Articles

Production of Lu-177 capable of labeling antibodies

Watanabe, Satoshi; Hashimoto, Kazuyuki; Watanabe, Shigeki; Iida, Yasuhiko*; Hanaoka, Hirofumi*; Endo, Keigo*; Ishioka, Noriko

JAEA-Review 2009-041, JAEA Takasaki Annual Report 2008, P. 109, 2009/12

no abstracts in English

Journal Articles

Production of radioisotopes for nuclear medicine using ion-beam technology and its utilization for both therapeutic and diagnostic application in cancer

Iida, Yasuhiko*; Hanaoka, Hirofumi*; Watanabe, Satoshi; Watanabe, Shigeki; Ishioka, Noriko; Yoshioka, Hiroki*; Yamamoto, Shinji*; Paudyal, P.*; Paudyal, B.*; Higuchi, Tetsuya*; et al.

JAEA-Review 2009-041, JAEA Takasaki Annual Report 2008, P. 108, 2009/12

Journal Articles

$$^{76}$$Br-m-bromobenzylguanidine ($$^{76}$$Br-MBBG) for in vivo imaging of neuroendcrine-tumor with PET

Watanabe, Shigeki; Hanaoka, Hirofumi*; Liang, J. X.; Iida, Yasuhiko*; Watanabe, Satoshi; Endo, Keigo*; Ishioka, Noriko

JAEA-Review 2009-041, JAEA Takasaki Annual Report 2008, P. 107, 2009/12

Journal Articles

Evaluation of $$^{64}$$Cu-labeled DOTA-$$_{rm D}$$-Phe$$^{1}$$-Tyr$$^{3}$$-octreotide ($$^{64}$$Cu-DOTA-TOC) for imaging somatostatin receptor-expressing tumors

Hanaoka, Hirofumi*; Tominaga, Hideyuki*; Yamada, Keiichi*; Paudyal, P.*; Iida, Yasuhiko*; Watanabe, Shigeki; Paudyal, B.*; Higuchi, Tetsuya*; Oriuchi, Noboru*; Endo, Keigo*

Annals of Nuclear Medicine, 23(6), p.559 - 567, 2009/08

 Times Cited Count:16 Percentile:49.88(Radiology, Nuclear Medicine & Medical Imaging)

Journal Articles

Production of no-carrier-added $$^{64}$$Cu and applications to molecular imaging by PET and PETIS as a biomedical tracer

Watanabe, Shigeki; Iida, Yasuhiko*; Suzui, Nobuo; Katabuchi, Tatsuya*; Ishii, Satomi; Kawachi, Naoki; Hanaoka, Hirofumi*; Watanabe, Satoshi; Matsuhashi, Shimpei; Endo, Keigo*; et al.

Journal of Radioanalytical and Nuclear Chemistry, 280(1), p.199 - 205, 2009/04

 Times Cited Count:18 Percentile:78.17(Chemistry, Analytical)

Journal Articles

Nano-particle materials prepared from a synthetic antigenic sequence of ${it plasmodium falciparum}$ enolase

Oku, Hiroyuki*; Yamada, Keiichi*; Kobayashi, Kyoko*; Katakai, Ryoichi*; Ashfaq, M.*; Hanaoka, Hirofumi*; Iida, Yasuhiko*; Endo, Keigo*; Hasegawa, Shin; Maekawa, Yasunari; et al.

Peptide Science 2008, p.439 - 442, 2009/03

Malaria is the major cause of mortality and morbidity in the tropical and subtropical regions in the world. Our previous studies have shown that a series of partial peptides of a Plasmodium falciparum enolase have antigenic reactivity against patients' sera. In this paper, we wish to report nano-encapsulation of a synthetic antigen into bioabsorbable polymer particles and their releasing studies in vitro and in vivo.

Journal Articles

Production of radioisotopes for nuclear medicine using ion-beam technology and its utilization for both therapeutic and diagnostic application in cancer

Iida, Yasuhiko*; Hanaoka, Hirofumi*; Paudyal, P.*; Paudyal, B.*; Watanabe, Satoshi; Ishioka, Noriko; Watanabe, Shigeki; Matsuhashi, Shimpei; Yoshioka, Hiroki*; Higuchi, Tetsuya*; et al.

JAEA-Review 2008-055, JAEA Takasaki Annual Report 2007, P. 114, 2008/11

Journal Articles

Production of $$^{67}$$Cu via the $$^{68}$$Zn(p,2p) $$^{67}$$Cu reaction and recovery of $$^{68}$$Zn target

Katabuchi, Tatsuya*; Watanabe, Satoshi; Ishioka, Noriko; Iida, Yasuhiko*; Hanaoka, Hirofumi*; Endo, Keigo*; Matsuhashi, Shimpei

Journal of Radioanalytical and Nuclear Chemistry, 277(2), p.467 - 470, 2008/08

 Times Cited Count:27 Percentile:86.74(Chemistry, Analytical)

Journal Articles

Production of radioisotopes for nuclear medicine using ion-beam technology and its utilization for both therapeutic and diagnostic application in cancer

Iida, Yasuhiko*; Hanaoka, Hirofumi*; Katabuchi, Tatsuya*; Watanabe, Shigeki; Ishioka, Noriko; Watanabe, Satoshi; Matsuhashi, Shimpei; Higuchi, Tetsuya*; Oriuchi, Noboru*; Endo, Keigo*

JAEA-Review 2007-060, JAEA Takasaki Annual Report 2006, P. 128, 2008/03

Journal Articles

Production of radioisotopes for nuclear medical application

Katabuchi, Tatsuya*; Watanabe, Satoshi; Ishioka, Noriko; Matsuhashi, Shimpei; Iida, Yasuhiko*; Hanaoka, Hirofumi*; Endo, Keigo*

JAEA-Review 2006-042, JAEA Takasaki Annual Report 2005, P. 132, 2007/02

no abstracts in English

Journal Articles

Production of radioisotopes for nuclear medicine using ion beam technology and its utilization for both therapeutic and diagnostic application in cancer

Iida, Yasuhiko*; Hanaoka, Hirofumi*; Katabuchi, Tatsuya*; Watanabe, Satoshi; Ishioka, Noriko; Matsuhashi, Shimpei; Oriuchi, Noboru*; Higuchi, Tetsuya*; Miyakubo, Mitsuyuki*; Endo, Keigo*

JAEA-Review 2006-042, JAEA Takasaki Annual Report 2005, P. 165, 2007/02

Journal Articles

Design, synthesis, and evaluation of [$$^{188}$$Re]Organorhenium-labeled antibody fragments with renal enzyme-cleavable linkage for low renal radioactivity levels

Uehara, Tomoya*; Koike, Miho*; Nakata, Hideo*; Hanaoka, Hirofumi*; Iida, Yasuhiko*; Hashimoto, Kazuyuki; Akizawa, Hiromichi*; Endo, Keigo*; Arano, Yasushi*

Bioconjugate Chemistry, 18(1), p.190 - 198, 2007/01

 Times Cited Count:15 Percentile:50.52(Biochemical Research Methods)

Renal localization of radiolabeled antibody fragments constitutes a problem in targeted imaging and radiotherapy. To estimate the applicability of the molecular design to metallic radionuclides, [$$^{188}$$Re]tricarbonyl(cyclopentadienylcarbonate)rhenium ([$$^{188}$$Re]CpTR-COOH) was conjugated with maleoyl-glycyl-lysine to prepare [$$^{188}$$Re]CpTR-GK. The cleavage of the glycyl-lysine linkage of the compound generates a glycine conjugate of [$$^{188}$$Re]CpTR-Gly. [$$^{188}$$Re]CpTR-GK was conjugated to thiolated Fab fragments to prepare [$$^{188}$$Re]CpTR-GK-Fab. The biodistribution of radioactivity after injection of [$$^{188}$$Re]CpTR-GK-Fab was compared with that of [$$^{188}$$Re]CpTR-Fab. [$$^{188}$$Re]CpTR-GK-Fab exhibited significantly lower renal radioactivity levels than did [$$^{188}$$Re]CpTR-Fab. The analysis of urine samples collected for 6 h postinjection of [$$^{188}$$Re]CpTR-GK-Fab showed that [$$^{188}$$Re]CpTR-Gly was the major radiometabolite. In tumor-bearing mice, [$$^{188}$$Re]CpTR-GK-Fab significantly reduced renal radioactivity levels without impairing the radioactivity levels in tumor. These findings indicate that the molecular design of radioparmaceuticals labeled with metallic radionuclides can be useful by using a radiometal chelate of high inertness and by designing a radiometabolite of high urinary excretion when released from antibody fragments following cleavage of a glycyl-lysine linkage. This study also indicates that a change in chemical structure of a radiolabel attached to a glycyl-lysine linkage significantly affected enzymes involved in the hydrolysis reaction.

JAEA Reports

2nd power-up test for JRR-2

Kambara, Toyozo; Uno, Hidero; Shoda, Katsuhiko; Hirata, Yutaka; Shoji, Tsutomu; Kohayakawa, Toru; Takayanagi, Hiroshi; Fujimura, Tsutomu; Morita, Morito; Ichihara, Masahiro; et al.

JAERI 1045, 11 Pages, 1963/03

JAERI-1045.pdf:0.72MB

no abstracts in English

71 (Records 1-20 displayed on this page)