• help
  • PC | SP
  • JP | EN
          
検索対象：     
報告書番号：
※ 半角英数字
 年 ～ 
 年
全てクリア
前の画面に戻る

Synthesis and stability of [$$^{77}$$Br]-m-Bromobenzylguanidine ($$^{77}$$Br-MBBG)

[$$^{77}$$Br]-m-Bromobenzylguanidine($$^{77}$$Br-MBBG)の合成と安定性

渡邉 茂樹; 石岡 典子; Liang, J. X.; 花岡 宏史*; 飯田 靖彦*; 遠藤 啓吾*

Watanabe, Shigeki; Ishioka, Noriko; Liang, J. X.; Hanaoka, Hirofumi*; Iida, Yasuhiko*; Endo, Keigo*

$$^{76}$$Br (t$$_{1/2}$$ = 16.2 h, $$beta$$$$^{+}$$ = 57%, EC = 43%) has intermediated half-life and may have great potentials as radionuclide for positron emission tomography (PET). We have produced $$^{76}$$Br via the $$^{76}$$Se(p,n)$$^{76}$$Br reaction using Cu$$_{2}$$$$^{76}$$Se target by AVF cyclotron in JAEA, and also have interest in bromine labeled radiopharmaceuticals. Radioiodine labeled m-iodobenzylguanidine (MIBG) such as [$$^{123}$$I]-MIBG have been widely employed for heart function and tumor imaging with SPECT. In contrast, PET is superior in quantitative measurement and $$^{76}$$Br labeled bromobenzylguanidine (MBBG) can be expected to employ as a novel imaging reagent with PET. In this work, we synthesized radioactive Br labeled MBBG using $$^{77}$$Br and evaluated the chemical properties and stability of Br-MBBG.

使用言語

 :

English

掲載資料名

 :

巻

 :

号

 :

ページ数

 :

発行年月

 :

発表会議名

 :

6th International Symposium on Radiohalogens

開催年月

 :

2008/09

開催都市

 :

Whistler

開催国

 :

Canada

キーワード

 :

no keyword

特許データ

 :

PDF

 :


論文URL

 :

研究データの公開先DOI

 :

使用施設

 :

TIARA(イオン照射研究施設)

広報プレスリリース

 :

論文解説記事
(成果普及情報誌)

 :

受委託・共同研究相手機関

 :

群馬大学

Access

 :

- Accesses

InCites™

 :

Altmetrics

 :

[CLARIVATE ANALYTICS], [WEB OF SCIENCE], [HIGHLY CITED PAPER & CUP LOGO] and [HOT PAPER & FIRE LOGO] are trademarks of Clarivate Analytics, and/or its affiliated company or companies, and used herein by permission and/or license.

前の画面に戻る