• help
  • PC | SP
  • JP | EN
          
検索対象：     
報告書番号：
※ 半角英数字
 年 ～ 
 年
全てクリア
前の画面に戻る

Synthesis and stability of $$^{76}$$Br-${it m}$-bromobenzylgianidine ($$^{76}$$Br-MBBG)

$$^{76}$$Br-${it m}$-ブロモベンジルグアニジン($$^{76}$$Br-MBBG)の合成と安定性

渡邉 茂樹; 花岡 宏史*; Liang, J. X.; 飯田 靖彦*; 遠藤 啓吾*; 石岡 典子

Watanabe, Shigeki; Hanaoka, Hirofumi*; Liang, J. X.; Iida, Yasuhiko*; Endo, Keigo*; Ishioka, Noriko

$$^{76}$$Br (t$$_{1/2}$$ = 16.2 h, $$beta$$$$^{+}$$ = 57%, EC = 43%) has intermediated half-life and may have great potentials as radionuclide for positron emission tomography (PET). We have produced $$^{76}$$Br via the $$^{76}$$Se(p,n)$$^{76}$$Br reaction using Cu$$_{2}$$$$^{76}$$Se target, and also have interest in bromine labeled radiopharmaceuticals. Radioiodine labeled ${it m}$-iodobenzylguanidine (MIBG) such as [$$^{123}$$I] or [$$^{131}$$I]-MIBG have been widely employed for imaging of myocardial function and neuroendcrine tumor with single photon emission computed tomography (SPECT). PET is superior in quantitative measurement to SPECT, thus positron emitter $$^{76}$$Br-labeled MIBG can be expected to employ as a novel imaging reagent for PET. In this study, we synthesized $$^{76}$$Br labeled meta-bromobenzylguanidine ($$^{76}$$Br-MBBG) for tumor imaging by PET to evaluated stability in serum and biodistribution of $$^{76}$$Br-MBBG using normal mice.

使用言語

 :

English

掲載資料名

 :

巻

 :

号

 :

ページ数

 :

発行年月

 :

発表会議名

 :

4th International COE Symposium on Biomedical Research Using Accelerator Technology

開催年月

 :

2008/11

開催都市

 :

Maebashi

開催国

 :

Japan

キーワード

 :

no keyword

特許データ

 :

PDF

 :


論文URL

 :

研究データの公開先DOI

 :

使用施設

 :

TIARA(イオン照射研究施設)

広報プレスリリース

 :

論文解説記事
(成果普及情報誌)

 :

受委託・共同研究相手機関

 :

群馬大学

Access

 :

- Accesses

InCites™

 :

Altmetrics

 :

[CLARIVATE ANALYTICS], [WEB OF SCIENCE], [HIGHLY CITED PAPER & CUP LOGO] and [HOT PAPER & FIRE LOGO] are trademarks of Clarivate Analytics, and/or its affiliated company or companies, and used herein by permission and/or license.

前の画面に戻る