Production of no-carrier-added Cu and applications to molecular imaging by PET and PETIS as a biomedical tracer

無担体Cuの製造及びバイオメディカルトレーサとしてのPET及びPETISによる分子イメージングへの応用

渡邉 茂樹; 飯田 靖彦*; 鈴井 伸郎; 片渕 竜也*; 石井 里美; 河地 有木; 花岡 宏史*; 渡辺 智; 松橋 信平; 遠藤 啓吾*; 石岡 典子

Watanabe, Shigeki; Iida, Yasuhiko*; Suzui, Nobuo; Katabuchi, Tatsuya*; Ishii, Satomi; Kawachi, Naoki; Hanaoka, Hirofumi*; Watanabe, Satoshi; Matsuhashi, Shimpei; Endo, Keigo*; Ishioka, Noriko

Copper-64 was produced by the Ni(p,n)Cu reaction using enriched-NiO target. We investigated and compared the production yield of Cu for proton beams of various energies by using a thick target. Enriched-Ni was recovered with high yield by simple procedures. Imaging studies using positron emission tomography (PET) and positron emitting tracer imaging system (PETIS) were performed. We obtained clear images in PET and PETIS studies. The results of this study indicate that Cu can be utilized as a biomedical tracer for the molecular imaging both in animals and plants.