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Yamazaki, Satoshi*; Hirose, Kiyoshige*; Sasaki, Hirokazu*; Oba, Yojiro; Miyazawa, Tomotaka*; Onuma, Masato*
Do To Dogokin, 60(1), p.315 - 319, 2021/08
no abstracts in English
Kawasaki, Riku*; Sasaki, Yoshihiro*; Nishimura, Tomoki*; Katagiri, Kiyofumi*; Morita, Keiichi*; Sekine, Yurina; Sawada, Shinichi*; Mukai, Sadaatsu*; Akiyoshi, Kazunari*
Advanced Healthcare Materials, 10(9), p.2001988_1 - 2001988_8, 2021/05
Times Cited Count：8 Percentile：60(Engineering, Biomedical)Systems for "protein transduction", the intracellular delivery of functional proteins, are needed to address the deliverability challenges of protein therapy, but protein transfer in vivo remains difficult. In this study, we have developed a magnetically induced in vivo protein transfection system using a magnetic nanogel chaperone (MC) composed of iron oxide nanoparticles and polysaccharide nanogels. Experiments using an oral cancer model have shown that this MC system is useful for cancer treatment.
Sasaki, Hirokazu*; Nishikubo, Hideo*; Nishida, Shinsuke*; Yamazaki, Satoshi*; Nakasaki, Ryusuke*; Isomatsu, Takemi*; Minato, Ryuichiro*; Kinugawa, Kohei*; Imamura, Akihiro*; Otomo, Shinya*; et al.
Furukawa Denko Jiho, (138), p.2 - 10, 2019/02
no abstracts in English
(3) sigma modelJimmenez, S.*; Oka, Makoto; Sasaki, Kiyoshi*
Physical Review D, 97(11), p.114506_1 - 114506_28, 2018/06
Times Cited Count：0 Percentile：0.01(Astronomy & Astrophysics)We nonperturbatively calculate the wave-function renormalization in the two-dimensional (3) sigma model. It is evaluated in a box with a finite spatial extent. We determine the anomalous dimension in the finite-volume scheme through an analysis of the step-scaling function. Results are compared with a perturbative evaluation, and reasonable behavior is observed.
Sekine, Yurina; Endo, Hitoshi*; Iwase, Hiroki*; Takeda, Shigeo*; Mukai, Sadaatsu*; Fukazawa, Hiroshi; Littrell, K. C.*; Sasaki, Yoshihiro*; Akiyoshi, Kazunari*
Journal of Physical Chemistry B, 120(46), p.11996 - 12002, 2016/11
Times Cited Count：10 Percentile：26.96(Chemistry, Physical)The detailed structure of a nanogel formed by self-association of cholesterol-bearing pullulans (CHP) was determined by contrast variation small-angle neutron scattering. The decomposition of scattering intensities into partial scattering functions of each CHP nanogel component, i.e., pullulan, cholesterol, and the cross-term between the pullulan and the cholesterol allows us to investigate the internal structure of the nanogel. The effective spherical radius of the skeleton formed by pullulan chains was found to be about 8.1 nm. In the CHP nanogel, there are about 19 cross-linking points where a cross-linking point is formed by aggregation of trimer cholesterol molecules with the spatially inhomogeneous distribution of the mass fractal dimension of 2.6. The average radius of the partial chains can also be determined to be 1.7 nm. As the result, the complex structure of the nanogels is coherently revealed at the nanoscopical level.
Yoshida, Masafumi; Hanada, Masaya; Kojima, Atsushi; Kashiwagi, Mieko; Grisham, L. R.*; Hatayama, Akiyoshi*; Shibata, Takanori*; Yamamoto, Takashi*; Akino, Noboru; Endo, Yasuei; et al.
Fusion Engineering and Design, 96-97, p.616 - 619, 2015/10
Times Cited Count：11 Percentile：67.3(Nuclear Science & Technology)In JT-60 Super Advanced for the fusion experiment, 22A, 100s negative ions are designed to be extracted from the world largest ion extraction area of 450 mm 
1100 mm. One of the key issues for producing such as high current beams is to improve non-uniform production of the negative ions. In order to improve the uniformity of the negative ions, a tent-shaped magnetic filter has newly been developed and tested for JT-60SA negative ion source. The original tent-shaped filter significantly improved the logitudunal uniformity of the extracted H
ion beams. The logitudinal uniform areas within a 
10 deviation of the beam intensity were improved from 45% to 70% of the ion extraction area. However, this improvement degrades a horizontal uniformity. For this, the uniform areas was no more than 55% of the total ion extraction area. In order to improve the horizontal uniformity, the filter strength has been reduced from 660 Gasus
cm to 400 Gasuscm. This reduction improved the horizontal uniform area from 75% to 90% without degrading the logitudinal uniformity. This resulted in the improvement of the uniform area from 45% of the total ion extraction areas. This improvement of the uniform area leads to the production of a 22A H ion beam from 450 mm 1100 mm with a small amount increase of electron current of 10%. The obtained beam current fulfills the requirement for JT-60SA.
spin-flip 
value in hypernucleiSasaki, Yuki*; Ekawa, Hiroyuki; Hasegawa, Shoichi; Hayakawa, Shuhei; Hosomi, Kenji; Ichikawa, Yudai; Imai, Kenichi; Sako, Hiroyuki; Sato, Susumu; Sugimura, Hitoshi; et al.
JPS Conference Proceedings (Internet), 8, p.022013_1 - 022013_4, 2015/09
Shinohara, Masanori; Motegi, Toshihiro; Saito, Kenji; Haga, Hiroyuki; Sasaki, Shinji; Katsuyama, Kozo; Takada, Kiyoshi*; Higashimura, Keisuke*; Fujii, Junichi*; Ukai, Takayuki*; et al.
JAEA-Technology 2012-032, 29 Pages, 2012/11
JAEA-Technology-2012-032.pdf:6.57MB
An event, in which one of WRMs were disabled to detect the neutron flux in the reactor core, occurred during the period of reactor shut down of HTTR in March, 2010. The actual life time of WRM was unexpectedly shorter than the past developed life time. Investigation of the cause of the outage of WRM toward the recovery of the life time up to the past developed life is one of the issues to develop the technology basis of HTGR. Then, two experimental investigations were carried out to reveal the cause of the malfunction by specifying the damaged part causing the event in the WRM. One is an experiment using a mock-up sample test which strength degradation on assembly accuracy and heat cycle to specify the damaged part in the WRM. The other is a destructive test in FMF to specify the damaged part in the WRM. This report summarized the results of the destructive test and the experimental investigation using the mock-up to reveal the cause of malfunction of WRM.
m band using focused proton beamMiura, Kenta*; Machida, Yuki*; Uehara, Masato*; Kiryu, Hiromu*; Ozawa, Yusuke*; Sasaki, Tomoyuki*; Hanaizumi, Osamu*; Sato, Takahiro; Ishii, Yasuyuki; Koka, Masashi; et al.
Key Engineering Materials, 497, p.147 - 150, 2012/00
Times Cited Count：7 Percentile：95.12(Engineering, Electrical & Electronic)m band using focused proton beamMiura, Kenta*; Machida, Yuki*; Uehara, Masato*; Kiryu, Hiromu*; Ozawa, Yusuke*; Sasaki, Tomoyuki*; Hanaizumi, Osamu*; Sato, Takahiro; Ishii, Yasuyuki; Koka, Masashi; et al.
Key Engineering Materials, 497, p.147 - 150, 2011/12
Times Cited Count：6 Percentile：2.48Nakagawa, Akinori; Sone, Tomoyuki; Sasaki, Toshiki; Nakazawa, Osamu; Tashiro, Kiyoshi
Proceedings of International Waste Management Symposia 2011 (WM2011) (CD-ROM), 7 Pages, 2011/03
Nakagawa, Akinori; Sone, Tomoyuki; Sasaki, Toshiki; Nakazawa, Osamu; Tashiro, Kiyoshi
JAEA-Technology 2010-014, 46 Pages, 2010/06
JAEA-Technology-2010-014.pdf:1.76MB
Steam reforming treatment system was developed for volume reduction of Tri-n-butyl phosphate contaminated with uranium, which is difficult to treat with incineration, due to generation of corrosive compounds, a large amount of secondary waste, etc. This system consists of a steam reforming process in which organic waste is decomposed/gasified in steam atmosphere and a submerged combustion process in which vaporized waste is burned in water and has good features such as high volume reduction rate of waste, low secondary waste generation rate, etc. Results obtained this study were as follows: Volume reduction rate of waste was 99.6%. Uranium entrainment to off-gas was suppressed and the concentration of uranium in waste water was under 0.037mg/L. The concentration of CO and NOx in the off-gas were less than 100ppm and 250ppm respectively. Plugging and corrosion control technologies were developed and it was confirmed that the waste treatment system can run for long periods.
Sone, Tomoyuki; Nakagawa, Akinori; Koyama, Hayato; Gunji, Kiyoshi; Nonaka, Kazuharu; Sasaki, Toshiki; Tashiro, Kiyoshi; Yamashita, Toshiyuki
JAEA-Technology 2009-023, 33 Pages, 2009/06
JAEA-Technology-2009-023.pdf:8.11MB
Steam reforming (SR) method consists of the gasification process in which organics are vaporized and decomposed with superheated steam and the oxidation process in which vaporized organics are decomposed by oxidizing reaction with heated air. 2,500L of waste TBP/n-dodecane contaminated with uranium was treated using the demonstration scale steam reforming system to examine the performance of the system. Results obtained in this study show that the temperature in the SR system was controlled under the self-regulation temperature, the concentration of CO and NOx in the off-gas were controlled less than 100ppm and 250ppm respectively, the distribution ratio of uranium to off-gas treatment system was under 0.12% and the gasification ratio of waste TBP was more than 99%. This long-term waste treatment test has demonstrated that the SR system can safely and effectively reduce the volume of the waste.
Chijimatsu, Masakazu*; Fukudome, Kazuto*; Urano, Kazuhiko*; Imai, Hisashi*; Sasaki, Hajime*; Amemiya, Kiyoshi*
JNC TJ8400 2004-027, 87 Pages, 2005/02
JNC-TJ8400-2004-027.pdf:2.13MB
This study investigates the methodology for the engineered barriers performance confirmation. First of all the investigation about the monitoring concept in foreign countries were performed and the monitoring aiming was fixed at the performance confirmation of the engineered barriers. The monitoring item and the element of engineered barriers were set as followings, namely temperature, hydraulic pressure, water contents, pH, Eh and the chemistry of solutions. The indirect measuring method of items both providing the engineered barriers performance and varying with exhibition of performance from the rock around the engineered barriers is proposed for the engineered barriers performance confirmation monitoring.
Hamada, Kazuya; Nakajima, Hideo; Okuno, Kiyoshi; Endo, Sakaru*; Kikuchi, Kenichi*; Kubo, Yoshio*; Aoki, Nobuo*; Yamada, Yuichi*; Osaki, Osamu*; Sasaki, Takashi*; et al.
JAERI-Tech 2002-027, 23 Pages, 2002/03
JAERI-Tech-2002-027.pdf:2.94MB
The Engineering Design Activities (EDA) for the International Thermonuclear Experimental Reactor (ITER) was performed under the collaboration of Japan, EU, Russia and the US. The EDA was successfully completed in July 2001, in which the development of fabrication technology for advanced components, such as superconducting coils, was conducted. The ITER magnet system consists of Toroidal Field coils, a Central Solenoid (CS), Poloidal Field coils and Correction coils. The construction of these coils requires advanced technologies that fairly exceeded those available at the start of the EDA. Therefore, CS Model Coil and TF Model Coil projects were implemented. To fabricate the CS Model Coil, the fabrication technologies for high performance strand, large cable, winding, heat treatment, joint and insulation are indispensable. This report describes the above detailed fabrication technologies successfully developed in the CS Model Coil Project.
Takebe, Shinichi; Kimura, Hideo; Matsuzuru, Hideo; Takahashi, Tomoyuki*; Yasuda, Hiroshi*; Uchida, Shigeo*; Mahara, Yasunori*; Saeki, Akiyoshi*; Sasaki, Noriyuki*; Ashikawa, Nobuo*; et al.
JAERI-Review 2001-015, 81 Pages, 2001/05
JAERI-Review-2001-015.pdf:5.94MB
no abstracts in English
Takahashi, Tomoyuki*; Takebe, Shinichi; Kimura, Hideo; Matsuzuru, Hideo; Yasuda, Hiroshi*; Uchida, Shigeo*; Saeki, Akiyoshi*; Mahara, Yasunori*; Sasaki, Noriyuki*; Ashikawa, Nobuo*; et al.
KURRI-KR-44, p.169 - 176, 2000/02
no abstracts in English
Oka, Kiyoshi; Tada, Eisuke; Kimura, Seiichiro*; Ogawa, Tadashi*; Sasaki, Nami*
High-power Lasers in Manufacturing (Proceedings of SPIE Vol.3888), p.702 - 709, 1999/11
no abstracts in English
Takahashi, Tomoyuki; Takebe, Shinichi; Kimura, Hideo; Matsuzuru, Hideo; Yasuda, Hiroshi*; Uchida, Shigeo*; Saeki, Akiyoshi*; Mahara, Yasunori*; Sasaki, Noriyuki*; *; et al.
JAERI-Research 97-089, 25 Pages, 1997/12
JAERI-Research-97-089.pdf:1.11MB
no abstracts in English
Takahashi, Tomoyuki; Takebe, Shinichi; Kimura, Hideo; Matsuzuru, Hideo; Yasuda, Hiroshi*; Uchida, Shigeo*; Saeki, Akiyoshi*; Mahara, Yasunori*; Sasaki, Noriyuki*; Yajima, Tatsuya*; et al.
JAERI-Research 97-066, 34 Pages, 1997/10
JAERI-Research-97-066.pdf:1.5MB
no abstracts in English
