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スピントラップ剤CYPMPOのスピンアダクト生成・減衰挙動

Detection and quantification of the spin adduct produced from CYPMPO and water decomposition radicals

岡 壽崇; 山下 真一; 翠川 匡道*; 佐伯 誠一; 室屋 裕佐*; Lin, M.; 上林 將人*; 安西 和紀*; 工藤 久明*; 勝村 庸介

Oka, Toshitaka; Yamashita, Shinichi; Midorikawa, Masamichi*; Saiki, Seiichi; Muroya, Yusa*; Lin, M.; Kamibayashi, Masato*; Anzai, Kazunori*; Kudo, Hisaaki*; Katsumura, Yosuke

スピントラップ剤CYPMPOと水分解ラジカル(OH$$cdot$$, O$$_{2}$$$$cdot$$$$^{-}$$等)との反応性を調べた。$$^{60}$$Co$$gamma$$線照射CYPMPO水溶液の紫外可視吸収スペクトルの結果から,200$$sim$$300nmにCYPMPOとラジカルとの反応によって生成するスピンアダクト生成物が確認され、その寿命は1時間以上であることがわかった。さらに、ESR測定と合わせ、スピンアダクトの生成と減衰挙動を検討した。

Detection and quantification of the oxidative radicals such as hydroxyl radical or superoxide anion radical are very important to clarify the biological oxidative damages. These oxidative radicals, produced by water decomposition with $$gamma$$-ray irradiation, were detected as spin adducts of CYPMPO and themselves. In this work, reactivity CYPMPO and behavior of spin adducts were investigated.

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