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ヒドロキシプロピルセルロースを母材とするゲル線量計の開発; $$gamma$$線照射での白濁化に対する検出剤組成の影響

Development of polymer gel dosimeter based on hydroxypropycellulose hydrogel; Effects of solute compositions on dose response for $$gamma$$-irradiations in terms of turbidity

山下 真一; 廣木 章博; 長澤 尚胤; 田口 光正

Yamashita, Shinichi; Hiroki, Akihiro; Nagasawa, Naotsugu; Taguchi, Mitsumasa

電子線照射により橋かけしたヒドロキシプロピルセルロースをゲル母材とすることで、毒性が低く環境にもやさしい高分子ゲル線量計を開発した。がん治療での実用的な線量範囲(0-10Gy程度)において$$^{60}$$Co $$gamma$$線照射に伴う白濁化が確認され、検出剤組成により白濁しやすさが変わり、これにより感度を制御できる可能性が示された。さらに、紫外可視分光光度計を用いて吸光度(透過度)の線量に対する変化を調べたところ、観測波長により挙動は異なり、300-500nmの短波長領域では長波長領域(500-800nm)と異なる挙動が観測され、4Gy程度でミクロゲルによる散乱に対応すると思われるピークが300-400nm付近に出現することがわかった。このピークは照射とともに長波長側に100nm程度シフトすることもわかった。

Polymer gel dosimeters based on hydroxypropylcellulose (HPC) hydrogel crosslinked by an irradiation of 2-MeV electron beam have been developed. Gel properties of the radiation-crosslinked HPC hydrogel were estimated with varying HPC concentration, absorbed dose, and type of radiation. Such hydrogel was utilized as gel matrix for polymer gel dosimeters which are more environment-friendly and easily handled than "toxic" polymer gel dosimeters composed of methacrylic acid or acrylamide. In the present study, solutes of the gel dosimeters were 2-hydroxyethyl-methacrylate (HEMA), polyethylene glycol dimethacrylate (PEG), and tetrakis hydroxyphosphonium chloride (THPC). Ratio of the concentrations of the solutes was varied to investigate sensitivity from the viewpoint of absorbance in a UV-vis region. As a result, absorbance increase in shorter-wavelength region (i.e. 300-500 nm) was different from that in longer-wavelength region. It was found that a peak appears in 300-400 nm with about 4-Gy irradiation, which is thought to be corresponding to productions of microgels, and that this peak slightly shift to longer wavelength with further irradiation.

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