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Performance of the first Japanese large-scale facility for radon inhalation experiments with small animals

小動物用ラドン吸入実験に向けた日本初の大規模施設の性能

石森 有; 光延 文裕*; 山岡 聖典*; 田中 裕史; 片岡 隆浩*; 迫田 晃弘*

Ishimori, Yuu; Mitsunobu, Fumihiro*; Yamaoka, Kiyonori*; Tanaka, Hiroshi; Kataoka, Takahiro*; Sakoda, Akihiro*

さまざまなラドン環境での生物学的応答の相違に関する統計的妥当性を高めるために、小動物用のラドン試験施設を開発した。本論文では、その日本で最初の大規模施設の性能を示す。この施設では、一度におよそマウス150匹規模の試験が可能である。小動物のラドン曝露装置はそれぞれ5つの独立したケージを備えた6つの動物チャンバー群を有している。動物チャンバー群ごとに異なるラドン濃度が設定可能である。われわれの研究の当面の目標はラドンの体内挙動とその効果の調査であるため、主要な機能であるラドンの制御とトロンの除去について実験的に検討した。さらに、将来的な研究課題も見据えて、ケージ内のラドン子孫濃度と粒度分布についても実験的に検討した。

A radon test facility for small animals was developed in order to increase the statistical validity of differences of the biological response in various radon environments. This paper illustrates the performances of that facility, the first large-scale facility of its kind in Japan. The facility has a capability to conduct approximately 150 mouse-scale tests at the same time. The apparatus for exposing small animals to radon has six animal chamber groups with five independent cages each. Different radon concentrations in each animal chamber group are available. Because the first target of this study is to examine the in vivo behavior of radon and its effects, the major functions to control radon and to eliminate thoron were examined experimentally. Additionally, radon progeny concentrations and their particle size distributions in the cages were also examined experimentally to be considered in future projects.

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パーセンタイル:39.29

分野:Environmental Sciences

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