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A Comparative study on effect of continuous radon inhalation on several-time acute alcohol-induced oxidative damages of liver and brain in mouse

マウスの肝臓及び脳の急性アルコール性酸化障害に対する連続ラドン吸入の効果に関する比較研究

片岡 隆浩*; 迫田 晃弘*; 吉本 雅章*; 豊田 晃章*; 山本 祐紀*; 石森 有; 花元 克巳*; 川辺 睦*; 光延 文裕*; 山岡 聖典*

Kataoka, Takahiro*; Sakoda, Akihiro*; Yoshimoto, Masaaki*; Toyota, Teruaki*; Yamamoto, Yuki*; Ishimori, Yuu; Hanamoto, Katsumi*; Kawabe, Atsushi*; Mitsunobu, Fumihiro*; Yamaoka, Kiyonori*

マウスの肝臓と脳の急性アルコール性酸化障害に対する連続ラドン吸入の効果を検討した。抗酸化機能の分析より、アルコールを投与したマウスの肝臓と脳の過酸化脂質のレベルは、生理食塩水を投与したマウスより有意に高いことがわかった。しかし、アルコール投与マウスの肝臓中の過酸化脂質のレベルはラドン吸入によって有意に減少した。一方、生理食塩水投与マウスの脳中の過酸化脂質のレベルはラドン吸入によって有意に増大した。これらの結果は、ラドン吸入が抗酸化機能を亢進し、肝臓のアルコール性酸化障害を抑制すること、脳のラドン吸入効果は1週間だけ続くことを示唆している。

We examined the effect of continuous radon inhalation on acute alcohol-induced oxidative damage of mouse liver and brain. Assay of antioxidative functions indicated that lipid peroxide levels in both the liver and brain of the alcohol-treated mice were significantly higher than those of the saline-treated mice. However, the lipid peroxide level in the liver, but not in the brain, of alcohol-treated mice was significantly decreased by radon inhalation whereas that in the brain of saline-treated mice, but not in the liver of saline-treated mice, was significantly increased by radon inhalation. These findings suggest that radon inhalation inhibits alcohol-induced oxidative damage of liver due to activation of antioxidative functions and that radon inhalation exert only a week effect on the brains in comparing with the livers. They further suggest that alcohol administration protects against oxidative damage of the brain that is induced by radon inhalation.

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