Analysis of erythrocyte elements in chronic hepatitis C patients treated with interferon and ribavirin by in-air microPIXE

インターフェロンとリバビリンで治療されたC型慢性肝炎患者の赤血球要素の大気マイクロPIXE分析

長嶺 竹明*; 富岡 智*; 佐藤 隆博; 江夏 昌志; 神谷 富裕

Nagamine, Takeaki*; Tomioka, Satoru*; Sato, Takahiro; Koka, Masashi; Kamiya, Tomihiro

Chronic hepatitis C (CHC) patients treated with pegulated-interferon, ribavirin (Peg-IFN+RBV) and teraprevir (Peg-IFN+RBV+TPV) are frequently associated with anemia. This study is aimed at analyzing the elemental changes in erythrocytes to investigate the pathogenesis of anemia caused by combination of Peg-IFN and anti-viral drugs. Thirteen CHC patients (3 cases without IFN therapy, 7 cases treated with Peg-IFN+RBV, 3 cases treated with Peg-IFN+RBV+TPV) and 4 healthy controls were enrolled in this study. Whole blood was collected via peripheral vein, and prepared for PIXE analysis. Elemental distribution and elemental levels in erythrocytes were analyzed by in-air microPIXE at JAEA-Takasaki. The elemental distributions in erythrocytes were changed in CHC patients by receiving Peg-IFN+RBV. In addition, erythrocytes elements were altered by Peg-IFN+RBV+TPV, suggesting that the pathogenesis of anemia was different between Peg-IFN+RVB therapy and Peg-IFN+RBV+TPV therapy.