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Measurements of radon concentration in mouse blood following radon inhalation

ラドン吸入後のマウスの血液中ラドン濃度測定

石森 有; 田中 裕史; 迫田 晃弘; 片岡 隆浩*; 山岡 聖典*; 光延 文裕*

Ishimori, Yuu; Tanaka, Hiroshi; Sakoda, Akihiro; Kataoka, Takahiro*; Yamaoka, Kiyonori*; Mitsunobu, Fumihiro*

ラドン吸入によって様々な生体応答(例えば抗酸化機能の亢進など)が誘導されることは知られている。しかし、吸入ラドンの体内動態に関する実験データがあまりないため、この生体応答が吸収線量と関連付けられて議論されることはあまりない。本研究では、吸入ラドンの体内動態を検討するために、ラドン約1 MBq/$$^{3}$$を数分から1000分間で吸入させたマウスの血液中のラドン濃度を測定した。吸入後、マウスの心臓から直接採血し、液体シンチレーションカウンタで血中濃度を測定した。本測定では、原子力機構の水中ラドンの測定技術に基づいており、クエンチング補正も行っている。この結果、血液中ラドン濃度の飽和値は、1MBq/$$^{3}$$のラドン吸入当たり0.416$$pm$$0.014Bq/gであった。また、吸入時間の違いによる血中濃度の変化について、モデル計算で本実験結果をよく表現することもできた。

Various biological responses following radon inhalation are widely known. However, it is few that the responses are discussed quantitatively in relation to absorbed dose due to radon inhaled because experimental data of biokinetics of radon inhaled seem not to be many. To examine biokinetics of radon inhaled, radon concentration in mouse blood was measured after the inhalation of radon with about 1 MBq/$$^{3}$$ for several to 1000 minutes. Blood was collected from a mouse heart, and radon concentration in blood was determined by a liquid scintillation counter. This was based on the measurement technique used by JAEA for radon in water. The data were corrected taking into account quenching of scintillation. As the result, radon concentration in mouse blood was 0.416$$pm$$0.014 Bq/g in the condition saturated with 1 MBq/m$$^{3}$$ of radon concentration in the air. The time variation of radon concentration in mouse blood in the condition unsaturated was well expressed by our mathematical model.

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