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Measurements of radon activity concentration in mouse tissues and organs

マウスの組織・臓器におけるラドン濃度の測定

石森 有; 田中 裕史; 迫田 晃弘; 片岡 隆浩*; 山岡 聖典*; 光延 文裕*

Ishimori, Yuu; Tanaka, Hiroshi; Sakoda, Akihiro; Kataoka, Takahiro*; Yamaoka, Kiyonori*; Mitsunobu, Fumihiro*

吸入ラドンの体内動態を検討するため、約1MBq/m$$^{3}$$のラドンに曝露されたマウスの組織・臓器におけるラドン濃度を測定した。血液中のラドン濃度は液体シンチレーションカウンタで、組織・臓器は井戸型高純度半導体ゲルマニウム検出器で測定した。ラドン1MBq/m$$^{3}$$に曝露されたとき、血液中濃度の飽和値は0.410$$pm$$0.016Bq/gであった。分配係数は、肝臓で0.74$$pm$$0.19、筋肉で0.46$$pm$$0.13、脂肪組織で9.09$$pm$$0.49、その他臓器で0.22$$pm$$0.04であった。ラドンの体内動態モデルで上記結果を再現することにより、血液-空気間の分配係数は0.414と評価した。ラドン曝露中の血液中濃度の時間変動も評価した。また、本研究と先行研究の結果を詳細に比較検討した。

In order to investigate the biokinetics of inhaled radon, radon concentrations in mouse tissues and organs were determined after mice had been exposed to about 1 MBq/m$$^{3}$$ of radon in air. Radon concentrations in mouse blood and in other tissues and organs were measured with a liquid scintillation counter and with a well-type HP Ge detector, respectively. Radon concentration in mouse blood was 0.410$$pm$$0.016 Bq/g when saturated with 1 MBq/m$$^{3}$$ of radon concentration in air. In addition, average partition coefficients obtained were 0.74$$pm$$0.19 for liver, 0.46$$pm$$0.13 for muscle, 9.09$$pm$$0.49 for adipose tissue, and 0.22$$pm$$0.04 for other organs. With these results, a value of 0.414 for the blood-to-air partition coefficient was calculated by means of our physiologically based pharmacokinetic model. The time variation of radon concentration in mouse blood during exposure to radon was also calculated. All results are compared in detail with those found in the literature.

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パーセンタイル:100

分野:Biology

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