検索対象:     
報告書番号:
※ 半角英数字
 年 ~ 
 年

Potential inhibitory effects of low-dose thoron inhalation and ascorbic acid administration on alcohol-induced hepatopathy in mice

片岡 隆浩*; 石田 毅*; 直江 翔太*; 神崎 訓枝   ; 迫田 晃弘   ; 田中 裕史 ; 光延 文裕*; 山岡 聖典*

Kataoka, Takahiro*; Ishida, Tsuyoshi*; Naoe, Shota*; Kanzaki, Norie; Sakoda, Akihiro; Tanaka, Hiroshi; Mitsunobu, Fumihiro*; Yamaoka, Kiyonori*

Although thoron inhalation has antioxidative effects on several organs, there are no reports that thoron inhalation inhibits oxidative stress-induced damage. In the present study, we examined the combined effects of thoron inhalation and ascorbic acid (AA) administration on alcohol-induced liver damage. The mice were subjected to thoron inhalation at 500 or 2000 Bq/m$${^3}$$ and were administered 50% ethanol (alcohol) and 300 mg/kg AA. The results showed that although alcohol administration increased the levels of glutamic oxaloacetic transaminase (GOT) and glutamic pyruvic transaminase (GPT) in the serum, the combination of thoron inhalation (500 Bq/m$${^3}$$) and AA administration 24 h after alcohol administration effectively inhibited alcohol-induced liver damage. In conclusion, combination of thoron inhalation at 500 Bq/m$${^3}$$ and AA administration indicated an early recovery from alcohol-induced liver damage probably due to the increase of CAT activity.

Access

:

- Accesses

InCites™

:

パーセンタイル:32.67

分野:Biology

Altmetrics

:

[CLARIVATE ANALYTICS], [WEB OF SCIENCE], [HIGHLY CITED PAPER & CUP LOGO] and [HOT PAPER & FIRE LOGO] are trademarks of Clarivate Analytics, and/or its affiliated company or companies, and used herein by permission and/or license.