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Effectiveness of a combination of ML-EM and STIM-CT in PIXE-CT for biological specimens

生体試料のPIXE-CTにおけるML-EMとSTIM-CTの効果

佐藤 隆博; 江夏 昌志; 香西 直文   ; 清水 泰生*; 土橋 邦生*; 加田 渉; 横山 彰人; 大久保 猛; 山崎 明義; 石井 保行; 神谷 富裕

Sato, Takahiro; Koka, Masashi; Kozai, Naofumi; Shimizu, Yasuo*; Dobashi, Kunio*; Kada, Wataru; Yokoyama, Akihito; Okubo, Takeru; Yamazaki, Akiyoshi; Ishii, Yasuyuki; Kamiya, Tomihiro

PIXE-CTにおけるML-EMによる画像再構成においては、STIM-CTによって、入射粒子のエネルギー変化やX線の吸収を推定しなければならない。TIARAの3MeV, $$phi$$1$$mu$$mのプロトンマイクロビームを用い、試料を18$$^{circ}$$ずつ360$$^{circ}$$回転した場合に、その妥当性と期待される空間分解能を計算評価した。この計算においては、二次元の密度のSheppファントムを用いた。その結果、この方法がPIXE-CTの定量において、表面の強調を抑えるために有効であることがわかった。

In the ML-EM for PIXE-CT, energy loss of incident particles and absorption of X-rays affect must be estimated using STIM-CT. This paper shows the appropriateness and the expected spatial resolution of this method are evaluated by a computer simulation and some practical experiments using 3 MeV proton microbeam with a diameter of 1$$mu$$m at TIARA. The PIXE-CT experiments were carried out using a dried unicellulate and human lung tissue as a test sample placed on an automatic rotation stage, which made a full turn by rotating 360$$^{circ}$$ at each step of 18$$^{circ}$$ in vacuum. In the simulation, X-ray yield and absorption were calculated using density distribution of two-dimensional Shepp phantom. The results of those simulation and experiments have proved that this method is effective in PIXE-CT.

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