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ヒト肺癌由来細胞株における重粒子線誘発バイスタンダー効果による細胞死

Bystander killing of human lung cancer cells by heavy charged particle irradiation

原田 耕作*; 野中 哲生*; 浜田 信行*; 舟山 知夫; 桜井 英幸*; 坂下 哲哉; 和田 成一*; 河村 英将*; 長谷川 正俊*; 小林 泰彦; 中野 隆史*

Harada, Kosaku*; Nonaka, Tetsuo*; Hamada, Nobuyuki*; Funayama, Tomoo; Sakurai, Hideyuki*; Sakashita, Tetsuya; Wada, Seiichi*; Kawamura, Hidemasa*; Hasegawa, Masatoshi*; Kobayashi, Yasuhiko; Nakano, Takashi*

We have here examined clonogenic survival of confluent human lung cancer A549 cells exposed to X-rays or 220 MeV 12C$$^{5+}$$ charged particles. Targeted exposure of 0.001-0.005 % of cells within the confluent population were resulted in 8-15 % reduction of surviving fraction, suggesting that the induced bystander responses are involved in mechanism of cell death by heavy particles.

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