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Effects of ionizing radiation on locomotory behavior and mechanosensation in ${it Caenorhabditis elegans}$

${it Caenorhabditis elegans}$の運動と機械刺激知覚に対する放射線照射効果

鈴木 芳代; 坂下 哲哉; 簗瀬 澄乃*; 菊地 正博; 大庭 寛史; 東谷 篤志*; 浜田 信行*; 舟山 知夫; 深本 花菜; 辻 敏夫*; 小林 泰彦

Suzuki, Michiyo; Sakashita, Tetsuya; Yanase, Sumino*; Kikuchi, Masahiro; Oba, Hirofumi; Higashitani, Atsushi*; Hamada, Nobuyuki*; Funayama, Tomoo; Fukamoto, Kana; Tsuji, Toshio*; Kobayashi, Yasuhiko

We examined the effects of ionizing radiation (IR) on locomotory behavior and mechanosensation using a model organism, the nematode ${it Caenorhabditis elegans}$. Bacterial mechanosensation in ${it C. elegans}$ induces the dopamine-mediated slowing of locomotion in the presence of bacteria (food), known as the basal slowing response. We previously reported an IR-induced reduction of locomotory rate in the absence of food. In the present study, we observed a similar IR-induced reduction of locomotory rate in the ${it cat-2}$ mutant, which is defective in bacterial mechanosensation. The dose response pattern of the locomotory rate in the presence of food was relatively flat in wild-type animals, but not in ${it cat-2}$ mutants. This suggests that the dopamine system, which is related to bacterial mechanosensation in ${it C. elegans}$, might have a dominant effect on locomotory rate in the presence of food, which masks the effects of other stimuli. Moreover, we found that the behavioral responses of hydrogen peroxide-exposed wild-type animals are similar to those of IR-exposed animals. Our findings suggest that the IR-induced reduction of locomotory rate in the absence of food is mediated by a different pathway from that for bacterial mechanosensation, at least partially through IR-produced hydrogen peroxide.

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パーセンタイル:80.42

分野:Biology

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