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治療用重粒子線ブラッグピーク付近における水分解,1; ケイ光プローブを用いたOHラジカル収量測定

Water radiolysis near the Bragg peak of therapeutic heavy ions: 1. Measurement of OH yield with a fluorescent probe

山下 真一; 前山 拓哉*; 翠川 匡道*; Baldacchino, G.*; 田口 光正; 木村 敦; 工藤 久明*; 勝村 庸介; 村上 健*

Yamashita, Shinichi; Maeyama, Takuya*; Midorikawa, Masamichi*; Baldacchino, G.*; Taguchi, Mitsumasa; Kimura, Atsushi; Kudo, Hisaaki*; Katsumura, Yosuke; Murakami, Takeshi*

高エネルギー重粒子線を用いたガン治療は近年実用化され、高い治療実績をあげている。現象論的に効果的な治療が行えることがわかっているものの、その詳細なメカニズムはよくわかっておらず、生体主成分である水がどのように放射線分解するかを明らかにすることがまずは重要と言える。本研究では実際の治療でガン患部に重ね合わされるブラッグピーク周辺での水分解に着目し、間接効果において最も中心的な役割を担うと考えられているヒドロキシルラジカル($$^{.}$$OH)の収量測定を実施した。高エネルギー重粒子線では核破砕が起こるため、その寄与を$$^{.}$$OH収量から検討した。

Recently, cancer therapy with high-energy heavy ions has been utilized, showing high efficiency in actual treatment. While its effectiveness has already been certificated phenomenologically, detailed mechanism through which such a feature appears has not been clarified yet. Water is a main component of human body, and then, it is inevitably important to comprehend water radiolysis. In this study, water radiolysis near the Bragg peak was focused on because the peak is overlapped to cancer in actual treatment, and yield of hydroxyl radical ($$^{.}$$OH) has been determined because $$^{.}$$OH is assumed as a species most responsible to indirect action. In addition, contribution of fragmentation reactions which is significant for high-energy heavy ions were discussed from the viewpoint of $$^{.}$$OH yield.

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