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Dosimetric impact of a new computational voxel phantom series for the Japanese atomic bomb survivors; Methodological improvements and organ dose response functions

佐藤 達彦; 船本 幸代*; Paulbeck, C.*; Griffin, K.*; Lee, C.*; Cullings, H.*; Egbert, S. D.*; 遠藤 章; Hertel, N.*; Bolch, W. E.*

Radiation Research, 194(4), p.390 - 402, 2020/10

 被引用回数:0 パーセンタイル:100(Biology)



Concentration ratios of $$^{238}$$U and $$^{226}$$Ra for insects and amphibians living in the vicinity of the closed uranium mine at Ningyo-toge, Japan

迫田 晃弘; 村上 翔一*; 石森 有; 寳來 佐和子*

Journal of Radiation Research (Internet), 61(2), p.207 - 213, 2020/03

 被引用回数:0 パーセンタイル:100(Biology)

There is still a scarcity of data on the transfer of naturally occurring radionuclides to wildlife in various ecosystems. In the present study, concentration ratios (CR$$_{rm wo-media}$$) of $$^{238}$$U and $$^{226}$$Ra were obtained for grasshoppers, frogs and newts in terrestrial and freshwater ecosystems. Soil, water and animal samples were collected for two years in the vicinity of the closed uranium mine at Ningyo-toge, Japan. Three sites with different $$^{238}$$U and $$^{226}$$Ra levels were of interest: (a) Pond and its shore (PO); (b) Low level stream and its shore near overburden dump (OD); (c) Uranium mill tailings pond and its shore (MP). The activity concentrations in both soil and water were PO $${approx}$$ OD $$<$$ MP for $$^{238}$$U, and PO $$<$$ OD $$<$$ MP for $$^{226}$$Ra. Regarding the wildlife, $$^{238}$$U was able to be determined for all samples, but the detection of $$^{226}$$Ra was observed only for a part of samples (not detected for grasshoppers at all). The means and standard deviations of CR$$_{rm wo-soil}$$ or CR$$_{rm wo-water}$$ were then calculated and may indicate the insignificant dependence of CR$$_{rm wo-media}$$ on environmental conditions characterized by the tested sites. The present data on CR$$_{rm wo-media}$$ were compared to the corresponding data or surrogate data from the IAEA's database, showing both agreement and discrepancy. Our data would contribute to enhancing the available data for those radionuclides and animals. In particular, the transfer to amphibians, which are one of main links in common food webs, is reported here for the first time.


Temporal change in radiological environments on land after the Fukushima Daiichi Nuclear Power Plant accident

斎藤 公明; 三上 智; 安藤 真樹; 松田 規宏; 木名瀬 栄; 津田 修一; 佐藤 哲朗*; 関 暁之; 眞田 幸尚; Wainwright-Murakami, Haruko*; et al.

Journal of Radiation Protection and Research, 44(4), p.128 - 148, 2019/12

Massive environmental monitoring has been conducted continuously after the Fukushima accident with different monitoring methods having different features together with migration studies of radiocesium in diverse environments. At three months after the accident, multiple radionuclides were detected at many places; while it was confirmed that radiocesium was most important from the viewpoint of long-term exposures. The air dose rates in environments related to human living have decreased faster than expected from radioactive decay by a factor of 2-3 on average. An empirical model for predicting air dose rate distribution was developed based on statistical analysis of massive car-borne survey data. Some trials were performed to integrate different types of contamination maps to obtain an integrated map of better quantity. Annual external exposure doses for residents who would return to their home were estimated to less than a few mSv as a whole. The environmental data and knowledge have been provided for diverse-spectrum of people in different ways.


Dosimetric impact of a new computational voxel phantom series for the Japanese atomic bomb survivors; Pregnant females

Paulbeck, C.*; Griffin, K.*; Lee, C.*; Cullings, H.*; Egbert, S. D.*; 船本 幸代*; 佐藤 達彦; 遠藤 章; Hertel, N.*; Bolch, W. E.*

Radiation Research, 192(5), p.538 - 561, 2019/08

 被引用回数:2 パーセンタイル:57.17(Biology)

妊婦及び胎児の原爆生存者に対する被ばく線量評価は、放射線影響の疫学研究の上で極めて重要となる。従来は、女性の子宮壁に対する線量を妊婦及び胎児の被ばく線量と仮定していたが、本研究では、最新の計算科学記述を用いて受胎8, 15, 25, 38週齢の胎児及び妊婦に対する詳細人体モデルを構築し、その被ばく線量を精度よく計算した。その結果、従来手法では、光子及び中性子前方照射に対して最大で12-16%及び44-54%被ばく線量を過大評価していたことが分かった。これらの結果は、今後、妊婦及び胎児に対する放射線感受性の疫学調査を実施する上で、極めて重要となる。


Analysis of the high-dose-range radioresistance of prostate cancer cells, including cancer stem cells, based on a stochastic model

嵯峨 涼*; 松谷 悠佑; 高橋 玲*; 長谷川 和輝*; 伊達 広行*; 細川 洋一郎*

Journal of Radiation Research, 60(3), p.298 - 307, 2019/05

 被引用回数:9 パーセンタイル:12.78(Biology)



Dosimetric impact of a new computational voxel phantom series for the Japanese atomic bomb survivors; Children and adults

Griffin, K.*; Paulbeck, C.*; Bolch, W.*; Cullings, H.*; Egbert, S. D.*; 船本 幸代*; 佐藤 達彦; 遠藤 章; Hertel, N.*; Lee, C.*

Radiation Research, 191(4), p.369 - 379, 2019/04

 被引用回数:5 パーセンタイル:25.7(Biology)



A New Standard DNA Damage (SDD) data format

Schuemann, J.*; McNamara, A. L.*; Warmenhoven, J. W.*; Henthorn, N. T.*; Kirkby, K.*; Merchant, M. J.*; Ingram, S.*; Paganetti, H.*; Held, K. D.*; Ramos-Mendez, J.*; et al.

Radiation Research, 191(1), p.76 - 93, 2019/01

 被引用回数:27 パーセンタイル:0.98(Biology)



Validation of the physical and RBE-weighted dose estimator based on PHITS coupled with a microdosimetric kinetic model for proton therapy

高田 健太*; 佐藤 達彦; 熊田 博明*; 纐纈 純一*; 武居 秀行*; 櫻井 英幸*; 榮 武二*

Journal of Radiation Research, 59(1), p.91 - 99, 2018/01

 被引用回数:21 パーセンタイル:8.54(Biology)



Protective effects of hot spring water drinking and radon inhalation on ethanol-induced gastric mucosal injury in mice

恵谷 玲央*; 片岡 隆浩*; 神崎 訓枝*; 迫田 晃弘; 田中 裕史; 石森 有; 光延 文裕*; 田口 勇仁*; 山岡 聖典*

Journal of Radiation Research, 58(5), p.614 - 625, 2017/05

 被引用回数:7 パーセンタイル:43.47(Biology)



Measurement of neutron production double-differential cross-sections on carbon bombarded with 430 MeV/nucleon carbon ions

板敷 祐太朗*; 今林 洋一*; 執行 信寛*; 魚住 祐介*; 佐藤 大樹; 梶本 剛*; 佐波 俊哉*; 古場 裕介*; 松藤 成弘*

Journal of Radiation Protection and Research, 41(4), p.344 - 349, 2016/12

重粒子線治療は、根治性の高さや患者への身体的負担の小さなガン治療法として成果を上げているが、患者には術後の2次発ガンのリスクが伴う。このリスク評価では、体内の放射線挙動や核反応の理解が不可欠となり、放射線輸送計算コードが有用なツールとなる。計算コードの重イオン核反応に対する検証は十分でないため、放射線生成過程の実験データが必要となる。そこで、本研究では、新しいガン治療用のビームとして使用されている核子あたり430MeVの炭素ビームと人体構成物質との核反応から放出される中性子の二重微分断面積の実験データを整備した。実験は、放射線医学総合研究所のHIMAC加速器において実施した。核子当たり430MeVの炭素ビームを45$$^{circ}$$に傾けた5cm$${times}$$5cm$${times}$$1cmの固体炭素標的に入射し、生成される中性子を15$$^{circ}$$, 30$$^{circ}$$, 45$$^{circ}$$, 60$$^{circ}$$, 75$$^{circ}$$および90$$^{circ}$$方向に設置した中性子検出器で測定した。また、中性子の運動エネルギーは飛行時間法により決定した。取得した実験データとPHITSの計算値を比較したところ、PHITSはこのエネルギー領域における炭素からの中性子生成を適切に模擬できることが分かった。


Development of the graphite-moderated neutron calibration fields using $$^{241}$$Am-Be sources in JAEA-FRS

西野 翔; 谷村 嘉彦; 江幡 芳昭*; 吉澤 道夫

Journal of Radiation Protection and Research, 41(3), p.211 - 215, 2016/09



Evaluation of the intake of radon through skin from thermal water

迫田 晃弘; 石森 有; Tschiersch, J.*

Journal of Radiation Research, 57(4), p.336 - 342, 2016/07

 被引用回数:5 パーセンタイル:60.76(Biology)



Characteristics of radiation-resistant real-time neutron monitor for accelerator-based BNCT

中村 剛実; 坂佐井 馨; 中島 宏; 高宮 幸一*; 熊田 博明*

Journal of Radiation Protection and Research, 41(2), p.105 - 109, 2016/06



Difference in the action mechanism of radon inhalation and radon hot spring water drinking in suppression of hyperuricemia in mice

恵谷 玲央*; 片岡 隆浩*; 神崎 訓枝*; 迫田 晃弘; 田中 裕史; 石森 有; 光延 文裕*; 山岡 聖典*

Journal of Radiation Research, 57(3), p.250 - 257, 2016/06

 被引用回数:7 パーセンタイル:54.69(Biology)



Low-dose radiation risk and individual variation in radiation sensitivity in Fukushima

福永 久典*; 横谷 明徳

Journal of Radiation Research, 57(1), p.98 - 100, 2016/01

 被引用回数:7 パーセンタイル:10.46(Biology)

After the Fukushima Nuclear Power Plant accident in 2011 March, radiation doses have been measured for the residents by personal dosimeters and whole-body counters. In the current dose range, the potential radiation-induced risk could be small at the population level, however, should not be ignored. As suggested by NASA's reports on astronauts, the radiation sensitivity substantially varies depending on the individual genetic background. From the viewpoint of precision medicine, we note a possible issue: there might be the residents, including young children, with greater than average sensitivity because of their genetic background. Patients with DNA-damage-response defective disorders and the heterozygous carriers can be associated with the sensitivity as well as with cancer predisposition. We hereby propose that additional medical checkups for cancer, such as ultrasonography, gastrointestinal endoscopy, measurements of tumor markers in blood and urine, and genetic testing, should be combined in a balanced fashion to minimize their potential cancer risk in the future.


Secondary structure alterations of histones H2A and H2B in X-irradiated human cancer cells; Altered histones persist in cells for at least 24 hours

泉 雄大; 山本 悟史*; 藤井 健太郎; 横谷 明徳

Radiation Research, 184(5), p.554 - 558, 2015/11

 被引用回数:6 パーセンタイル:60.8(Biology)

We measured and compared the circular dichroism (CD) spectra and secondary structures of histone proteins H2A, H2B, and their variants extracted from X-irradiated and unirradiated human HeLa cells. Compared to unirradiated cells, a relative increase in $$alpha$$-helix structure and decrease in other secondary structures was observed in X-irradiated cells. These structural alterations persisted for at least 24 hours, which is substantially longer than the 2 hours generally known to be required for DNA double strand break repair.


On the dynamical approach of quantitative radiation biology

大内 則幸

Evolution of Ionizing Radiation Research, p.41 - 62, 2015/09



A Laser-plasma-produced soft X-ray laser at 89 eV generates DNA double-strand breaks in human cancer cells

佐藤 克俊*; 錦野 将元; 河内 哲哉; 下川 卓志*; 今井 高志*; 手島 昭樹*; 西村 博明*; 神門 正城

Journal of Radiation Research, 56(4), p.633 - 638, 2015/07

 被引用回数:1 パーセンタイル:90.78(Biology)



Spectrum of radiation-induced clustered non-DSB damage; A Monte Carlo track structure modelling and calculations

渡辺 立子; Rahmanian, S.*; Nikjoo, H.*

Radiation Research, 183(5), p.525 - 540, 2015/05

 被引用回数:41 パーセンタイル:6.69(Biology)

電子線やイオン照射によりDNAに生成する塩基損傷のスペクトルの算出を目的として、モンテカルロトラック構造計算法を用いて、細胞模擬環境中で生じるDNA損傷シミュレーションを行った。鎖切断と塩基損傷からなるDNA損傷ペクトルを、100eV-100keVの電子線と軟X線、数種類のイオン(3.2MeV/u proton、0.74と2.4MeV/u $$^{4}$$He、29MeV/u $$^{14}$$N、950MeV/u $$^{56}$$Fe)照射の場合について計算した。計算により見積もられた塩基損傷の生成量は、LETによらずに、一本鎖切断と比べて2-4倍多くなった。また、損傷の空間分布の解析を行った結果、塩基損傷が、鎖切断から成る損傷サイトの複雑化に大きく寄与していることが明らかになった。これらのスペクトルデータは、塩基除去修復によるDNA損傷修復過程のモデル化と損傷修復効率の研究にとって有益なものである。


Estimation of relative biological effectiveness for boron neutron capture therapy using the PHITS code coupled with a microdosimetric kinetic model

堀口 洋徳*; 佐藤 達彦; 熊田 博明*; 山本 哲哉*; 榮 武二*

Journal of Radiation Research, 56(2), p.382 - 390, 2015/03

 被引用回数:10 パーセンタイル:44.45(Biology)


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